8UW2
Structure of AKT1(E17K) with compound 3 (zinc-free)
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 34 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGTFGKVIlVkekatgryyamkilkkevIVAK |
Chain | Residue | Details |
A | LEU156-LYS189 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKleNLML |
Chain | Residue | Details |
A | VAL270-LEU282 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
A | MET281 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941 |
Chain | Residue | Details |
A | LYS14 | |
A | ARG23 | |
A | ASN53 | |
A | ARG86 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LYS163 | |
A | ILE186 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21775285 |
Chain | Residue | Details |
A | LYS14 | |
A | LYS20 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | HIS124 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | ASP126 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | VAL136 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by TNK2 => ECO:0000269|PubMed:20333297 |
Chain | Residue | Details |
A | LYS183 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by IKKE, PDPK1 and TBK1 => ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:18456494, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20481595, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:8978681, ECO:0000269|PubMed:9512493 |
Chain | Residue | Details |
A | TYR315 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:22629392 |
Chain | Residue | Details |
A | ASP126 | |
A | VAL136 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:22629392 |
Chain | Residue | Details |
A | THR312 | |
A | GLU319 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:22410793 |
Chain | Residue | Details |
A | THR291 |