Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8SZA

Cryo-EM Structure of NINJ1 Filament at 2.75 Angstrom Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001530	molecular_function	lipopolysaccharide binding
A	0002232	biological_process	leukocyte chemotaxis involved in inflammatory response
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0006954	biological_process	inflammatory response
A	0007155	biological_process	cell adhesion
A	0007399	biological_process	nervous system development
A	0016020	cellular_component	membrane
A	0019835	biological_process	cytolysis
A	0031640	biological_process	killing of cells of another organism
A	0034113	biological_process	heterotypic cell-cell adhesion
A	0034145	biological_process	positive regulation of toll-like receptor 4 signaling pathway
A	0042246	biological_process	tissue regeneration
A	0042692	biological_process	muscle cell differentiation
A	0045766	biological_process	positive regulation of angiogenesis
A	0050729	biological_process	positive regulation of inflammatory response
A	0051260	biological_process	protein homooligomerization
A	0071474	biological_process	cellular hyperosmotic response
A	0097060	cellular_component	synaptic membrane
A	0097300	biological_process	programmed necrotic cell death
A	0097707	biological_process	ferroptosis
A	0098631	molecular_function	cell adhesion mediator activity
A	0140912	molecular_function	membrane destabilizing activity
A	0141201	biological_process	pyroptotic cell death
B	0001525	biological_process	angiogenesis
B	0001530	molecular_function	lipopolysaccharide binding
B	0002232	biological_process	leukocyte chemotaxis involved in inflammatory response
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0006954	biological_process	inflammatory response
B	0007155	biological_process	cell adhesion
B	0007399	biological_process	nervous system development
B	0016020	cellular_component	membrane
B	0019835	biological_process	cytolysis
B	0031640	biological_process	killing of cells of another organism
B	0034113	biological_process	heterotypic cell-cell adhesion
B	0034145	biological_process	positive regulation of toll-like receptor 4 signaling pathway
B	0042246	biological_process	tissue regeneration
B	0042692	biological_process	muscle cell differentiation
B	0045766	biological_process	positive regulation of angiogenesis
B	0050729	biological_process	positive regulation of inflammatory response
B	0051260	biological_process	protein homooligomerization
B	0071474	biological_process	cellular hyperosmotic response
B	0097060	cellular_component	synaptic membrane
B	0097300	biological_process	programmed necrotic cell death
B	0097707	biological_process	ferroptosis
B	0098631	molecular_function	cell adhesion mediator activity
B	0140912	molecular_function	membrane destabilizing activity
B	0141201	biological_process	pyroptotic cell death
C	0001525	biological_process	angiogenesis
C	0001530	molecular_function	lipopolysaccharide binding
C	0002232	biological_process	leukocyte chemotaxis involved in inflammatory response
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0006954	biological_process	inflammatory response
C	0007155	biological_process	cell adhesion
C	0007399	biological_process	nervous system development
C	0016020	cellular_component	membrane
C	0019835	biological_process	cytolysis
C	0031640	biological_process	killing of cells of another organism
C	0034113	biological_process	heterotypic cell-cell adhesion
C	0034145	biological_process	positive regulation of toll-like receptor 4 signaling pathway
C	0042246	biological_process	tissue regeneration
C	0042692	biological_process	muscle cell differentiation
C	0045766	biological_process	positive regulation of angiogenesis
C	0050729	biological_process	positive regulation of inflammatory response
C	0051260	biological_process	protein homooligomerization
C	0071474	biological_process	cellular hyperosmotic response
C	0097060	cellular_component	synaptic membrane
C	0097300	biological_process	programmed necrotic cell death
C	0097707	biological_process	ferroptosis
C	0098631	molecular_function	cell adhesion mediator activity
C	0140912	molecular_function	membrane destabilizing activity
C	0141201	biological_process	pyroptotic cell death
D	0001525	biological_process	angiogenesis
D	0001530	molecular_function	lipopolysaccharide binding
D	0002232	biological_process	leukocyte chemotaxis involved in inflammatory response
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0006954	biological_process	inflammatory response
D	0007155	biological_process	cell adhesion
D	0007399	biological_process	nervous system development
