8U02
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlNLCAISIDRYTaV |
| Chain | Residue | Details |
| R | ALA120-VAL136 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| A | LEU70-SER84 | |
| A | ILE157-ILE171 | |
| A | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| C | ALA2 | |
| B | SER47 | |
| B | LEU176 | |
| B | THR182 | |
| B | ASP201 | |
| B | ASN270 | |
| B | ALA326 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212 |
| Chain | Residue | Details |
| C | CYS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | LIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212 |
| Chain | Residue | Details |
| C | CYS68 | |
| R | ASP131-ARG151 | |
| R | ILE214-GLN373 | |
| R | GLU432-CYS443 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250 |
| Chain | Residue | Details |
| B | CYS351 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805 |
| Chain | Residue | Details |
| B | GLY2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| B | CYS3 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250 |
| Chain | Residue | Details |
| R | PHE189-TYR213 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250 |
| Chain | Residue | Details |
| R | MET374-LEU395 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250 |
| Chain | Residue | Details |
| R | ALA410-ILE431 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | SITE: Important for receptor activation => ECO:0000250 |
| Chain | Residue | Details |
| R | SER194 | |
| R | SER197 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:26535572 |
| Chain | Residue | Details |
| R | CYS443 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN5 | |
| R | ASN17 | |
| R | ASN23 |
