8U7J

Crystal Structure of Staphylococcus aureus PLP synthase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006520	biological_process	amino acid metabolic process
A	0008615	biological_process	pyridoxine biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016843	molecular_function	amine-lyase activity
A	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
A	0042819	biological_process	vitamin B6 biosynthetic process
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0008615	biological_process	pyridoxine biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016843	molecular_function	amine-lyase activity
B	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
B	0042819	biological_process	vitamin B6 biosynthetic process
B	0042823	biological_process	pyridoxal phosphate biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0008615	biological_process	pyridoxine biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016843	molecular_function	amine-lyase activity
C	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
C	0042819	biological_process	vitamin B6 biosynthetic process
C	0042823	biological_process	pyridoxal phosphate biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0008615	biological_process	pyridoxine biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016843	molecular_function	amine-lyase activity
D	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
D	0042819	biological_process	vitamin B6 biosynthetic process
D	0042823	biological_process	pyridoxal phosphate biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0008615	biological_process	pyridoxine biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016843	molecular_function	amine-lyase activity
E	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
E	0042819	biological_process	vitamin B6 biosynthetic process
E	0042823	biological_process	pyridoxal phosphate biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0008615	biological_process	pyridoxine biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016843	molecular_function	amine-lyase activity
F	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
F	0042819	biological_process	vitamin B6 biosynthetic process
F	0042823	biological_process	pyridoxal phosphate biosynthetic process
G	0006520	biological_process	amino acid metabolic process
G	0008615	biological_process	pyridoxine biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016843	molecular_function	amine-lyase activity
G	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
G	0042819	biological_process	vitamin B6 biosynthetic process
G	0042823	biological_process	pyridoxal phosphate biosynthetic process
H	0006520	biological_process	amino acid metabolic process
H	0008615	biological_process	pyridoxine biosynthetic process
H	0016829	molecular_function	lyase activity
H	0016843	molecular_function	amine-lyase activity
H	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
H	0042819	biological_process	vitamin B6 biosynthetic process
H	0042823	biological_process	pyridoxal phosphate biosynthetic process
I	0006520	biological_process	amino acid metabolic process
I	0008615	biological_process	pyridoxine biosynthetic process
I	0016829	molecular_function	lyase activity
I	0016843	molecular_function	amine-lyase activity
I	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
I	0042819	biological_process	vitamin B6 biosynthetic process
I	0042823	biological_process	pyridoxal phosphate biosynthetic process
J	0006520	biological_process	amino acid metabolic process
J	0008615	biological_process	pyridoxine biosynthetic process
J	0016829	molecular_function	lyase activity
J	0016843	molecular_function	amine-lyase activity
J	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
J	0042819	biological_process	vitamin B6 biosynthetic process
J	0042823	biological_process	pyridoxal phosphate biosynthetic process
K	0006520	biological_process	amino acid metabolic process
K	0008615	biological_process	pyridoxine biosynthetic process
K	0016829	molecular_function	lyase activity
K	0016843	molecular_function	amine-lyase activity
K	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
K	0042819	biological_process	vitamin B6 biosynthetic process
K	0042823	biological_process	pyridoxal phosphate biosynthetic process
L	0006520	biological_process	amino acid metabolic process
L	0008615	biological_process	pyridoxine biosynthetic process
L	0016829	molecular_function	lyase activity
L	0016843	molecular_function	amine-lyase activity
L	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
L	0042819	biological_process	vitamin B6 biosynthetic process
L	0042823	biological_process	pyridoxal phosphate biosynthetic process
M	0004359	molecular_function	glutaminase activity
M	0005829	cellular_component	cytosol
M	0006543	biological_process	L-glutamine catabolic process
M	0008614	biological_process	pyridoxine metabolic process
M	0016787	molecular_function	hydrolase activity
M	0016829	molecular_function	lyase activity
M	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
M	0042819	biological_process	vitamin B6 biosynthetic process
M	0042823	biological_process	pyridoxal phosphate biosynthetic process
M	1903600	cellular_component	glutaminase complex
N	0004359	molecular_function	glutaminase activity
N	0005829	cellular_component	cytosol
N	0006543	biological_process	L-glutamine catabolic process
N	0008614	biological_process	pyridoxine metabolic process
N	0016787	molecular_function	hydrolase activity
N	0016829	molecular_function	lyase activity
N	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
N	0042819	biological_process	vitamin B6 biosynthetic process
N	0042823	biological_process	pyridoxal phosphate biosynthetic process
N	1903600	cellular_component	glutaminase complex
O	0004359	molecular_function	glutaminase activity
O	0005829	cellular_component	cytosol
O	0006543	biological_process	L-glutamine catabolic process
O	0008614	biological_process	pyridoxine metabolic process
