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8TIL

Human ACKR3 phosphorylated by GRK5 in complex with Arrestin3 reconstructed without receptor/micelle

Functional Information from GO Data
ChainGOidnamespacecontents
A0000822molecular_functioninositol hexakisphosphate binding
A0001664molecular_functionG protein-coupled receptor binding
A0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006898biological_processreceptor-mediated endocytosis
A0007165biological_processsignal transduction
A0008277biological_processregulation of G protein-coupled receptor signaling pathway
A0009968biological_processnegative regulation of signal transduction
A0015031biological_processprotein transport
A0019233biological_processsensory perception of pain
A0030139cellular_componentendocytic vesicle
A0031410cellular_componentcytoplasmic vesicle
A0031623biological_processreceptor internalization
A0031701molecular_functionangiotensin receptor binding
A0031748molecular_functionD1 dopamine receptor binding
A0035091molecular_functionphosphatidylinositol binding
A0050804biological_processmodulation of chemical synaptic transmission
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0001525biological_processangiogenesis
R0001570biological_processvasculogenesis
R0004930molecular_functionG protein-coupled receptor activity
R0005044molecular_functionscavenger receptor activity
R0005515molecular_functionprotein binding
R0005768cellular_componentendosome
R0005769cellular_componentearly endosome
R0005886cellular_componentplasma membrane
R0005905cellular_componentclathrin-coated pit
R0006935biological_processchemotaxis
R0006955biological_processimmune response
R0007155biological_processcell adhesion
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0008285biological_processnegative regulation of cell population proliferation
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0015026molecular_functioncoreceptor activity
R0016020cellular_componentmembrane
R0016493molecular_functionC-C chemokine receptor activity
R0016494molecular_functionC-X-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0019956molecular_functionchemokine binding
R0019957molecular_functionC-C chemokine binding
R0019958molecular_functionC-X-C chemokine binding
R0021557biological_processoculomotor nerve development
R0031623biological_processreceptor internalization
R0055037cellular_componentrecycling endosome
R0060326biological_processcell chemotaxis
R0070098biological_processchemokine-mediated signaling pathway
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
R1905322biological_processpositive regulation of mesenchymal stem cell migration
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSIfFLTCMSVDRYLsI
ChainResidueDetails
RGLY144-ILE160

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR193-HIS199
HTYR213-HIS219

site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLsFrKDL
ChainResidueDetails
APHE62-LEU80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q91YI4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Hydroxyproline; by PHD2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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