8TA3

Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005247	molecular_function	voltage-gated chloride channel activity
A	0005254	molecular_function	chloride channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0006911	biological_process	phagocytosis, engulfment
A	0008308	molecular_function	voltage-gated monoatomic anion channel activity
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0017081	molecular_function	chloride channel regulator activity
A	0030322	biological_process	stabilization of membrane potential
A	0030324	biological_process	lung development
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0032347	biological_process	regulation of aldosterone biosynthetic process
A	0032591	cellular_component	dendritic spine membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0034707	cellular_component	chloride channel complex
A	0043194	cellular_component	axon initial segment
A	0043204	cellular_component	perikaryon
A	0043209	cellular_component	myelin sheath
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0055085	biological_process	transmembrane transport
A	0060075	biological_process	regulation of resting membrane potential
A	0071476	biological_process	cellular hypotonic response
A	0072320	molecular_function	volume-sensitive chloride channel activity
A	0097450	cellular_component	astrocyte end-foot
A	0098656	biological_process	monoatomic anion transmembrane transport
A	0098902	biological_process	regulation of membrane depolarization during action potential
A	1902476	biological_process	chloride transmembrane transport
B	0005247	molecular_function	voltage-gated chloride channel activity
B	0005254	molecular_function	chloride channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0006911	biological_process	phagocytosis, engulfment
B	0008308	molecular_function	voltage-gated monoatomic anion channel activity
B	0015108	molecular_function	chloride transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0017081	molecular_function	chloride channel regulator activity
B	0030322	biological_process	stabilization of membrane potential
B	0030324	biological_process	lung development
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0032347	biological_process	regulation of aldosterone biosynthetic process
B	0032591	cellular_component	dendritic spine membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0034707	cellular_component	chloride channel complex
B	0043194	cellular_component	axon initial segment
B	0043204	cellular_component	perikaryon
B	0043209	cellular_component	myelin sheath
B	0048714	biological_process	positive regulation of oligodendrocyte differentiation
B	0055085	biological_process	transmembrane transport
B	0060075	biological_process	regulation of resting membrane potential
B	0071476	biological_process	cellular hypotonic response
B	0072320	molecular_function	volume-sensitive chloride channel activity
B	0097450	cellular_component	astrocyte end-foot
B	0098656	biological_process	monoatomic anion transmembrane transport
B	0098902	biological_process	regulation of membrane depolarization during action potential
B	1902476	biological_process	chloride transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	442
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Intramembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	90
Details	Intramembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Intramembrane: {"description":"Note=Loop between two helices","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Motif: {"description":"Selectivity filter part_1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"Selectivity filter part_2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Motif: {"description":"Selectivity filter part_3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Protopore gate","evidences":[{"source":"PubMed","id":"38345841","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Couples extracellular acidification to the channel closure","evidences":[{"source":"UniProtKB","id":"Q9WU45","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9R0A1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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