O	0016787	molecular_function	hydrolase activity
O	0016829	molecular_function	lyase activity
O	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
O	0042819	biological_process	vitamin B6 biosynthetic process
O	0042823	biological_process	pyridoxal phosphate biosynthetic process
O	1903600	cellular_component	glutaminase complex
P	0004359	molecular_function	glutaminase activity
P	0005829	cellular_component	cytosol
P	0006543	biological_process	L-glutamine catabolic process
P	0008614	biological_process	pyridoxine metabolic process
P	0016787	molecular_function	hydrolase activity
P	0016829	molecular_function	lyase activity
P	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
P	0042819	biological_process	vitamin B6 biosynthetic process
P	0042823	biological_process	pyridoxal phosphate biosynthetic process
P	1903600	cellular_component	glutaminase complex
Q	0004359	molecular_function	glutaminase activity
Q	0005829	cellular_component	cytosol
Q	0006543	biological_process	L-glutamine catabolic process
Q	0008614	biological_process	pyridoxine metabolic process
Q	0016787	molecular_function	hydrolase activity
Q	0016829	molecular_function	lyase activity
Q	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Q	0042819	biological_process	vitamin B6 biosynthetic process
Q	0042823	biological_process	pyridoxal phosphate biosynthetic process
Q	1903600	cellular_component	glutaminase complex
R	0004359	molecular_function	glutaminase activity
R	0005829	cellular_component	cytosol
R	0006543	biological_process	L-glutamine catabolic process
R	0008614	biological_process	pyridoxine metabolic process
R	0016787	molecular_function	hydrolase activity
R	0016829	molecular_function	lyase activity
R	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
R	0042819	biological_process	vitamin B6 biosynthetic process
R	0042823	biological_process	pyridoxal phosphate biosynthetic process
R	1903600	cellular_component	glutaminase complex
S	0004359	molecular_function	glutaminase activity
S	0005829	cellular_component	cytosol
S	0006543	biological_process	L-glutamine catabolic process
S	0008614	biological_process	pyridoxine metabolic process
S	0016787	molecular_function	hydrolase activity
S	0016829	molecular_function	lyase activity
S	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
S	0042819	biological_process	vitamin B6 biosynthetic process
S	0042823	biological_process	pyridoxal phosphate biosynthetic process
S	1903600	cellular_component	glutaminase complex
T	0004359	molecular_function	glutaminase activity
T	0005829	cellular_component	cytosol
T	0006543	biological_process	L-glutamine catabolic process
T	0008614	biological_process	pyridoxine metabolic process
T	0016787	molecular_function	hydrolase activity
T	0016829	molecular_function	lyase activity
T	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
T	0042819	biological_process	vitamin B6 biosynthetic process
T	0042823	biological_process	pyridoxal phosphate biosynthetic process
T	1903600	cellular_component	glutaminase complex
U	0004359	molecular_function	glutaminase activity
U	0005829	cellular_component	cytosol
U	0006543	biological_process	L-glutamine catabolic process
U	0008614	biological_process	pyridoxine metabolic process
U	0016787	molecular_function	hydrolase activity
U	0016829	molecular_function	lyase activity
U	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
U	0042819	biological_process	vitamin B6 biosynthetic process
U	0042823	biological_process	pyridoxal phosphate biosynthetic process
U	1903600	cellular_component	glutaminase complex
V	0004359	molecular_function	glutaminase activity
V	0005829	cellular_component	cytosol
V	0006543	biological_process	L-glutamine catabolic process
V	0008614	biological_process	pyridoxine metabolic process
V	0016787	molecular_function	hydrolase activity
V	0016829	molecular_function	lyase activity
V	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
V	0042819	biological_process	vitamin B6 biosynthetic process
V	0042823	biological_process	pyridoxal phosphate biosynthetic process
V	1903600	cellular_component	glutaminase complex
W	0004359	molecular_function	glutaminase activity
W	0005829	cellular_component	cytosol
W	0006543	biological_process	L-glutamine catabolic process
W	0008614	biological_process	pyridoxine metabolic process
W	0016787	molecular_function	hydrolase activity
W	0016829	molecular_function	lyase activity
W	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
W	0042819	biological_process	vitamin B6 biosynthetic process
W	0042823	biological_process	pyridoxal phosphate biosynthetic process
W	1903600	cellular_component	glutaminase complex
X	0004359	molecular_function	glutaminase activity
X	0005829	cellular_component	cytosol
X	0006543	biological_process	L-glutamine catabolic process
X	0008614	biological_process	pyridoxine metabolic process
X	0016787	molecular_function	hydrolase activity
X	0016829	molecular_function	lyase activity
X	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
X	0042819	biological_process	vitamin B6 biosynthetic process
X	0042823	biological_process	pyridoxal phosphate biosynthetic process
X	1903600	cellular_component	glutaminase complex

Functional Information from PROSITE/UniProt

site_id	PS01235
Number of Residues	19
Details	PDXS_SNZ_1 PdxS/SNZ family signature. LPVVNFAAGGVATPQDAAL

Chain	Residue	Details
A	LEU206-LEU224

---

site_id	PS01236
Number of Residues	11
Details	PDXT_SNO_1 PdxT/SNO family family signature. GLILPGGESTT

Chain	Residue	Details
T	GLY40-THR50

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Schiff-base intermediate with D-ribose 5-phosphate","evidences":[{"source":"HAMAP-Rule","id":"MF_01824","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01824","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01615","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_01615","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01615","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---