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8UQN

PLCb3-Gaq complex on membranes

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001664molecular_functionG protein-coupled receptor binding
A0001750cellular_componentphotoreceptor outer segment
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005794cellular_componentGolgi apparatus
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007206biological_processphospholipase C-activating G protein-coupled glutamate receptor signaling pathway
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007218biological_processneuropeptide signaling pathway
A0007596biological_processblood coagulation
A0007603biological_processphototransduction, visible light
A0009649biological_processentrainment of circadian clock
A0009755biological_processhormone-mediated signaling pathway
A0010543biological_processregulation of platelet activation
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0030234molecular_functionenzyme regulator activity
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031965cellular_componentnuclear membrane
A0034695biological_processresponse to prostaglandin E
A0046872molecular_functionmetal ion binding
A0050821biological_processprotein stabilization
A0060828biological_processregulation of canonical Wnt signaling pathway
A0070062cellular_componentextracellular exosome
A0071468biological_processcellular response to acidic pH
A0099524cellular_componentpostsynaptic cytosol
A0140582biological_processadenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
B0003073biological_processregulation of systemic arterial blood pressure
B0004435molecular_functionphosphatidylinositol-4,5-bisphosphate phospholipase C activity
B0004629molecular_functionphospholipase C activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
B0008081molecular_functionphosphoric diester hydrolase activity
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0016787molecular_functionhydrolase activity
B0032991cellular_componentprotein-containing complex
B0035556biological_processintracellular signal transduction
B0045296molecular_functioncadherin binding
B0046488biological_processphosphatidylinositol metabolic process
B0048015biological_processphosphatidylinositol-mediated signaling
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0060090molecular_functionmolecular adaptor activity
B0099524cellular_componentpostsynaptic cytosol
B0120548molecular_functionphosphatidylinositol phospholipase C activity
B0140582biological_processadenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
B0140677molecular_functionmolecular function activator activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00270
ChainResidueDetails
BHIS332
ATHR186
AASN274
ALYS275
AASP277
AALA331
BHIS379
ALYS52
ASER53
ATHR54
ASER156
ALEU180
AARG181
AARG183

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
BSER474
BSER1105

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER490
BSER495

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER537

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER926

237992

PDB entries from 2025-06-25

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