8TDW

ssRNA bound SAMHD1 T open

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0003676	molecular_function	nucleic acid binding
A	0003697	molecular_function	single-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0004540	molecular_function	RNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005886	cellular_component	plasma membrane
A	0006203	biological_process	dGTP catabolic process
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006955	biological_process	immune response
A	0006974	biological_process	DNA damage response
A	0008270	molecular_function	zinc ion binding
A	0008832	molecular_function	dGTPase activity
A	0009264	biological_process	deoxyribonucleotide catabolic process
A	0016446	biological_process	somatic hypermutation of immunoglobulin genes
A	0016787	molecular_function	hydrolase activity
A	0016793	molecular_function	triphosphoric monoester hydrolase activity
A	0032567	molecular_function	dGTP binding
A	0035861	cellular_component	site of double-strand break
A	0042802	molecular_function	identical protein binding
A	0045087	biological_process	innate immune response
A	0045088	biological_process	regulation of innate immune response
A	0046061	biological_process	dATP catabolic process
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0051607	biological_process	defense response to virus
A	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
A	0097197	cellular_component	tetraspanin-enriched microdomain
A	0106375	molecular_function	deoxynucleoside triphosphate hydrolase activity
A	0110025	biological_process	DNA strand resection involved in replication fork processing
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0003676	molecular_function	nucleic acid binding
B	0003697	molecular_function	single-stranded DNA binding
B	0003723	molecular_function	RNA binding
B	0004540	molecular_function	RNA nuclease activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005886	cellular_component	plasma membrane
B	0006203	biological_process	dGTP catabolic process
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006955	biological_process	immune response
B	0006974	biological_process	DNA damage response
B	0008270	molecular_function	zinc ion binding
B	0008832	molecular_function	dGTPase activity
B	0009264	biological_process	deoxyribonucleotide catabolic process
B	0016446	biological_process	somatic hypermutation of immunoglobulin genes
B	0016787	molecular_function	hydrolase activity
B	0016793	molecular_function	triphosphoric monoester hydrolase activity
B	0032567	molecular_function	dGTP binding
B	0035861	cellular_component	site of double-strand break
B	0042802	molecular_function	identical protein binding
B	0045087	biological_process	innate immune response
B	0045088	biological_process	regulation of innate immune response
B	0046061	biological_process	dATP catabolic process
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0051607	biological_process	defense response to virus
B	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
B	0097197	cellular_component	tetraspanin-enriched microdomain
B	0106375	molecular_function	deoxynucleoside triphosphate hydrolase activity
B	0110025	biological_process	DNA strand resection involved in replication fork processing
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0003676	molecular_function	nucleic acid binding
E	0003697	molecular_function	single-stranded DNA binding
E	0003723	molecular_function	RNA binding
E	0004540	molecular_function	RNA nuclease activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005886	cellular_component	plasma membrane
E	0006203	biological_process	dGTP catabolic process
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006955	biological_process	immune response
E	0006974	biological_process	DNA damage response
E	0008270	molecular_function	zinc ion binding
E	0008832	molecular_function	dGTPase activity
E	0009264	biological_process	deoxyribonucleotide catabolic process
E	0016446	biological_process	somatic hypermutation of immunoglobulin genes
E	0016787	molecular_function	hydrolase activity
E	0016793	molecular_function	triphosphoric monoester hydrolase activity
E	0032567	molecular_function	dGTP binding
E	0035861	cellular_component	site of double-strand break
E	0042802	molecular_function	identical protein binding
E	0045087	biological_process	innate immune response
E	0045088	biological_process	regulation of innate immune response
E	0046061	biological_process	dATP catabolic process
E	0046872	molecular_function	metal ion binding
E	0051289	biological_process	protein homotetramerization
E	0051607	biological_process	defense response to virus
E	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
E	0097197	cellular_component	tetraspanin-enriched microdomain
E	0106375	molecular_function	deoxynucleoside triphosphate hydrolase activity
E	0110025	biological_process	DNA strand resection involved in replication fork processing
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0003676	molecular_function	nucleic acid binding
F	0003697	molecular_function	single-stranded DNA binding
F	0003723	molecular_function	RNA binding
F	0004540	molecular_function	RNA nuclease activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005886	cellular_component	plasma membrane
F	0006203	biological_process	dGTP catabolic process
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006955	biological_process	immune response
F	0006974	biological_process	DNA damage response
F	0008270	molecular_function	zinc ion binding
F	0008832	molecular_function	dGTPase activity
F	0009264	biological_process	deoxyribonucleotide catabolic process
F	0016446	biological_process	somatic hypermutation of immunoglobulin genes
F	0016787	molecular_function	hydrolase activity
F	0016793	molecular_function	triphosphoric monoester hydrolase activity
F	0032567	molecular_function	dGTP binding
F	0035861	cellular_component	site of double-strand break
F	0042802	molecular_function	identical protein binding
F	0045087	biological_process	innate immune response
F	0045088	biological_process	regulation of innate immune response
F	0046061	biological_process	dATP catabolic process
F	0046872	molecular_function	metal ion binding
F	0051289	biological_process	protein homotetramerization
F	0051607	biological_process	defense response to virus
F	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
F	0097197	cellular_component	tetraspanin-enriched microdomain
F	0106375	molecular_function	deoxynucleoside triphosphate hydrolase activity
F	0110025	biological_process	DNA strand resection involved in replication fork processing

