8UET

In-situ complex I, Deactive class02

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1A	0005739	cellular_component	mitochondrion
1A	0005743	cellular_component	mitochondrial inner membrane
1A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1A	0016020	cellular_component	membrane
1A	0045271	cellular_component	respiratory chain complex I
1A	1902600	biological_process	proton transmembrane transport
1B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1B	0046872	molecular_function	metal ion binding
1B	0048038	molecular_function	quinone binding
1B	0051536	molecular_function	iron-sulfur cluster binding
1B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1B	1902600	biological_process	proton transmembrane transport
1C	0003954	molecular_function	NADH dehydrogenase activity
1C	0005739	cellular_component	mitochondrion
1C	0005743	cellular_component	mitochondrial inner membrane
1C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1C	0016020	cellular_component	membrane
1C	0016604	cellular_component	nuclear body
1C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1C	0031966	cellular_component	mitochondrial membrane
1C	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1C	0045271	cellular_component	respiratory chain complex I
1C	0072593	biological_process	reactive oxygen species metabolic process
1C	1902600	biological_process	proton transmembrane transport
1D	0005743	cellular_component	mitochondrial inner membrane
1D	0016491	molecular_function	oxidoreductase activity
1D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1D	0045271	cellular_component	respiratory chain complex I
1D	0048038	molecular_function	quinone binding
1D	0051287	molecular_function	NAD binding
1D	0051536	molecular_function	iron-sulfur cluster binding
1D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1E	0005739	cellular_component	mitochondrion
1E	0005743	cellular_component	mitochondrial inner membrane
1E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1E	0007399	biological_process	nervous system development
1E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1E	0016491	molecular_function	oxidoreductase activity
1E	0045271	cellular_component	respiratory chain complex I
1E	0046872	molecular_function	metal ion binding
1E	0048738	biological_process	cardiac muscle tissue development
1E	0051536	molecular_function	iron-sulfur cluster binding
1E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
1E	1902600	biological_process	proton transmembrane transport
1F	0005739	cellular_component	mitochondrion
1F	0005743	cellular_component	mitochondrial inner membrane
1F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1F	0010181	molecular_function	FMN binding
1F	0016020	cellular_component	membrane
1F	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
1F	0045271	cellular_component	respiratory chain complex I
1F	0046872	molecular_function	metal ion binding
1F	0051287	molecular_function	NAD binding
1F	0051536	molecular_function	iron-sulfur cluster binding
1F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1F	1902600	biological_process	proton transmembrane transport
1G	0005739	cellular_component	mitochondrion
1G	0005743	cellular_component	mitochondrial inner membrane
1G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1G	0016020	cellular_component	membrane
1G	0016491	molecular_function	oxidoreductase activity
1G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1G	0042773	biological_process	ATP synthesis coupled electron transport
1G	0045271	cellular_component	respiratory chain complex I
1G	0046872	molecular_function	metal ion binding
1G	0051536	molecular_function	iron-sulfur cluster binding
1G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
1G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1G	1902600	biological_process	proton transmembrane transport
1H	0003954	molecular_function	NADH dehydrogenase activity
1H	0005739	cellular_component	mitochondrion
1H	0005743	cellular_component	mitochondrial inner membrane
1H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1H	0009060	biological_process	aerobic respiration
1H	0016020	cellular_component	membrane
1H	0031966	cellular_component	mitochondrial membrane
1H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1H	0045271	cellular_component	respiratory chain complex I
1H	1902600	biological_process	proton transmembrane transport
1I	0003954	molecular_function	NADH dehydrogenase activity
1I	0005739	cellular_component	mitochondrion
1I	0005743	cellular_component	mitochondrial inner membrane
1I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1I	0016020	cellular_component	membrane
1I	0016491	molecular_function	oxidoreductase activity
1I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1I	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1I	0045271	cellular_component	respiratory chain complex I
1I	0046872	molecular_function	metal ion binding
1I	0051536	molecular_function	iron-sulfur cluster binding
1I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1I	1902600	biological_process	proton transmembrane transport
1J	0005739	cellular_component	mitochondrion
1J	0005743	cellular_component	mitochondrial inner membrane
1J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1J	0016020	cellular_component	membrane
1J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1J	0045271	cellular_component	respiratory chain complex I
