8U3A
TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 1 (monomer)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 44 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"10931826","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9R186","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"PubMed","id":"11884385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
