8TDW

ssRNA bound SAMHD1 T open

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0002376	biological_process	immune system process
A	0003676	molecular_function	nucleic acid binding
A	0003697	molecular_function	single-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004540	molecular_function	RNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006203	biological_process	dGTP catabolic process
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006955	biological_process	immune response
A	0006974	biological_process	DNA damage response
A	0008270	molecular_function	zinc ion binding
A	0008832	molecular_function	dGTPase activity
A	0009264	biological_process	deoxyribonucleotide catabolic process
A	0016446	biological_process	somatic hypermutation of immunoglobulin genes
A	0016787	molecular_function	hydrolase activity
A	0016793	molecular_function	triphosphoric monoester hydrolase activity
A	0032567	molecular_function	dGTP binding
A	0035861	cellular_component	site of double-strand break
A	0045087	biological_process	innate immune response
A	0045088	biological_process	regulation of innate immune response
A	0046061	biological_process	dATP catabolic process
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0051607	biological_process	defense response to virus
A	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
A	0097197	cellular_component	tetraspanin-enriched microdomain
A	0106375	molecular_function	deoxynucleoside triphosphate hydrolase activity
A	0110025	biological_process	DNA strand resection involved in replication fork processing
B	0000166	molecular_function	nucleotide binding
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0002376	biological_process	immune system process
B	0003676	molecular_function	nucleic acid binding
B	0003697	molecular_function	single-stranded DNA binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0004540	molecular_function	RNA nuclease activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006203	biological_process	dGTP catabolic process
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006955	biological_process	immune response
B	0006974	biological_process	DNA damage response
B	0008270	molecular_function	zinc ion binding
B	0008832	molecular_function	dGTPase activity
B	0009264	biological_process	deoxyribonucleotide catabolic process
B	0016446	biological_process	somatic hypermutation of immunoglobulin genes
B	0016787	molecular_function	hydrolase activity
B	0016793	molecular_function	triphosphoric monoester hydrolase activity
B	0032567	molecular_function	dGTP binding
B	0035861	cellular_component	site of double-strand break
B	0045087	biological_process	innate immune response
B	0045088	biological_process	regulation of innate immune response
B	0046061	biological_process	dATP catabolic process
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0051607	biological_process	defense response to virus
B	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
B	0097197	cellular_component	tetraspanin-enriched microdomain
B	0106375	molecular_function	deoxynucleoside triphosphate hydrolase activity
B	0110025	biological_process	DNA strand resection involved in replication fork processing
E	0000166	molecular_function	nucleotide binding
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0002376	biological_process	immune system process
E	0003676	molecular_function	nucleic acid binding
E	0003697	molecular_function	single-stranded DNA binding
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0004540	molecular_function	RNA nuclease activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006203	biological_process	dGTP catabolic process
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006955	biological_process	immune response
E	0006974	biological_process	DNA damage response
E	0008270	molecular_function	zinc ion binding
E	0008832	molecular_function	dGTPase activity
E	0009264	biological_process	deoxyribonucleotide catabolic process
E	0016446	biological_process	somatic hypermutation of immunoglobulin genes
E	0016787	molecular_function	hydrolase activity
E	0016793	molecular_function	triphosphoric monoester hydrolase activity
E	0032567	molecular_function	dGTP binding
E	0035861	cellular_component	site of double-strand break
E	0045087	biological_process	innate immune response
E	0045088	biological_process	regulation of innate immune response
E	0046061	biological_process	dATP catabolic process
E	0046872	molecular_function	metal ion binding
E	0051289	biological_process	protein homotetramerization
E	0051607	biological_process	defense response to virus
E	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
E	0097197	cellular_component	tetraspanin-enriched microdomain
E	0106375	molecular_function	deoxynucleoside triphosphate hydrolase activity
E	0110025	biological_process	DNA strand resection involved in replication fork processing
F	0000166	molecular_function	nucleotide binding
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0002376	biological_process	immune system process
F	0003676	molecular_function	nucleic acid binding
F	0003697	molecular_function	single-stranded DNA binding
F	0003723	molecular_function	RNA binding
F	0003824	molecular_function	catalytic activity
F	0004540	molecular_function	RNA nuclease activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006203	biological_process	dGTP catabolic process
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006955	biological_process	immune response
F	0006974	biological_process	DNA damage response
F	0008270	molecular_function	zinc ion binding
F	0008832	molecular_function	dGTPase activity
F	0009264	biological_process	deoxyribonucleotide catabolic process
F	0016446	biological_process	somatic hypermutation of immunoglobulin genes
F	0016787	molecular_function	hydrolase activity
F	0016793	molecular_function	triphosphoric monoester hydrolase activity
F	0032567	molecular_function	dGTP binding
F	0035861	cellular_component	site of double-strand break
F	0045087	biological_process	innate immune response
F	0045088	biological_process	regulation of innate immune response
F	0046061	biological_process	dATP catabolic process
F	0046872	molecular_function	metal ion binding
F	0051289	biological_process	protein homotetramerization
F	0051607	biological_process	defense response to virus
F	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
F	0097197	cellular_component	tetraspanin-enriched microdomain
F	0106375	molecular_function	deoxynucleoside triphosphate hydrolase activity
F	0110025	biological_process	DNA strand resection involved in replication fork processing

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	456
Details	Domain: {"description":"HD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"22056990","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Binding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CDK1","evidences":[{"source":"PubMed","id":"23601106","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26294762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26431200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29610582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29670289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---