8UV4

M. tuberculosis CTP synthase filament bound to substrates

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003883	molecular_function	CTP synthase activity
A	0004359	molecular_function	glutaminase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0097268	cellular_component	cytoophidium
B	0000166	molecular_function	nucleotide binding
B	0003883	molecular_function	CTP synthase activity
B	0004359	molecular_function	glutaminase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0097268	cellular_component	cytoophidium
E	0000166	molecular_function	nucleotide binding
E	0003883	molecular_function	CTP synthase activity
E	0004359	molecular_function	glutaminase activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0016874	molecular_function	ligase activity
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0097268	cellular_component	cytoophidium
F	0000166	molecular_function	nucleotide binding
F	0003883	molecular_function	CTP synthase activity
F	0004359	molecular_function	glutaminase activity
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0097268	cellular_component	cytoophidium
G	0000166	molecular_function	nucleotide binding
G	0003883	molecular_function	CTP synthase activity
G	0004359	molecular_function	glutaminase activity
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0016874	molecular_function	ligase activity
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0044210	biological_process	'de novo' CTP biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0097268	cellular_component	cytoophidium
H	0000166	molecular_function	nucleotide binding
H	0003883	molecular_function	CTP synthase activity
H	0004359	molecular_function	glutaminase activity
H	0005524	molecular_function	ATP binding
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0044210	biological_process	'de novo' CTP biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0097268	cellular_component	cytoophidium
K	0000166	molecular_function	nucleotide binding
K	0003883	molecular_function	CTP synthase activity
K	0004359	molecular_function	glutaminase activity
K	0005524	molecular_function	ATP binding
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006221	biological_process	pyrimidine nucleotide biosynthetic process
K	0006241	biological_process	CTP biosynthetic process
K	0016874	molecular_function	ligase activity
K	0019856	biological_process	pyrimidine nucleobase biosynthetic process
K	0042802	molecular_function	identical protein binding
K	0044210	biological_process	'de novo' CTP biosynthetic process
K	0046872	molecular_function	metal ion binding
K	0097268	cellular_component	cytoophidium
L	0000166	molecular_function	nucleotide binding
L	0003883	molecular_function	CTP synthase activity
L	0004359	molecular_function	glutaminase activity
L	0005524	molecular_function	ATP binding
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006221	biological_process	pyrimidine nucleotide biosynthetic process
L	0006241	biological_process	CTP biosynthetic process
L	0016874	molecular_function	ligase activity
L	0019856	biological_process	pyrimidine nucleobase biosynthetic process
L	0042802	molecular_function	identical protein binding
L	0044210	biological_process	'de novo' CTP biosynthetic process
L	0046872	molecular_function	metal ion binding
L	0097268	cellular_component	cytoophidium
R	0000166	molecular_function	nucleotide binding
R	0003883	molecular_function	CTP synthase activity
R	0004359	molecular_function	glutaminase activity
R	0005524	molecular_function	ATP binding
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0006221	biological_process	pyrimidine nucleotide biosynthetic process
R	0006241	biological_process	CTP biosynthetic process
R	0016874	molecular_function	ligase activity
R	0019856	biological_process	pyrimidine nucleobase biosynthetic process
R	0042802	molecular_function	identical protein binding
R	0044210	biological_process	'de novo' CTP biosynthetic process
R	0046872	molecular_function	metal ion binding
R	0097268	cellular_component	cytoophidium
V	0000166	molecular_function	nucleotide binding
V	0003883	molecular_function	CTP synthase activity
V	0004359	molecular_function	glutaminase activity
V	0005524	molecular_function	ATP binding
V	0005829	cellular_component	cytosol
V	0005886	cellular_component	plasma membrane
V	0006221	biological_process	pyrimidine nucleotide biosynthetic process
V	0006241	biological_process	CTP biosynthetic process
V	0016874	molecular_function	ligase activity
V	0019856	biological_process	pyrimidine nucleobase biosynthetic process
V	0042802	molecular_function	identical protein binding
V	0044210	biological_process	'de novo' CTP biosynthetic process
V	0046872	molecular_function	metal ion binding
V	0097268	cellular_component	cytoophidium
X	0000166	molecular_function	nucleotide binding
X	0003883	molecular_function	CTP synthase activity
X	0004359	molecular_function	glutaminase activity
X	0005524	molecular_function	ATP binding
X	0005829	cellular_component	cytosol
X	0005886	cellular_component	plasma membrane
X	0006221	biological_process	pyrimidine nucleotide biosynthetic process
X	0006241	biological_process	CTP biosynthetic process
X	0016874	molecular_function	ligase activity
X	0019856	biological_process	pyrimidine nucleobase biosynthetic process
X	0042802	molecular_function	identical protein binding
X	0044210	biological_process	'de novo' CTP biosynthetic process
X	0046872	molecular_function	metal ion binding
X	0097268	cellular_component	cytoophidium
b	0000166	molecular_function	nucleotide binding
b	0003883	molecular_function	CTP synthase activity
b	0004359	molecular_function	glutaminase activity
b	0005524	molecular_function	ATP binding
b	0005829	cellular_component	cytosol
b	0005886	cellular_component	plasma membrane
b	0006221	biological_process	pyrimidine nucleotide biosynthetic process
b	0006241	biological_process	CTP biosynthetic process
b	0016874	molecular_function	ligase activity
b	0019856	biological_process	pyrimidine nucleobase biosynthetic process
b	0042802	molecular_function	identical protein binding
b	0044210	biological_process	'de novo' CTP biosynthetic process
b	0046872	molecular_function	metal ion binding
b	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	3324
Details	Region: {"description":"Amidoligase domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Active site: {"description":"Nucleophile; for glutamine hydrolysis","evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26097035","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26097035","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26097035","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	168
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A7E5","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"26097035","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---