8TUA

Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006801	biological_process	superoxide metabolic process
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0019899	molecular_function	enzyme binding
A	0030041	biological_process	actin filament polymerization
A	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
A	0030335	biological_process	positive regulation of cell migration
A	0030426	cellular_component	growth cone
A	0030833	biological_process	regulation of actin filament polymerization
A	0032007	biological_process	negative regulation of TOR signaling
A	0035556	biological_process	intracellular signal transduction
A	0042119	biological_process	neutrophil activation
A	0043198	cellular_component	dendritic shaft
A	0045321	biological_process	leukocyte activation
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050773	biological_process	regulation of dendrite development
A	0051056	biological_process	regulation of small GTPase mediated signal transduction
A	0072593	biological_process	reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00741
Number of Residues	26
Details	DH_1 Dbl homology (DH) domain signature. LegYLlsPIqrIcKypLlLkELakrT

Chain	Residue	Details
A	LEU188-THR213

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---