Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8U7J

Crystal Structure of Staphylococcus aureus PLP synthase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006520	biological_process	amino acid metabolic process
A	0008615	biological_process	pyridoxine biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016843	molecular_function	amine-lyase activity
A	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0008615	biological_process	pyridoxine biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016843	molecular_function	amine-lyase activity
B	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
B	0042823	biological_process	pyridoxal phosphate biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0008615	biological_process	pyridoxine biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016843	molecular_function	amine-lyase activity
C	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
C	0042823	biological_process	pyridoxal phosphate biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0008615	biological_process	pyridoxine biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016843	molecular_function	amine-lyase activity
D	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
D	0042823	biological_process	pyridoxal phosphate biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0008615	biological_process	pyridoxine biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016843	molecular_function	amine-lyase activity
E	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
E	0042823	biological_process	pyridoxal phosphate biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0008615	biological_process	pyridoxine biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016843	molecular_function	amine-lyase activity
F	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
F	0042823	biological_process	pyridoxal phosphate biosynthetic process
G	0006520	biological_process	amino acid metabolic process
G	0008615	biological_process	pyridoxine biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016843	molecular_function	amine-lyase activity
G	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
G	0042823	biological_process	pyridoxal phosphate biosynthetic process
H	0006520	biological_process	amino acid metabolic process
H	0008615	biological_process	pyridoxine biosynthetic process
H	0016829	molecular_function	lyase activity
H	0016843	molecular_function	amine-lyase activity
H	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
H	0042823	biological_process	pyridoxal phosphate biosynthetic process
I	0006520	biological_process	amino acid metabolic process
I	0008615	biological_process	pyridoxine biosynthetic process
I	0016829	molecular_function	lyase activity
I	0016843	molecular_function	amine-lyase activity
I	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
I	0042823	biological_process	pyridoxal phosphate biosynthetic process
J	0006520	biological_process	amino acid metabolic process
J	0008615	biological_process	pyridoxine biosynthetic process
J	0016829	molecular_function	lyase activity
J	0016843	molecular_function	amine-lyase activity
J	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
J	0042823	biological_process	pyridoxal phosphate biosynthetic process
K	0006520	biological_process	amino acid metabolic process
K	0008615	biological_process	pyridoxine biosynthetic process
K	0016829	molecular_function	lyase activity
K	0016843	molecular_function	amine-lyase activity
K	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
K	0042823	biological_process	pyridoxal phosphate biosynthetic process
L	0006520	biological_process	amino acid metabolic process
L	0008615	biological_process	pyridoxine biosynthetic process
L	0016829	molecular_function	lyase activity
L	0016843	molecular_function	amine-lyase activity
L	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
L	0042823	biological_process	pyridoxal phosphate biosynthetic process
M	0004359	molecular_function	glutaminase activity
M	0005829	cellular_component	cytosol
M	0006541	biological_process	glutamine metabolic process
M	0006543	biological_process	glutamine catabolic process
M	0008614	biological_process	pyridoxine metabolic process
M	0016787	molecular_function	hydrolase activity
M	0016829	molecular_function	lyase activity
M	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
M	0042823	biological_process	pyridoxal phosphate biosynthetic process
M	1903600	cellular_component	glutaminase complex
N	0004359	molecular_function	glutaminase activity
N	0005829	cellular_component	cytosol
N	0006541	biological_process	glutamine metabolic process
N	0006543	biological_process	glutamine catabolic process
N	0008614	biological_process	pyridoxine metabolic process
N	0016787	molecular_function	hydrolase activity
N	0016829	molecular_function	lyase activity
N	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
N	0042823	biological_process	pyridoxal phosphate biosynthetic process
N	1903600	cellular_component	glutaminase complex
O	0004359	molecular_function	glutaminase activity
O	0005829	cellular_component	cytosol
O	0006541	biological_process	glutamine metabolic process
O	0006543	biological_process	glutamine catabolic process
O	0008614	biological_process	pyridoxine metabolic process
O	0016787	molecular_function	hydrolase activity
O	0016829	molecular_function	lyase activity
O	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
O	0042823	biological_process	pyridoxal phosphate biosynthetic process
O	1903600	cellular_component	glutaminase complex
P	0004359	molecular_function	glutaminase activity
P	0005829	cellular_component	cytosol
P	0006541	biological_process	glutamine metabolic process
P	0006543	biological_process	glutamine catabolic process
P	0008614	biological_process	pyridoxine metabolic process
P	0016787	molecular_function	hydrolase activity
P	0016829	molecular_function	lyase activity
P	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
P	0042823	biological_process	pyridoxal phosphate biosynthetic process
P	1903600	cellular_component	glutaminase complex
Q	0004359	molecular_function	glutaminase activity
Q	0005829	cellular_component	cytosol
Q	0006541	biological_process	glutamine metabolic process
Q	0006543	biological_process	glutamine catabolic process
Q	0008614	biological_process	pyridoxine metabolic process
Q	0016787	molecular_function	hydrolase activity
Q	0016829	molecular_function	lyase activity
Q	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Q	0042823	biological_process	pyridoxal phosphate biosynthetic process
Q	1903600	cellular_component	glutaminase complex
R	0004359	molecular_function	glutaminase activity
R	0005829	cellular_component	cytosol
R	0006541	biological_process	glutamine metabolic process
R	0006543	biological_process	glutamine catabolic process
R	0008614	biological_process	pyridoxine metabolic process
R	0016787	molecular_function	hydrolase activity
R	0016829	molecular_function	lyase activity
R	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
R	0042823	biological_process	pyridoxal phosphate biosynthetic process
R	1903600	cellular_component	glutaminase complex
S	0004359	molecular_function	glutaminase activity
S	0005829	cellular_component	cytosol
S	0006541	biological_process	glutamine metabolic process
S	0006543	biological_process	glutamine catabolic process
S	0008614	biological_process	pyridoxine metabolic process
S	0016787	molecular_function	hydrolase activity
S	0016829	molecular_function	lyase activity
S	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
S	0042823	biological_process	pyridoxal phosphate biosynthetic process
S	1903600	cellular_component	glutaminase complex
T	0004359	molecular_function	glutaminase activity
T	0005829	cellular_component	cytosol
T	0006541	biological_process	glutamine metabolic process
T	0006543	biological_process	glutamine catabolic process
T	0008614	biological_process	pyridoxine metabolic process
T	0016787	molecular_function	hydrolase activity
T	0016829	molecular_function	lyase activity
T	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
T	0042823	biological_process	pyridoxal phosphate biosynthetic process
T	1903600	cellular_component	glutaminase complex
U	0004359	molecular_function	glutaminase activity
U	0005829	cellular_component	cytosol
U	0006541	biological_process	glutamine metabolic process
U	0006543	biological_process	glutamine catabolic process
U	0008614	biological_process	pyridoxine metabolic process
U	0016787	molecular_function	hydrolase activity
U	0016829	molecular_function	lyase activity
U	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
U	0042823	biological_process	pyridoxal phosphate biosynthetic process
U	1903600	cellular_component	glutaminase complex
V	0004359	molecular_function	glutaminase activity
V	0005829	cellular_component	cytosol
V	0006541	biological_process	glutamine metabolic process
V	0006543	biological_process	glutamine catabolic process
V	0008614	biological_process	pyridoxine metabolic process
V	0016787	molecular_function	hydrolase activity
V	0016829	molecular_function	lyase activity
V	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
V	0042823	biological_process	pyridoxal phosphate biosynthetic process
V	1903600	cellular_component	glutaminase complex
W	0004359	molecular_function	glutaminase activity
W	0005829	cellular_component	cytosol
W	0006541	biological_process	glutamine metabolic process
W	0006543	biological_process	glutamine catabolic process
W	0008614	biological_process	pyridoxine metabolic process
W	0016787	molecular_function	hydrolase activity
W	0016829	molecular_function	lyase activity
W	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
W	0042823	biological_process	pyridoxal phosphate biosynthetic process
W	1903600	cellular_component	glutaminase complex
X	0004359	molecular_function	glutaminase activity
X	0005829	cellular_component	cytosol
X	0006541	biological_process	glutamine metabolic process
X	0006543	biological_process	glutamine catabolic process
X	0008614	biological_process	pyridoxine metabolic process
X	0016787	molecular_function	hydrolase activity
X	0016829	molecular_function	lyase activity
X	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
X	0042823	biological_process	pyridoxal phosphate biosynthetic process
X	1903600	cellular_component	glutaminase complex

