8UO8

Structure of synaptic vesicle protein 2B with padsevonil

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006836	biological_process	neurotransmitter transport
A	0007268	biological_process	chemical synaptic transmission
A	0008021	cellular_component	synaptic vesicle
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0030672	cellular_component	synaptic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0045202	cellular_component	synapse
A	0055085	biological_process	transmembrane transport
A	0099509	biological_process	regulation of presynaptic cytosolic calcium ion concentration
A	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	17
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. LGGLADKLGRKrvlsm.S

Chain	Residue	Details
A	LEU165-SER181

---

site_id	PS00217
Number of Residues	26
Details	SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. IsGIGiGGalpivfaYfsEflsrekR

Chain	Residue	Details
A	ILE207-ARG232

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	250
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-GLN108
A	ASP170-LEU182
A	LEU227-SER237
A	GLU299-THR390
A	ALA557-ARG565
A	THR614-ALA626
A	ARG673-MET683

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	TRP109-VAL129
A	ILE593-ILE613
A	PHE627-VAL649
A	VAL654-LEU672
A	MET149-ALA169
A	ALA183-PHE203
A	LEU206-PHE226
A	TRP238-ILE258
A	VAL278-PRO298
A	LEU391-PHE411
A	PHE536-SER556
A	LEU566-GLY586

---

site_id	SWS_FT_FI3
Number of Residues	168
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	SER130-GLY148
A	CYS204-ARG205
A	PRO259-ARG277
A	PRO412-ASP535
A	ASN587-MET592
A	GLY650-LYS653

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BG39

Chain	Residue	Details
A	SER33

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8BG39

Chain	Residue	Details
A	THR36

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BG39

Chain	Residue	Details
A	TYR423

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN441
A	ASN491
A	ASN516

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