8T31

Crystal structure of GABARAP in complex with the LIR of TP53INP2/DOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000139	cellular_component	Golgi membrane
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000421	cellular_component	autophagosome membrane
A	0000422	biological_process	autophagy of mitochondrion
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005875	cellular_component	microtubule associated complex
A	0005886	cellular_component	plasma membrane
A	0005930	cellular_component	axoneme
A	0006605	biological_process	protein targeting
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006995	biological_process	cellular response to nitrogen starvation
A	0007268	biological_process	chemical synaptic transmission
A	0008017	molecular_function	microtubule binding
A	0008429	molecular_function	phosphatidylethanolamine binding
A	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
A	0012505	cellular_component	endomembrane system
A	0015031	biological_process	protein transport
A	0015629	cellular_component	actin cytoskeleton
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0035020	biological_process	regulation of Rac protein signal transduction
A	0045202	cellular_component	synapse
A	0048487	molecular_function	beta-tubulin binding
A	0050811	molecular_function	GABA receptor binding
A	0097225	cellular_component	sperm midpiece
A	0097352	biological_process	autophagosome maturation
A	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
C	0000045	biological_process	autophagosome assembly
C	0000139	cellular_component	Golgi membrane
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000421	cellular_component	autophagosome membrane
C	0000422	biological_process	autophagy of mitochondrion
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0005790	cellular_component	smooth endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005875	cellular_component	microtubule associated complex
C	0005886	cellular_component	plasma membrane
C	0005930	cellular_component	axoneme
C	0006605	biological_process	protein targeting
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006995	biological_process	cellular response to nitrogen starvation
C	0007268	biological_process	chemical synaptic transmission
C	0008017	molecular_function	microtubule binding
C	0008429	molecular_function	phosphatidylethanolamine binding
C	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
C	0012505	cellular_component	endomembrane system
C	0015031	biological_process	protein transport
C	0015629	cellular_component	actin cytoskeleton
C	0016020	cellular_component	membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0035020	biological_process	regulation of Rac protein signal transduction
C	0045202	cellular_component	synapse
C	0048487	molecular_function	beta-tubulin binding
C	0050811	molecular_function	GABA receptor binding
C	0097225	cellular_component	sperm midpiece
C	0097352	biological_process	autophagosome maturation
C	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
E	0000045	biological_process	autophagosome assembly
E	0000139	cellular_component	Golgi membrane
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000421	cellular_component	autophagosome membrane
E	0000422	biological_process	autophagy of mitochondrion
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005776	cellular_component	autophagosome
E	0005790	cellular_component	smooth endoplasmic reticulum
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005875	cellular_component	microtubule associated complex
E	0005886	cellular_component	plasma membrane
E	0005930	cellular_component	axoneme
E	0006605	biological_process	protein targeting
E	0006914	biological_process	autophagy
E	0006915	biological_process	apoptotic process
E	0006995	biological_process	cellular response to nitrogen starvation
E	0007268	biological_process	chemical synaptic transmission
E	0008017	molecular_function	microtubule binding
E	0008429	molecular_function	phosphatidylethanolamine binding
E	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
E	0012505	cellular_component	endomembrane system
E	0015031	biological_process	protein transport
E	0015629	cellular_component	actin cytoskeleton
E	0016020	cellular_component	membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0035020	biological_process	regulation of Rac protein signal transduction
E	0045202	cellular_component	synapse
E	0048487	molecular_function	beta-tubulin binding
E	0050811	molecular_function	GABA receptor binding
E	0097225	cellular_component	sperm midpiece
E	0097352	biological_process	autophagosome maturation
E	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
G	0000045	biological_process	autophagosome assembly
G	0000139	cellular_component	Golgi membrane
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000421	cellular_component	autophagosome membrane
G	0000422	biological_process	autophagy of mitochondrion
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005776	cellular_component	autophagosome
G	0005790	cellular_component	smooth endoplasmic reticulum
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005875	cellular_component	microtubule associated complex
G	0005886	cellular_component	plasma membrane
G	0005930	cellular_component	axoneme
G	0006605	biological_process	protein targeting
G	0006914	biological_process	autophagy
G	0006915	biological_process	apoptotic process
G	0006995	biological_process	cellular response to nitrogen starvation
G	0007268	biological_process	chemical synaptic transmission
G	0008017	molecular_function	microtubule binding
G	0008429	molecular_function	phosphatidylethanolamine binding
G	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
G	0012505	cellular_component	endomembrane system
G	0015031	biological_process	protein transport
G	0015629	cellular_component	actin cytoskeleton
G	0016020	cellular_component	membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0035020	biological_process	regulation of Rac protein signal transduction
G	0045202	cellular_component	synapse
G	0048487	molecular_function	beta-tubulin binding
G	0050811	molecular_function	GABA receptor binding
G	0097225	cellular_component	sperm midpiece
G	0097352	biological_process	autophagosome maturation
G	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
I	0000045	biological_process	autophagosome assembly
I	0000139	cellular_component	Golgi membrane
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000421	cellular_component	autophagosome membrane
I	0000422	biological_process	autophagy of mitochondrion
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005776	cellular_component	autophagosome
I	0005790	cellular_component	smooth endoplasmic reticulum
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0005875	cellular_component	microtubule associated complex
I	0005886	cellular_component	plasma membrane
I	0005930	cellular_component	axoneme
I	0006605	biological_process	protein targeting
I	0006914	biological_process	autophagy
I	0006915	biological_process	apoptotic process
I	0006995	biological_process	cellular response to nitrogen starvation
I	0007268	biological_process	chemical synaptic transmission
I	0008017	molecular_function	microtubule binding
I	0008429	molecular_function	phosphatidylethanolamine binding
I	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
I	0012505	cellular_component	endomembrane system
I	0015031	biological_process	protein transport
I	0015629	cellular_component	actin cytoskeleton
I	0016020	cellular_component	membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
I	0035020	biological_process	regulation of Rac protein signal transduction
I	0045202	cellular_component	synapse
I	0048487	molecular_function	beta-tubulin binding
I	0050811	molecular_function	GABA receptor binding
I	0097225	cellular_component	sperm midpiece
I	0097352	biological_process	autophagosome maturation
I	1902524	biological_process	positive regulation of protein K48-linked ubiquitination

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	SITE: Interaction with LIR (LC3 nteracting Region) motif of ATG3 => ECO:0000269|PubMed:37252361, ECO:0007744|PDB:8AFI

Chain	Residue	Details
A	GLU17
I	ARG28
A	ARG28
C	GLU17
C	ARG28
E	GLU17
E	ARG28
G	GLU17
G	ARG28
I	GLU17

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	SITE: Cleavage; by ATG4B => ECO:0000269|PubMed:15169837

Chain	Residue	Details
A	GLY116
C	GLY116
E	GLY116
G	GLY116
I	GLY116

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	LIPID: Phosphatidylserine amidated glycine; alternate => ECO:0000269|PubMed:33909989

Chain	Residue	Details
A	GLY116
C	GLY116
E	GLY116
G	GLY116
I	GLY116

---