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:22056990

Chain	Residue	Details
A	HIS233
B	HIS233
E	HIS233
F	HIS233

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: in chain B => ECO:0000269|PubMed:25267621, ECO:0007744|PDB:4TNP, ECO:0007744|PDB:4TNQ, ECO:0007744|PDB:4TNR, ECO:0007744|PDB:4TNX

Chain	Residue	Details
A	LYS116
B	ARG145
E	LYS116
E	VAL117
E	ASP137
E	GLN142
E	ARG145
F	LYS116
F	VAL117
F	ASP137
F	GLN142
A	VAL117
F	ARG145
A	ASP137
A	GLN142
A	ARG145
B	LYS116
B	VAL117
B	ASP137
B	GLN142

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: in chain B => ECO:0000269|PubMed:25267621, ECO:0007744|PDB:4TNQ

Chain	Residue	Details
A	ASN119
B	ASN119
E	ASN119
F	ASN119

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:25267621, ECO:0007744|PDB:4TNQ

Chain	Residue	Details
A	GLN149
B	ARG164
B	HIS210
B	HIS215
B	LYS312
B	TYR315
B	ASP319
B	GLN375
E	GLN149
E	ARG164
E	HIS210
A	ARG164
E	HIS215
E	LYS312
E	TYR315
E	ASP319
E	GLN375
F	GLN149
F	ARG164
F	HIS210
F	HIS215
F	LYS312
A	HIS210
F	TYR315
F	ASP319
F	GLN375
A	HIS215
A	LYS312
A	TYR315
A	ASP319
A	GLN375
B	GLN149

---

site_id	SWS_FT_FI5
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0007744|PDB:4BZB

Chain	Residue	Details
A	LEU150
B	HIS206
B	ASP207
B	ASP311
B	ARG366
B	TYR374
E	LEU150
E	HIS167
E	HIS206
E	ASP207
E	ASP311
A	HIS167
E	ARG366
E	TYR374
F	LEU150
F	HIS167
F	HIS206
F	ASP207
F	ASP311
F	ARG366
F	TYR374
A	HIS206
A	ASP207
A	ASP311
A	ARG366
A	TYR374
B	LEU150
B	HIS167

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	BINDING: in chain C => ECO:0000269|PubMed:25267621, ECO:0007744|PDB:4TNQ

Chain	Residue	Details
A	VAL156
E	ARG372
E	HIS376
E	LYS377
F	VAL156
F	ARG372
F	HIS376
F	LYS377
A	ARG372
A	HIS376
A	LYS377
B	VAL156
B	ARG372
B	HIS376
B	LYS377
E	VAL156

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: in chain A => ECO:0000269|PubMed:25267621, ECO:0007744|PDB:4TNQ

Chain	Residue	Details
A	ARG333
F	ARG333
F	ARG352
F	LYS354
A	ARG352
A	LYS354
B	ARG333
B	ARG352
B	LYS354
E	ARG333
E	ARG352
E	LYS354

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: in chain A => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:25267621, ECO:0007744|PDB:4BZB, ECO:0007744|PDB:4TNX

Chain	Residue	Details
A	ASN358
B	ASN358
E	ASN358
F	ASN358

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	BINDING: in chain C => ECO:0000269|PubMed:25267621, ECO:0007744|PDB:4TNP, ECO:0007744|PDB:4TNQ, ECO:0007744|PDB:4TNR, ECO:0007744|PDB:4TNX

Chain	Residue	Details
A	ARG451
A	LYS455
B	ARG451
B	LYS455
E	ARG451
E	LYS455
F	ARG451
F	LYS455

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: in chain A => ECO:0000269|PubMed:25267621, ECO:0007744|PDB:4TNP, ECO:0007744|PDB:4TNQ, ECO:0007744|PDB:4TNR, ECO:0007744|PDB:4TNX

Chain	Residue	Details
A	LYS523
B	LYS523
E	LYS523
F	LYS523

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:19413330, ECO:0000269|Ref.8

Chain	Residue	Details
A	MET1
B	MET1
E	MET1
F	MET1

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q60710

Chain	Residue	Details
A	SER18
B	SER18
E	SER18
F	SER18

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q60710

Chain	Residue	Details
A	THR21
A	THR25
B	THR21
B	THR25
E	THR21
E	THR25
F	THR21
F	THR25

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER33
B	SER33
E	SER33
F	SER33

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER93
B	SER93
E	SER93
F	SER93

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR592
B	THR592
E	THR592
F	THR592

---

site_id	SWS_FT_FI17
Number of Residues	20
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS467
B	LYS622
E	LYS467
E	LYS469
E	LYS492
E	LYS622
F	LYS467
F	LYS469
F	LYS492
F	LYS622
A	LYS469
A	LYS492
A	LYS622
B	LYS467
B	LYS469
B	LYS492

---