8UFK
Human PU.1 ETS-Domain (165-270) Bound to d(AATAAAAGCGGAAGTG)
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 166 |
| Details | DNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237 |
| Chain | Residue | Details |
| E | ILE170-SER253 | |
| F | ILE170-SER253 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: forms a salt bridge with the phosphate backbone of the opposite strand downstream of the GGAA core sequence => ECO:0000250|UniProtKB:P17433 |
| Chain | Residue | Details |
| E | LYS217 | |
| F | LYS217 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: contacts bases in the GGAA sequence in the major groove => ECO:0000250|UniProtKB:P17433 |
| Chain | Residue | Details |
| E | ARG230 | |
| E | ARG233 | |
| F | ARG230 | |
| F | ARG233 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: contacts the phosphate backbone of the GGAA sequence in the minor groove upstream => ECO:0000250|UniProtKB:P17433 |
| Chain | Residue | Details |
| E | LYS243 | |
| F | LYS243 |
