Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8T9G

Automethylated PRC2 dimer bound to nucleosome

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0001222	molecular_function	transcription corepressor binding
F	0003682	molecular_function	chromatin binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005829	cellular_component	cytosol
F	0006325	biological_process	chromatin organization
F	0008047	molecular_function	enzyme activator activity
F	0021510	biological_process	spinal cord development
F	0031491	molecular_function	nucleosome binding
F	0031507	biological_process	heterochromatin formation
F	0035098	cellular_component	ESC/E(Z) complex
F	0042802	molecular_function	identical protein binding
F	0045892	biological_process	negative regulation of DNA-templated transcription
J	0000786	cellular_component	nucleosome
J	0003677	molecular_function	DNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005694	cellular_component	chromosome
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0001222	molecular_function	transcription corepressor binding
K	0003682	molecular_function	chromatin binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005829	cellular_component	cytosol
K	0006325	biological_process	chromatin organization
K	0008047	molecular_function	enzyme activator activity
K	0021510	biological_process	spinal cord development
K	0031491	molecular_function	nucleosome binding
K	0031507	biological_process	heterochromatin formation
K	0035098	cellular_component	ESC/E(Z) complex
K	0042802	molecular_function	identical protein binding
K	0045892	biological_process	negative regulation of DNA-templated transcription
L	0000118	cellular_component	histone deacetylase complex
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000781	cellular_component	chromosome, telomeric region
L	0000785	cellular_component	chromatin
L	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005829	cellular_component	cytosol
L	0006260	biological_process	DNA replication
L	0006325	biological_process	chromatin organization
L	0006334	biological_process	nucleosome assembly
L	0006335	biological_process	DNA replication-dependent chromatin assembly
L	0006338	biological_process	chromatin remodeling
L	0006355	biological_process	regulation of DNA-templated transcription
L	0007420	biological_process	brain development
L	0008094	molecular_function	ATP-dependent activity, acting on DNA
L	0008285	biological_process	negative regulation of cell population proliferation
L	0016581	cellular_component	NuRD complex
L	0016589	cellular_component	NURF complex
L	0030336	biological_process	negative regulation of cell migration
L	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
L	0031492	molecular_function	nucleosomal DNA binding
L	0032991	cellular_component	protein-containing complex
L	0033186	cellular_component	CAF-1 complex
L	0035098	cellular_component	ESC/E(Z) complex
L	0042393	molecular_function	histone binding
L	0042659	biological_process	regulation of cell fate specification
L	0042826	molecular_function	histone deacetylase binding
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0070822	cellular_component	Sin3-type complex
L	1902455	biological_process	negative regulation of stem cell population maintenance
L	1902459	biological_process	positive regulation of stem cell population maintenance
L	1904949	cellular_component	ATPase complex
L	2000736	biological_process	regulation of stem cell differentiation
O	0000118	cellular_component	histone deacetylase complex
O	0000122	biological_process	negative regulation of transcription by RNA polymerase II
O	0000781	cellular_component	chromosome, telomeric region
O	0000785	cellular_component	chromatin
O	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005829	cellular_component	cytosol
O	0006260	biological_process	DNA replication
O	0006325	biological_process	chromatin organization
O	0006334	biological_process	nucleosome assembly
O	0006335	biological_process	DNA replication-dependent chromatin assembly
O	0006338	biological_process	chromatin remodeling
O	0006355	biological_process	regulation of DNA-templated transcription
O	0007420	biological_process	brain development
O	0008094	molecular_function	ATP-dependent activity, acting on DNA
O	0008285	biological_process	negative regulation of cell population proliferation
O	0016581	cellular_component	NuRD complex
O	0016589	cellular_component	NURF complex
O	0030336	biological_process	negative regulation of cell migration
O	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
O	0031492	molecular_function	nucleosomal DNA binding
O	0032991	cellular_component	protein-containing complex
O	0033186	cellular_component	CAF-1 complex
O	0035098	cellular_component	ESC/E(Z) complex
O	0042393	molecular_function	histone binding
O	0042659	biological_process	regulation of cell fate specification
O	0042826	molecular_function	histone deacetylase binding
O	0045892	biological_process	negative regulation of DNA-templated transcription
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0070822	cellular_component	Sin3-type complex
O	1902455	biological_process	negative regulation of stem cell population maintenance
O	1902459	biological_process	positive regulation of stem cell population maintenance
O	1904949	cellular_component	ATPase complex
O	2000736	biological_process	regulation of stem cell differentiation
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0005634	cellular_component	nucleus
R	0005694	cellular_component	chromosome
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005694	cellular_component	chromosome
U	0000786	cellular_component	nucleosome
U	0003677	molecular_function	DNA binding
U	0005634	cellular_component	nucleus
U	0005694	cellular_component	chromosome
V	0000786	cellular_component	nucleosome
V	0003677	molecular_function	DNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005694	cellular_component	chromosome
W	0000786	cellular_component	nucleosome
W	0003677	molecular_function	DNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005694	cellular_component	chromosome
X	0000786	cellular_component	nucleosome
X	0003677	molecular_function	DNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005694	cellular_component	chromosome

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	24
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CcwdqCqacFnsspdladHirsi.H

Chain	Residue	Details
M	CYS55-HIS78
M	CYS122-HIS144
B	CYS450-HIS471

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
R	ALA21-VAL27

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
J	GLY14-HIS18

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
S	ARG89-GLY111

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI

Chain	Residue	Details
F	LEU206-ILE220
L	LEU193-ILE207
L	LEU289-LEU303
L	LEU333-LEU347

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.9, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
L	ALA2
O	ALA2
S	LYS12
S	LYS17
V	LYS2
V	LYS9
V	LYS12
V	LYS17

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
L	LYS4
O	LYS4
I	SER76
I	SER368

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
L	SER110
O	SER110
U	LYS9
U	LYS95

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250\|UniProtKB:Q60972

Chain	Residue	Details
L	LYS160
O	LYS160
F	LYS268
F	LYS284
K	LYS66
K	LYS197
K	LYS268
K	LYS284

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
L	SER355
O	SER355
U	LYS74
U	LYS75
X	LYS8
X	LYS16
X	LYS44
X	LYS79

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
L	LYS4
O	LYS4
G	LYS72
G	LYS73

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:25755297, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
C	THR492
L	LYS160
B	LYS390
O	LYS160
G	LYS223
G	LYS390

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269\|PubMed:24474760

Chain	Residue	Details
C	SER75
I	SER75
R	LYS15
R	CYS119
U	LYS13
U	LYS15
U	CYS119

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
C	LYS639
J	TYR88
I	LYS639
X	TYR88

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
J	LYS59
W	LYS64
X	LYS59
A	LYS27
A	LYS36
A	LYS64
W	LYS18
W	LYS23
W	LYS27
W	LYS36

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
J	LYS77
X	LYS77

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
J	LYS31
X	LYS31

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P62805

Chain	Residue	Details
A	LYS37
J	LYS91
X	LYS91

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	TYR41
W	TYR41

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P84228

Chain	Residue	Details
A	LYS56
A	LYS79
W	LYS56
W	LYS79

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	SER57
W	SER57

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	THR80
A	THR107
W	THR80
W	THR107

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	SER86
W	SER86

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS115
W	LYS115

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	LYS122
W	LYS122

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250\|UniProtKB:Q71DI3

Chain	Residue	Details
A	CYS110
W	CYS110

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)