Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8TQ2

Structure of the kinase lobe of human CDK8 kinase module

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0006468	biological_process	protein phosphorylation
A	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
A	0016301	molecular_function	kinase activity
A	0016592	cellular_component	mediator complex
A	0016740	molecular_function	transferase activity
A	0032991	cellular_component	protein-containing complex
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051726	biological_process	regulation of cell cycle
A	0106310	molecular_function	protein serine kinase activity
A	1990508	cellular_component	CKM complex
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
B	0016592	cellular_component	mediator complex
B	0042802	molecular_function	identical protein binding
B	0045023	biological_process	G0 to G1 transition
B	0045746	biological_process	negative regulation of Notch signaling pathway
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	1990508	cellular_component	CKM complex
C	0000151	cellular_component	ubiquitin ligase complex
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0001756	biological_process	somitogenesis
C	0001843	biological_process	neural tube closure
C	0003682	molecular_function	chromatin binding
C	0003712	molecular_function	transcription coregulator activity
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0007492	biological_process	endoderm development
C	0007507	biological_process	heart development
C	0008013	molecular_function	beta-catenin binding
C	0014003	biological_process	oligodendrocyte development
C	0014044	biological_process	Schwann cell development
C	0016020	cellular_component	membrane
C	0016567	biological_process	protein ubiquitination
C	0016592	cellular_component	mediator complex
C	0021510	biological_process	spinal cord development
C	0021915	biological_process	neural tube development
C	0035019	biological_process	somatic stem cell population maintenance
C	0036342	biological_process	post-anal tail morphogenesis
C	0042809	molecular_function	nuclear vitamin D receptor binding
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046966	molecular_function	nuclear thyroid hormone receptor binding
C	0048568	biological_process	embryonic organ development
C	0048702	biological_process	embryonic neurocranium morphogenesis
C	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0090245	biological_process	axis elongation involved in somitogenesis
C	1990403	biological_process	embryonic brain development
C	1990508	cellular_component	CKM complex
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0003712	molecular_function	transcription coregulator activity
D	0003713	molecular_function	transcription coactivator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016020	cellular_component	membrane
D	0016592	cellular_component	mediator complex
D	0042632	biological_process	cholesterol homeostasis
D	0042809	molecular_function	nuclear vitamin D receptor binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046966	molecular_function	nuclear thyroid hormone receptor binding
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0070328	biological_process	triglyceride homeostasis
D	1990508	cellular_component	CKM complex

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	26
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK

Chain	Residue	Details
A	VAL27-LYS52

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV

Chain	Residue	Details
A	VAL147-VAL159

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"A2AGH6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Region: {"description":"Interaction with CCNC"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)