8UBU

Cryo-EM structure of dimeric SCF-FBXL17-BACH1BTB E3 ligase complex close conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006879	biological_process	intracellular iron ion homeostasis
A	0007346	biological_process	regulation of mitotic cell cycle
A	0010564	biological_process	regulation of cell cycle process
A	0010824	biological_process	regulation of centrosome duplication
A	0014033	biological_process	neural crest cell differentiation
A	0016567	biological_process	protein ubiquitination
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0030510	biological_process	regulation of BMP signaling pathway
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031461	cellular_component	cullin-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032006	biological_process	regulation of TOR signaling
A	0034599	biological_process	cellular response to oxidative stress
A	0042752	biological_process	regulation of circadian rhythm
A	0042981	biological_process	regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0050727	biological_process	regulation of inflammatory response
A	0051298	biological_process	centrosome duplication
A	0051726	biological_process	regulation of cell cycle
A	0060173	biological_process	limb development
A	0060271	biological_process	cilium assembly
A	0070936	biological_process	protein K48-linked ubiquitination
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1901524	biological_process	regulation of mitophagy
A	1904415	biological_process	regulation of xenophagy
A	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
A	2000001	biological_process	regulation of DNA damage checkpoint
B	0008270	molecular_function	zinc ion binding
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000209	biological_process	protein polyubiquitination
C	0000785	cellular_component	chromatin
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006879	biological_process	intracellular iron ion homeostasis
C	0007346	biological_process	regulation of mitotic cell cycle
C	0008013	molecular_function	beta-catenin binding
C	0010564	biological_process	regulation of cell cycle process
C	0010824	biological_process	regulation of centrosome duplication
C	0014033	biological_process	neural crest cell differentiation
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0019904	molecular_function	protein domain specific binding
C	0030510	biological_process	regulation of BMP signaling pathway
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
C	0031507	biological_process	heterochromatin formation
C	0031519	cellular_component	PcG protein complex
C	0032006	biological_process	regulation of TOR signaling
C	0042752	biological_process	regulation of circadian rhythm
C	0042981	biological_process	regulation of apoptotic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0050727	biological_process	regulation of inflammatory response
C	0051124	biological_process	synaptic assembly at neuromuscular junction
C	0051298	biological_process	centrosome duplication
C	0051457	biological_process	maintenance of protein location in nucleus
C	0051726	biological_process	regulation of cell cycle
C	0060173	biological_process	limb development
C	0060271	biological_process	cilium assembly
C	0070936	biological_process	protein K48-linked ubiquitination
C	0097602	molecular_function	cullin family protein binding
C	0140677	molecular_function	molecular function activator activity
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1901524	biological_process	regulation of mitophagy
C	1904415	biological_process	regulation of xenophagy
C	1990444	molecular_function	F-box domain binding
C	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	1990757	molecular_function	ubiquitin ligase activator activity
C	2000001	biological_process	regulation of DNA damage checkpoint
G	0000082	biological_process	G1/S transition of mitotic cell cycle
G	0000209	biological_process	protein polyubiquitination
G	0000785	cellular_component	chromatin
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006338	biological_process	chromatin remodeling
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006879	biological_process	intracellular iron ion homeostasis
G	0007346	biological_process	regulation of mitotic cell cycle
G	0008013	molecular_function	beta-catenin binding
G	0010564	biological_process	regulation of cell cycle process
G	0010824	biological_process	regulation of centrosome duplication
G	0014033	biological_process	neural crest cell differentiation
G	0016567	biological_process	protein ubiquitination
G	0019005	cellular_component	SCF ubiquitin ligase complex
G	0019904	molecular_function	protein domain specific binding
G	0030510	biological_process	regulation of BMP signaling pathway
G	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
G	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
G	0031507	biological_process	heterochromatin formation
G	0031519	cellular_component	PcG protein complex
G	0032006	biological_process	regulation of TOR signaling
G	0042752	biological_process	regulation of circadian rhythm
G	0042981	biological_process	regulation of apoptotic process
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0050727	biological_process	regulation of inflammatory response
G	0051124	biological_process	synaptic assembly at neuromuscular junction
G	0051298	biological_process	centrosome duplication
G	0051457	biological_process	maintenance of protein location in nucleus
G	0051726	biological_process	regulation of cell cycle
G	0060173	biological_process	limb development
G	0060271	biological_process	cilium assembly
G	0070936	biological_process	protein K48-linked ubiquitination
G	0097602	molecular_function	cullin family protein binding
G	0140677	molecular_function	molecular function activator activity
G	0160072	molecular_function	ubiquitin ligase complex scaffold activity
G	1901524	biological_process	regulation of mitophagy
G	1904415	biological_process	regulation of xenophagy
G	1990444	molecular_function	F-box domain binding
G	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
G	1990757	molecular_function	ubiquitin ligase activator activity
G	2000001	biological_process	regulation of DNA damage checkpoint
H	0000082	biological_process	G1/S transition of mitotic cell cycle
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006879	biological_process	intracellular iron ion homeostasis
H	0007346	biological_process	regulation of mitotic cell cycle
H	0010564	biological_process	regulation of cell cycle process
H	0010824	biological_process	regulation of centrosome duplication
H	0014033	biological_process	neural crest cell differentiation
H	0016567	biological_process	protein ubiquitination
H	0019005	cellular_component	SCF ubiquitin ligase complex
H	0030510	biological_process	regulation of BMP signaling pathway
H	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032006	biological_process	regulation of TOR signaling
H	0034599	biological_process	cellular response to oxidative stress
H	0042752	biological_process	regulation of circadian rhythm
H	0042981	biological_process	regulation of apoptotic process
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0050727	biological_process	regulation of inflammatory response
H	0051298	biological_process	centrosome duplication
H	0051726	biological_process	regulation of cell cycle
H	0060173	biological_process	limb development
H	0060271	biological_process	cilium assembly
H	0070936	biological_process	protein K48-linked ubiquitination
H	0097193	biological_process	intrinsic apoptotic signaling pathway
H	0160072	molecular_function	ubiquitin ligase complex scaffold activity
H	1901524	biological_process	regulation of mitophagy
H	1904415	biological_process	regulation of xenophagy
H	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
H	2000001	biological_process	regulation of DNA damage checkpoint
I	0008270	molecular_function	zinc ion binding

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA

Chain	Residue	Details
A	ILE749-ALA776

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	132
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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