D	0016020	cellular_component	membrane
D	0019835	biological_process	cytolysis
D	0031640	biological_process	killing of cells of another organism
D	0034113	biological_process	heterotypic cell-cell adhesion
D	0034145	biological_process	positive regulation of toll-like receptor 4 signaling pathway
D	0042246	biological_process	tissue regeneration
D	0042692	biological_process	muscle cell differentiation
D	0045766	biological_process	positive regulation of angiogenesis
D	0050729	biological_process	positive regulation of inflammatory response
D	0051260	biological_process	protein homooligomerization
D	0071474	biological_process	cellular hyperosmotic response
D	0097060	cellular_component	synaptic membrane
D	0097300	biological_process	programmed necrotic cell death
D	0097707	biological_process	ferroptosis
D	0098631	molecular_function	cell adhesion mediator activity
D	0140912	molecular_function	membrane destabilizing activity
D	0141201	biological_process	pyroptotic cell death
E	0001525	biological_process	angiogenesis
E	0001530	molecular_function	lipopolysaccharide binding
E	0002232	biological_process	leukocyte chemotaxis involved in inflammatory response
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005886	cellular_component	plasma membrane
E	0006954	biological_process	inflammatory response
E	0007155	biological_process	cell adhesion
E	0007399	biological_process	nervous system development
E	0016020	cellular_component	membrane
E	0019835	biological_process	cytolysis
E	0031640	biological_process	killing of cells of another organism
E	0034113	biological_process	heterotypic cell-cell adhesion
E	0034145	biological_process	positive regulation of toll-like receptor 4 signaling pathway
E	0042246	biological_process	tissue regeneration
E	0042692	biological_process	muscle cell differentiation
E	0045766	biological_process	positive regulation of angiogenesis
E	0050729	biological_process	positive regulation of inflammatory response
E	0051260	biological_process	protein homooligomerization
E	0071474	biological_process	cellular hyperosmotic response
E	0097060	cellular_component	synaptic membrane
E	0097300	biological_process	programmed necrotic cell death
E	0097707	biological_process	ferroptosis
E	0098631	molecular_function	cell adhesion mediator activity
E	0140912	molecular_function	membrane destabilizing activity
E	0141201	biological_process	pyroptotic cell death
F	0001525	biological_process	angiogenesis
F	0001530	molecular_function	lipopolysaccharide binding
F	0002232	biological_process	leukocyte chemotaxis involved in inflammatory response
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005886	cellular_component	plasma membrane
F	0006954	biological_process	inflammatory response
F	0007155	biological_process	cell adhesion
F	0007399	biological_process	nervous system development
F	0016020	cellular_component	membrane
F	0019835	biological_process	cytolysis
F	0031640	biological_process	killing of cells of another organism
F	0034113	biological_process	heterotypic cell-cell adhesion
F	0034145	biological_process	positive regulation of toll-like receptor 4 signaling pathway
F	0042246	biological_process	tissue regeneration
F	0042692	biological_process	muscle cell differentiation
F	0045766	biological_process	positive regulation of angiogenesis
F	0050729	biological_process	positive regulation of inflammatory response
F	0051260	biological_process	protein homooligomerization
F	0071474	biological_process	cellular hyperosmotic response
F	0097060	cellular_component	synaptic membrane
F	0097300	biological_process	programmed necrotic cell death
F	0097707	biological_process	ferroptosis
F	0098631	molecular_function	cell adhesion mediator activity
F	0140912	molecular_function	membrane destabilizing activity
F	0141201	biological_process	pyroptotic cell death

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=Helix alpha3","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	54
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=Helix alpha4","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	174
Details	Region: {"description":"Required to induce plasma membrane rupture","evidences":[{"source":"UniProtKB","id":"O70131","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	66
Details	Region: {"description":"Helix alpha1","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	96
Details	Region: {"description":"Helix alpha2","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Site: {"description":"Cleavage; by MMP9","evidences":[{"source":"UniProtKB","id":"O70131","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)