Functional Information from PROSITE/UniProt

site_id	PS01235
Number of Residues	19
Details	PDXS_SNZ_1 PdxS/SNZ family signature. LPVVNFAAGGVATPQDAAL

Chain	Residue	Details
A	LEU206-LEU224

site_id	PS01236
Number of Residues	11
Details	PDXT_SNO_1 PdxT/SNO family family signature. GLILPGGESTT

Chain	Residue	Details
T	GLY40-THR50

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_01615

Chain	Residue	Details
T	CYS75
U	CYS75
P	CYS75
Q	CYS75
N	CYS75
S	CYS75
X	CYS75
R	CYS75
W	CYS75
O	CYS75
M	CYS75
V	CYS75

site_id	SWS_FT_FI2
Number of Residues	24
Details	ACT_SITE: Charge relay system => ECO:0000255\|HAMAP-Rule:MF_01615

Chain	Residue	Details
T	ASN165
R	GLU167
W	ASN165
W	GLU167
O	ASN165
O	GLU167
M	ASN165
M	GLU167
V	ASN165
V	GLU167
U	ASN165
T	GLU167
U	GLU167
P	ASN165
P	GLU167
Q	ASN165
Q	GLU167
K	GLY236
F	ASP25
F	GLY154
F	ARG166
F	GLY215
N	ASN165
F	GLY236
J	ASP25
J	GLY154
J	ARG166
J	GLY215
J	GLY236
C	ASP25
C	GLY154
C	ARG166
C	GLY215
N	GLU167
C	GLY236
I	ASP25
I	GLY154
I	ARG166
I	GLY215
I	GLY236
H	ASP25
H	GLY154
H	ARG166
H	GLY215
S	ASN165
H	GLY236
D	ASP25
D	GLY154
D	ARG166
D	GLY215
D	GLY236
E	ASP25
E	GLY154
E	ARG166
E	GLY215
S	GLU167
E	GLY236
X	ASN165
X	GLU167
R	ASN165

site_id	SWS_FT_FI3
Number of Residues	36
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01615

Chain	Residue	Details
T	GLY46
X	GLY46
X	ARG101
X	ILE129
R	GLY46
R	ARG101
R	ILE129
W	GLY46
W	ARG101
W	ILE129
O	GLY46
T	ARG101
O	ARG101
O	ILE129
M	GLY46
M	ARG101
M	ILE129
V	GLY46
V	ARG101
V	ILE129
U	GLY46
U	ARG101
T	ILE129
U	ILE129
P	GLY46
P	ARG101
P	ILE129
Q	GLY46
Q	ARG101
Q	ILE129
N	GLY46
N	ARG101
N	ILE129
S	GLY46
S	ARG101
S	ILE129

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)