8TWA

Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-PolE-DNA complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000166	molecular_function	nucleotide binding
1	0000724	biological_process	double-strand break repair via homologous recombination
1	0003677	molecular_function	DNA binding
1	0003689	molecular_function	DNA clamp loader activity
1	0005515	molecular_function	protein binding
1	0005524	molecular_function	ATP binding
1	0005634	cellular_component	nucleus
1	0005739	cellular_component	mitochondrion
1	0006260	biological_process	DNA replication
1	0006270	biological_process	DNA replication initiation
1	0007064	biological_process	mitotic sister chromatid cohesion
1	0016887	molecular_function	ATP hydrolysis activity
1	0031390	cellular_component	Ctf18 RFC-like complex
1	0034398	biological_process	telomere tethering at nuclear periphery
1	0035753	biological_process	maintenance of DNA trinucleotide repeats
1	0043596	cellular_component	nuclear replication fork
2	0000076	biological_process	DNA replication checkpoint signaling
2	0000077	biological_process	DNA damage checkpoint signaling
2	0000166	molecular_function	nucleotide binding
2	0003677	molecular_function	DNA binding
2	0003689	molecular_function	DNA clamp loader activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005663	cellular_component	DNA replication factor C complex
2	0006260	biological_process	DNA replication
2	0006261	biological_process	DNA-templated DNA replication
2	0006271	biological_process	DNA strand elongation involved in DNA replication
2	0006272	biological_process	leading strand elongation
2	0006281	biological_process	DNA repair
2	0006298	biological_process	mismatch repair
2	0007062	biological_process	sister chromatid cohesion
2	0007064	biological_process	mitotic sister chromatid cohesion
2	0016887	molecular_function	ATP hydrolysis activity
2	0031389	cellular_component	Rad17 RFC-like complex
2	0031390	cellular_component	Ctf18 RFC-like complex
2	0031391	cellular_component	Elg1 RFC-like complex
3	0000077	biological_process	DNA damage checkpoint signaling
3	0000166	molecular_function	nucleotide binding
3	0003677	molecular_function	DNA binding
3	0003689	molecular_function	DNA clamp loader activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005663	cellular_component	DNA replication factor C complex
3	0005829	cellular_component	cytosol
3	0006260	biological_process	DNA replication
3	0006261	biological_process	DNA-templated DNA replication
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006272	biological_process	leading strand elongation
3	0006281	biological_process	DNA repair
3	0006298	biological_process	mismatch repair
3	0007064	biological_process	mitotic sister chromatid cohesion
3	0016887	molecular_function	ATP hydrolysis activity
3	0031389	cellular_component	Rad17 RFC-like complex
3	0031390	cellular_component	Ctf18 RFC-like complex
3	0031391	cellular_component	Elg1 RFC-like complex
4	0000077	biological_process	DNA damage checkpoint signaling
4	0000166	molecular_function	nucleotide binding
4	0003677	molecular_function	DNA binding
4	0003689	molecular_function	DNA clamp loader activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005663	cellular_component	DNA replication factor C complex
4	0005829	cellular_component	cytosol
4	0006260	biological_process	DNA replication
4	0006261	biological_process	DNA-templated DNA replication
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006272	biological_process	leading strand elongation
4	0006281	biological_process	DNA repair
4	0007062	biological_process	sister chromatid cohesion
4	0007064	biological_process	mitotic sister chromatid cohesion
4	0016887	molecular_function	ATP hydrolysis activity
4	0031389	cellular_component	Rad17 RFC-like complex
4	0031390	cellular_component	Ctf18 RFC-like complex
4	0031391	cellular_component	Elg1 RFC-like complex
5	0000077	biological_process	DNA damage checkpoint signaling
5	0000166	molecular_function	nucleotide binding
5	0003677	molecular_function	DNA binding
5	0003689	molecular_function	DNA clamp loader activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005663	cellular_component	DNA replication factor C complex
5	0006260	biological_process	DNA replication
5	0006261	biological_process	DNA-templated DNA replication
5	0006271	biological_process	DNA strand elongation involved in DNA replication
5	0006272	biological_process	leading strand elongation
5	0006281	biological_process	DNA repair
5	0007062	biological_process	sister chromatid cohesion
5	0007064	biological_process	mitotic sister chromatid cohesion
5	0031389	cellular_component	Rad17 RFC-like complex
5	0031390	cellular_component	Ctf18 RFC-like complex
5	0031391	cellular_component	Elg1 RFC-like complex
B	0000775	cellular_component	chromosome, centromeric region
B	0000785	cellular_component	chromatin
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0006260	biological_process	DNA replication
B	0007064	biological_process	mitotic sister chromatid cohesion
B	0031390	cellular_component	Ctf18 RFC-like complex
B	0034088	biological_process	maintenance of mitotic sister chromatid cohesion
B	0034398	biological_process	telomere tethering at nuclear periphery
B	0035753	biological_process	maintenance of DNA trinucleotide repeats
D	0003674	molecular_function	molecular_function
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006260	biological_process	DNA replication
D	0007064	biological_process	mitotic sister chromatid cohesion
D	0031390	cellular_component	Ctf18 RFC-like complex
D	0034398	biological_process	telomere tethering at nuclear periphery
D	0035753	biological_process	maintenance of DNA trinucleotide repeats
E	0000166	molecular_function	nucleotide binding
E	0000278	biological_process	mitotic cell cycle
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0003729	molecular_function	mRNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005657	cellular_component	replication fork
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006272	biological_process	leading strand elongation
E	0006281	biological_process	DNA repair
E	0006284	biological_process	base-excision repair
E	0006287	biological_process	base-excision repair, gap-filling
E	0006297	biological_process	nucleotide-excision repair, DNA gap filling