1J	1902600	biological_process	proton transmembrane transport
1K	0005739	cellular_component	mitochondrion
1K	0005743	cellular_component	mitochondrial inner membrane
1K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1K	0016020	cellular_component	membrane
1K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1K	0042773	biological_process	ATP synthesis coupled electron transport
1K	0045271	cellular_component	respiratory chain complex I
1K	1902600	biological_process	proton transmembrane transport
1L	0005739	cellular_component	mitochondrion
1L	0005743	cellular_component	mitochondrial inner membrane
1L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1L	0015990	biological_process	electron transport coupled proton transport
1L	0016020	cellular_component	membrane
1L	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1L	0042773	biological_process	ATP synthesis coupled electron transport
1L	0045271	cellular_component	respiratory chain complex I
1M	0003954	molecular_function	NADH dehydrogenase activity
1M	0005739	cellular_component	mitochondrion
1M	0005743	cellular_component	mitochondrial inner membrane
1M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1M	0009060	biological_process	aerobic respiration
1M	0015990	biological_process	electron transport coupled proton transport
1M	0016020	cellular_component	membrane
1M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1M	0042773	biological_process	ATP synthesis coupled electron transport
1M	0045271	cellular_component	respiratory chain complex I
1M	0048039	molecular_function	ubiquinone binding
1N	0005739	cellular_component	mitochondrion
1N	0005743	cellular_component	mitochondrial inner membrane
1N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1N	0016020	cellular_component	membrane
1N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1N	0045271	cellular_component	respiratory chain complex I
1N	0072593	biological_process	reactive oxygen species metabolic process
1N	1902600	biological_process	proton transmembrane transport
1O	0005739	cellular_component	mitochondrion
1O	0005759	cellular_component	mitochondrial matrix
1O	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1P	0005739	cellular_component	mitochondrion
1P	0005759	cellular_component	mitochondrial matrix
1Q	0005739	cellular_component	mitochondrion
1Q	0005743	cellular_component	mitochondrial inner membrane
1Q	0007420	biological_process	brain development
1Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1Q	0016020	cellular_component	membrane
1Q	0022900	biological_process	electron transport chain
1Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1Q	0045271	cellular_component	respiratory chain complex I
1Q	0051591	biological_process	response to cAMP
1Q	0072593	biological_process	reactive oxygen species metabolic process
1Q	1902600	biological_process	proton transmembrane transport
1R	0001822	biological_process	kidney development
1R	0005739	cellular_component	mitochondrion
1R	0005743	cellular_component	mitochondrial inner membrane
1R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1R	0006631	biological_process	fatty acid metabolic process
1R	0006936	biological_process	muscle contraction
1R	0007005	biological_process	mitochondrion organization
1R	0010467	biological_process	gene expression
1R	0016020	cellular_component	membrane
1R	0017145	biological_process	stem cell division
1R	0022904	biological_process	respiratory electron transport chain
1R	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
1R	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1R	0035264	biological_process	multicellular organism growth
1R	0045271	cellular_component	respiratory chain complex I
1R	0051881	biological_process	regulation of mitochondrial membrane potential
1R	0061458	biological_process	reproductive system development
1R	0072359	biological_process	circulatory system development
1R	0072497	biological_process	mesenchymal stem cell differentiation
1R	0072593	biological_process	reactive oxygen species metabolic process
1R	0090398	biological_process	cellular senescence
1R	0097168	biological_process	mesenchymal stem cell proliferation
1S	0005739	cellular_component	mitochondrion
1S	0005743	cellular_component	mitochondrial inner membrane
1S	0016020	cellular_component	membrane
1S	0045271	cellular_component	respiratory chain complex I
1T	0005739	cellular_component	mitochondrion
1T	0006629	biological_process	lipid metabolic process
1T	0006631	biological_process	fatty acid metabolic process
1T	0006633	biological_process	fatty acid biosynthetic process
1T	0031966	cellular_component	mitochondrial membrane
1T	0045271	cellular_component	respiratory chain complex I
1U	0005739	cellular_component	mitochondrion
1U	0006629	biological_process	lipid metabolic process
1U	0006631	biological_process	fatty acid metabolic process
1U	0006633	biological_process	fatty acid biosynthetic process
1U	0031966	cellular_component	mitochondrial membrane
1U	0045271	cellular_component	respiratory chain complex I
1V	0005739	cellular_component	mitochondrion
1V	0005743	cellular_component	mitochondrial inner membrane
1V	0016020	cellular_component	membrane
1V	0022904	biological_process	respiratory electron transport chain
1W	0005739	cellular_component	mitochondrion
1W	0005743	cellular_component	mitochondrial inner membrane
1W	0016020	cellular_component	membrane
