8TR1
Crystal structure of trypanosome brucei hypoxanthine guanine phosphopribosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2- phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLVLEDILDTAlT |
| Chain | Residue | Details |
| A | VAL109-THR121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP117 | |
| B | ASP117 | |
| C | ASP117 | |
| D | ASP117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS54 | |
| C | GLU113 | |
| C | LYS145 | |
| C | ASP173 | |
| D | LYS54 | |
| D | GLU113 | |
| D | LYS145 | |
| D | ASP173 | |
| A | GLU113 | |
| A | LYS145 | |
| A | ASP173 | |
| B | LYS54 | |
| B | GLU113 | |
| B | LYS145 | |
| B | ASP173 | |
| C | LYS54 |
