8TZI
Human equilibrative nucleoside transporter-1, JH-ENT-01 bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001504 | biological_process | neurotransmitter uptake |
| A | 0005326 | molecular_function | neurotransmitter transmembrane transporter activity |
| A | 0005337 | molecular_function | nucleoside transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006855 | biological_process | xenobiotic transmembrane transport |
| A | 0007595 | biological_process | lactation |
| A | 0015207 | molecular_function | adenine transmembrane transporter activity |
| A | 0015208 | molecular_function | guanine transmembrane transporter activity |
| A | 0015210 | molecular_function | uracil transmembrane transporter activity |
| A | 0015211 | molecular_function | purine nucleoside transmembrane transporter activity |
| A | 0015212 | molecular_function | cytidine transmembrane transporter activity |
| A | 0015213 | molecular_function | uridine transmembrane transporter activity |
| A | 0015389 | molecular_function | pyrimidine- and adenosine-specific:sodium symporter activity |
| A | 0015851 | biological_process | nucleobase transport |
| A | 0015853 | biological_process | adenine transport |
| A | 0015858 | biological_process | nucleoside transport |
| A | 0015860 | biological_process | purine nucleoside transmembrane transport |
| A | 0015861 | biological_process | cytidine transport |
| A | 0015862 | biological_process | uridine transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0032238 | biological_process | adenosine transport |
| A | 0035340 | biological_process | inosine transport |
| A | 0035344 | biological_process | hypoxanthine transport |
| A | 0035364 | biological_process | thymine transport |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0060079 | biological_process | excitatory postsynaptic potential |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 0072531 | biological_process | pyrimidine-containing compound transmembrane transport |
| A | 0098793 | cellular_component | presynapse |
| A | 0098794 | cellular_component | postsynapse |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1901642 | biological_process | nucleoside transmembrane transport |
| A | 1903716 | biological_process | guanine transmembrane transport |
| A | 1903791 | biological_process | uracil transmembrane transport |
| A | 1904082 | biological_process | pyrimidine nucleobase transmembrane transport |
| A | 1904823 | biological_process | purine nucleobase transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"11584005","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 35 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"11584005","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 15 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"31235912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"11584005","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for nucleobase transport","evidences":[{"source":"PubMed","id":"21795683","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11584005","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
