8UTY
KIF1A[1-393] P364L mutant AMP-PNP bound two-heads-bound state in complex with a microtubule
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007010 | biological_process | cytoskeleton organization |
| B | 0007017 | biological_process | microtubule-based process |
| E | 0000226 | biological_process | microtubule cytoskeleton organization |
| E | 0000278 | biological_process | mitotic cell cycle |
| E | 0003924 | molecular_function | GTPase activity |
| E | 0005200 | molecular_function | structural constituent of cytoskeleton |
| E | 0005525 | molecular_function | GTP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0005874 | cellular_component | microtubule |
| E | 0007017 | biological_process | microtubule-based process |
| E | 0015630 | cellular_component | microtubule cytoskeleton |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0046872 | molecular_function | metal ion binding |
| I | 0003924 | molecular_function | GTPase activity |
| I | 0005200 | molecular_function | structural constituent of cytoskeleton |
| I | 0005525 | molecular_function | GTP binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005856 | cellular_component | cytoskeleton |
| I | 0005874 | cellular_component | microtubule |
| I | 0007010 | biological_process | cytoskeleton organization |
| I | 0007017 | biological_process | microtubule-based process |
| K | 0003700 | molecular_function | DNA-binding transcription factor activity |
| K | 0003777 | molecular_function | microtubule motor activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0006355 | biological_process | regulation of DNA-templated transcription |
| K | 0007018 | biological_process | microtubule-based movement |
| K | 0008017 | molecular_function | microtubule binding |
| N | 0003700 | molecular_function | DNA-binding transcription factor activity |
| N | 0003777 | molecular_function | microtubule motor activity |
| N | 0005524 | molecular_function | ATP binding |
| N | 0006355 | biological_process | regulation of DNA-templated transcription |
| N | 0007018 | biological_process | microtubule-based movement |
| N | 0008017 | molecular_function | microtubule binding |
| S | 0000226 | biological_process | microtubule cytoskeleton organization |
| S | 0000278 | biological_process | mitotic cell cycle |
| S | 0003924 | molecular_function | GTPase activity |
| S | 0005200 | molecular_function | structural constituent of cytoskeleton |
| S | 0005525 | molecular_function | GTP binding |
| S | 0005737 | cellular_component | cytoplasm |
| S | 0005856 | cellular_component | cytoskeleton |
| S | 0005874 | cellular_component | microtubule |
| S | 0007017 | biological_process | microtubule-based process |
| S | 0015630 | cellular_component | microtubule cytoskeleton |
| S | 0016787 | molecular_function | hydrolase activity |
| S | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00227 |
| Number of Residues | 7 |
| Details | TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG |
| Chain | Residue | Details |
| B | GLY140-GLY146 | |
| A | GLY142-GLY148 |
| site_id | PS00228 |
| Number of Residues | 4 |
| Details | TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI |
| Chain | Residue | Details |
| B | MET1-ILE4 |
| site_id | PS00411 |
| Number of Residues | 12 |
| Details | KINESIN_MOTOR_1 Kinesin motor domain signature. SKIsLVDLAGSE |
| Chain | Residue | Details |
| K | SER242-GLU253 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 |
| Chain | Residue | Details |
| K | GLY97 | |
| N | GLY97 | |
| S | GLU254 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | GLN11 | |
| E | GLU71 | |
| E | SER140 | |
| E | GLY144 | |
| E | THR145 | |
| E | THR179 | |
| E | ASN206 | |
| E | ASN228 | |
| S | GLN11 | |
| S | GLU71 | |
| S | SER140 | |
| A | GLU71 | |
| S | GLY144 | |
| S | THR145 | |
| S | THR179 | |
| S | ASN206 | |
| S | ASN228 | |
| A | SER140 | |
| A | GLY144 | |
| A | THR145 | |
| A | THR179 | |
| A | ASN206 | |
| A | ASN228 | |
| E | GLN11 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | SITE: Involved in polymerization => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR451 | |
| E | TYR451 | |
| S | TYR451 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | LYS40 | |
| E | LYS40 | |
| S | LYS40 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | SER48 | |
| A | SER232 | |
| E | SER48 | |
| E | SER232 | |
| S | SER48 | |
| S | SER232 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| A | TYR282 | |
| E | TYR282 | |
| S | TYR282 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | ARG339 | |
| E | ARG339 | |
| S | ARG339 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| A | SER439 | |
| E | SER439 | |
| S | SER439 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | GLU443 | |
| E | GLU443 | |
| S | GLU443 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68369 |
| Chain | Residue | Details |
| A | GLU445 | |
| E | GLU445 | |
| S | GLU445 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q71U36 |
| Chain | Residue | Details |
| A | TYR451 | |
| E | TYR451 | |
| S | TYR451 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 9 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | LYS326 | |
| A | LYS370 | |
| E | LYS326 | |
| E | LYS370 | |
| S | LYS326 | |
| S | LYS370 |