1W	0045271	cellular_component	respiratory chain complex I
1X	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1Y	0005739	cellular_component	mitochondrion
1Y	0005743	cellular_component	mitochondrial inner membrane
1Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1Y	0016020	cellular_component	membrane
1Y	0045271	cellular_component	respiratory chain complex I
1Z	0005739	cellular_component	mitochondrion
1Z	0005743	cellular_component	mitochondrial inner membrane
1Z	0016020	cellular_component	membrane
1Z	0045271	cellular_component	respiratory chain complex I
1b	0005739	cellular_component	mitochondrion
1b	0005743	cellular_component	mitochondrial inner membrane
1b	0016020	cellular_component	membrane
1b	0045271	cellular_component	respiratory chain complex I
1c	0005739	cellular_component	mitochondrion
1c	0045271	cellular_component	respiratory chain complex I
1d	0005737	cellular_component	cytoplasm
1d	0005739	cellular_component	mitochondrion
1d	0005743	cellular_component	mitochondrial inner membrane
1d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1d	0016020	cellular_component	membrane
1d	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1d	0045271	cellular_component	respiratory chain complex I
1e	0005739	cellular_component	mitochondrion
1e	0005743	cellular_component	mitochondrial inner membrane
1e	0005758	cellular_component	mitochondrial intermembrane space
1e	0016020	cellular_component	membrane
1e	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1e	0045271	cellular_component	respiratory chain complex I
1f	0005739	cellular_component	mitochondrion
1f	0005743	cellular_component	mitochondrial inner membrane
1f	0016020	cellular_component	membrane
1h	0005654	cellular_component	nucleoplasm
1h	0005739	cellular_component	mitochondrion
1h	0005743	cellular_component	mitochondrial inner membrane
1h	0016020	cellular_component	membrane
1h	0045271	cellular_component	respiratory chain complex I
1i	0005739	cellular_component	mitochondrion
1i	0005743	cellular_component	mitochondrial inner membrane
1i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1i	0016020	cellular_component	membrane
1j	0005739	cellular_component	mitochondrion
1j	0005743	cellular_component	mitochondrial inner membrane
1j	0016020	cellular_component	membrane
1j	0045271	cellular_component	respiratory chain complex I
1k	0005739	cellular_component	mitochondrion
1k	0005743	cellular_component	mitochondrial inner membrane
1k	0016020	cellular_component	membrane
1k	0022900	biological_process	electron transport chain
1l	0005739	cellular_component	mitochondrion
1l	0005743	cellular_component	mitochondrial inner membrane
1l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1l	0016020	cellular_component	membrane
1l	0045271	cellular_component	respiratory chain complex I
1m	0005654	cellular_component	nucleoplasm
1m	0005739	cellular_component	mitochondrion
1m	0005743	cellular_component	mitochondrial inner membrane
1m	0016020	cellular_component	membrane
1m	0045271	cellular_component	respiratory chain complex I
1n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1o	0005739	cellular_component	mitochondrion
1o	0005743	cellular_component	mitochondrial inner membrane
1o	0005758	cellular_component	mitochondrial intermembrane space
1o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1o	0016020	cellular_component	membrane
1o	0045271	cellular_component	respiratory chain complex I
1o	1902600	biological_process	proton transmembrane transport
1q	0005739	cellular_component	mitochondrion
1q	0005743	cellular_component	mitochondrial inner membrane
1q	0016020	cellular_component	membrane
1q	0045271	cellular_component	respiratory chain complex I
1r	0005739	cellular_component	mitochondrion
1r	0005743	cellular_component	mitochondrial inner membrane
1r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1r	0016020	cellular_component	membrane
1r	0042773	biological_process	ATP synthesis coupled electron transport
1r	0045271	cellular_component	respiratory chain complex I
1s	0005739	cellular_component	mitochondrion
1s	0005743	cellular_component	mitochondrial inner membrane
1s	0016020	cellular_component	membrane
1s	0045271	cellular_component	respiratory chain complex I

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
1T	ASP39-MET54

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
1T	ASP64-ILE76

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
1I	CYS77-PRO88
1I	CYS116-PRO127

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
1D	LEU83-LYS94

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
1C	GLU131-LEU152

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
1G	PRO38-CYS55

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
1G	CYS105-GLN117

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
1G	ARG152-PHE162

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
1F	GLY180-SER195

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
1F	GLU357-GLY368

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDALKLVtKE

Chain	Residue	Details
1H	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
1H	PRO197-GLY210

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
1E	ASP134-PRO152

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
1B	GLY135-PRO151

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	885
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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