E	0006302	biological_process	double-strand break repair
E	0006303	biological_process	double-strand break repair via nonhomologous end joining
E	0007064	biological_process	mitotic sister chromatid cohesion
E	0008270	molecular_function	zinc ion binding
E	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
E	0008622	cellular_component	epsilon DNA polymerase complex
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0016787	molecular_function	hydrolase activity
E	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
E	0032183	molecular_function	SUMO binding
E	0033314	biological_process	mitotic DNA replication checkpoint signaling
E	0034061	molecular_function	DNA polymerase activity
E	0035822	biological_process	gene conversion
E	0042276	biological_process	error-prone translesion synthesis
E	0043596	cellular_component	nuclear replication fork
E	0045004	biological_process	DNA replication proofreading
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051539	molecular_function	4 iron, 4 sulfur cluster binding
X	0000278	biological_process	mitotic cell cycle
X	0000710	biological_process	meiotic mismatch repair
X	0000781	cellular_component	chromosome, telomeric region
X	0003677	molecular_function	DNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005657	cellular_component	replication fork
X	0006260	biological_process	DNA replication
X	0006272	biological_process	leading strand elongation
X	0006273	biological_process	lagging strand elongation
X	0006275	biological_process	regulation of DNA replication
X	0006289	biological_process	nucleotide-excision repair
X	0006298	biological_process	mismatch repair
X	0006301	biological_process	DNA damage tolerance
X	0006974	biological_process	DNA damage response
X	0007064	biological_process	mitotic sister chromatid cohesion
X	0019985	biological_process	translesion synthesis
X	0030337	molecular_function	DNA polymerase processivity factor activity
X	0030466	biological_process	silent mating-type cassette heterochromatin formation
X	0031509	biological_process	subtelomeric heterochromatin formation
X	0034087	biological_process	establishment of mitotic sister chromatid cohesion
X	0035753	biological_process	maintenance of DNA trinucleotide repeats
X	0042802	molecular_function	identical protein binding
X	0043626	cellular_component	PCNA complex
X	0045739	biological_process	positive regulation of DNA repair
X	0045740	biological_process	positive regulation of DNA replication
X	0051054	biological_process	positive regulation of DNA metabolic process
X	0070987	biological_process	error-free translesion synthesis
Y	0000278	biological_process	mitotic cell cycle
Y	0000710	biological_process	meiotic mismatch repair
Y	0000781	cellular_component	chromosome, telomeric region
Y	0003677	molecular_function	DNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005657	cellular_component	replication fork
Y	0006260	biological_process	DNA replication
Y	0006272	biological_process	leading strand elongation
Y	0006273	biological_process	lagging strand elongation
Y	0006275	biological_process	regulation of DNA replication
Y	0006289	biological_process	nucleotide-excision repair
Y	0006298	biological_process	mismatch repair
Y	0006301	biological_process	DNA damage tolerance
Y	0006974	biological_process	DNA damage response
Y	0007064	biological_process	mitotic sister chromatid cohesion
Y	0019985	biological_process	translesion synthesis
Y	0030337	molecular_function	DNA polymerase processivity factor activity
Y	0030466	biological_process	silent mating-type cassette heterochromatin formation
Y	0031509	biological_process	subtelomeric heterochromatin formation
Y	0034087	biological_process	establishment of mitotic sister chromatid cohesion
Y	0035753	biological_process	maintenance of DNA trinucleotide repeats
Y	0042802	molecular_function	identical protein binding
Y	0043626	cellular_component	PCNA complex
Y	0045739	biological_process	positive regulation of DNA repair
Y	0045740	biological_process	positive regulation of DNA replication
Y	0051054	biological_process	positive regulation of DNA metabolic process
Y	0070987	biological_process	error-free translesion synthesis
Z	0000278	biological_process	mitotic cell cycle
Z	0000710	biological_process	meiotic mismatch repair
Z	0000781	cellular_component	chromosome, telomeric region
Z	0003677	molecular_function	DNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005657	cellular_component	replication fork
Z	0006260	biological_process	DNA replication
Z	0006272	biological_process	leading strand elongation
Z	0006273	biological_process	lagging strand elongation
Z	0006275	biological_process	regulation of DNA replication
Z	0006289	biological_process	nucleotide-excision repair
Z	0006298	biological_process	mismatch repair
Z	0006301	biological_process	DNA damage tolerance
Z	0006974	biological_process	DNA damage response
Z	0007064	biological_process	mitotic sister chromatid cohesion
Z	0019985	biological_process	translesion synthesis
Z	0030337	molecular_function	DNA polymerase processivity factor activity
Z	0030466	biological_process	silent mating-type cassette heterochromatin formation
Z	0031509	biological_process	subtelomeric heterochromatin formation
Z	0034087	biological_process	establishment of mitotic sister chromatid cohesion
Z	0035753	biological_process	maintenance of DNA trinucleotide repeats
Z	0042802	molecular_function	identical protein binding
Z	0043626	cellular_component	PCNA complex
Z	0045739	biological_process	positive regulation of DNA repair
Z	0045740	biological_process	positive regulation of DNA replication
Z	0051054	biological_process	positive regulation of DNA metabolic process
Z	0070987	biological_process	error-free translesion synthesis

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDHpvtLgmdLtSLsKIL

Chain	Residue	Details
X	ARG61-LEU79

---

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GIiAqAVDdSRVlLVsLeIgveaF

Chain	Residue	Details
X	GLY34-PHE57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	57
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"15166219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"12226657","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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