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8TK4

HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0001772cellular_componentimmunological synapse
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005929cellular_componentcilium
A0006470biological_processprotein dephosphorylation
A0008092molecular_functioncytoskeletal protein binding
A0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
A0009968biological_processnegative regulation of signal transduction
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0019901molecular_functionprotein kinase binding
A0030294molecular_functionreceptor signaling protein tyrosine kinase inhibitor activity
A0030336biological_processnegative regulation of cell migration
A0030971molecular_functionreceptor tyrosine kinase binding
A0031514cellular_componentmotile cilium
A0033549molecular_functionMAP kinase phosphatase activity
A0035335biological_processpeptidyl-tyrosine dephosphorylation
A0042059biological_processnegative regulation of epidermal growth factor receptor signaling pathway
A0042995cellular_componentcell projection
A0043409biological_processnegative regulation of MAPK cascade
A0045931biological_processpositive regulation of mitotic cell cycle
A0046329biological_processnegative regulation of JNK cascade
A0050860biological_processnegative regulation of T cell receptor signaling pathway
A0050868biological_processnegative regulation of T cell activation
A0050922biological_processnegative regulation of chemotaxis
A0051893biological_processregulation of focal adhesion assembly
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0071364biological_processcellular response to epidermal growth factor stimulus
A0120183biological_processpositive regulation of focal adhesion disassembly
A1990782molecular_functionprotein tyrosine kinase binding
Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCreGysRSP
ChainResidueDetails
AVAL122-PRO132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160
ChainResidueDetails
ACYS124

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PDB entries from 2025-06-11

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