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8SZA

Cryo-EM Structure of NINJ1 Filament at 2.75 Angstrom Resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001530molecular_functionlipopolysaccharide binding
A0002232biological_processleukocyte chemotaxis involved in inflammatory response
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006954biological_processinflammatory response
A0007155biological_processcell adhesion
A0007399biological_processnervous system development
A0016020cellular_componentmembrane
A0019835biological_processcytolysis
A0031640biological_processkilling of cells of another organism
A0034113biological_processheterotypic cell-cell adhesion
A0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
A0042246biological_processtissue regeneration
A0042692biological_processmuscle cell differentiation
A0045202cellular_componentsynapse
A0045766biological_processpositive regulation of angiogenesis
A0050729biological_processpositive regulation of inflammatory response
A0051260biological_processprotein homooligomerization
A0071474biological_processcellular hyperosmotic response
A0097060cellular_componentsynaptic membrane
A0097300biological_processprogrammed necrotic cell death
A0097707biological_processferroptosis
A0098631molecular_functioncell adhesion mediator activity
A0140912molecular_functionmembrane destabilizing activity
A0141201biological_processpyroptotic cell death
B0001525biological_processangiogenesis
B0001530molecular_functionlipopolysaccharide binding
B0002232biological_processleukocyte chemotaxis involved in inflammatory response
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0006954biological_processinflammatory response
B0007155biological_processcell adhesion
B0007399biological_processnervous system development
B0016020cellular_componentmembrane
B0019835biological_processcytolysis
B0031640biological_processkilling of cells of another organism
B0034113biological_processheterotypic cell-cell adhesion
B0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
B0042246biological_processtissue regeneration
B0042692biological_processmuscle cell differentiation
B0045202cellular_componentsynapse
B0045766biological_processpositive regulation of angiogenesis
B0050729biological_processpositive regulation of inflammatory response
B0051260biological_processprotein homooligomerization
B0071474biological_processcellular hyperosmotic response
B0097060cellular_componentsynaptic membrane
B0097300biological_processprogrammed necrotic cell death
B0097707biological_processferroptosis
B0098631molecular_functioncell adhesion mediator activity
B0140912molecular_functionmembrane destabilizing activity
B0141201biological_processpyroptotic cell death
C0001525biological_processangiogenesis
C0001530molecular_functionlipopolysaccharide binding
C0002232biological_processleukocyte chemotaxis involved in inflammatory response
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0006954biological_processinflammatory response
C0007155biological_processcell adhesion
C0007399biological_processnervous system development
C0016020cellular_componentmembrane
C0019835biological_processcytolysis
C0031640biological_processkilling of cells of another organism
C0034113biological_processheterotypic cell-cell adhesion
C0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
C0042246biological_processtissue regeneration
C0042692biological_processmuscle cell differentiation
C0045202cellular_componentsynapse
C0045766biological_processpositive regulation of angiogenesis
C0050729biological_processpositive regulation of inflammatory response
C0051260biological_processprotein homooligomerization
C0071474biological_processcellular hyperosmotic response
C0097060cellular_componentsynaptic membrane
C0097300biological_processprogrammed necrotic cell death
C0097707biological_processferroptosis
C0098631molecular_functioncell adhesion mediator activity
C0140912molecular_functionmembrane destabilizing activity
C0141201biological_processpyroptotic cell death
D0001525biological_processangiogenesis
D0001530molecular_functionlipopolysaccharide binding
D0002232biological_processleukocyte chemotaxis involved in inflammatory response
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005886cellular_componentplasma membrane
D0006954biological_processinflammatory response
D0007155biological_processcell adhesion
D0007399biological_processnervous system development
D0016020cellular_componentmembrane
D0019835biological_processcytolysis
D0031640biological_processkilling of cells of another organism
D0034113biological_processheterotypic cell-cell adhesion
D0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
D0042246biological_processtissue regeneration
D0042692biological_processmuscle cell differentiation
D0045202cellular_componentsynapse
D0045766biological_processpositive regulation of angiogenesis
D0050729biological_processpositive regulation of inflammatory response
D0051260biological_processprotein homooligomerization
D0071474biological_processcellular hyperosmotic response
D0097060cellular_componentsynaptic membrane
D0097300biological_processprogrammed necrotic cell death
D0097707biological_processferroptosis
D0098631molecular_functioncell adhesion mediator activity
D0140912molecular_functionmembrane destabilizing activity
D0141201biological_processpyroptotic cell death
E0001525biological_processangiogenesis
E0001530molecular_functionlipopolysaccharide binding
E0002232biological_processleukocyte chemotaxis involved in inflammatory response
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005886cellular_componentplasma membrane
E0006954biological_processinflammatory response
E0007155biological_processcell adhesion
E0007399biological_processnervous system development
E0016020cellular_componentmembrane
E0019835biological_processcytolysis
E0031640biological_processkilling of cells of another organism
E0034113biological_processheterotypic cell-cell adhesion
E0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
E0042246biological_processtissue regeneration
E0042692biological_processmuscle cell differentiation
E0045202cellular_componentsynapse
E0045766biological_processpositive regulation of angiogenesis
E0050729biological_processpositive regulation of inflammatory response
E0051260biological_processprotein homooligomerization
E0071474biological_processcellular hyperosmotic response
E0097060cellular_componentsynaptic membrane
E0097300biological_processprogrammed necrotic cell death
E0097707biological_processferroptosis
E0098631molecular_functioncell adhesion mediator activity
E0140912molecular_functionmembrane destabilizing activity
E0141201biological_processpyroptotic cell death
F0001525biological_processangiogenesis
F0001530molecular_functionlipopolysaccharide binding
F0002232biological_processleukocyte chemotaxis involved in inflammatory response
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005886cellular_componentplasma membrane
F0006954biological_processinflammatory response
F0007155biological_processcell adhesion
F0007399biological_processnervous system development
F0016020cellular_componentmembrane
F0019835biological_processcytolysis
F0031640biological_processkilling of cells of another organism
F0034113biological_processheterotypic cell-cell adhesion
F0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
F0042246biological_processtissue regeneration
F0042692biological_processmuscle cell differentiation
F0045202cellular_componentsynapse
F0045766biological_processpositive regulation of angiogenesis
F0050729biological_processpositive regulation of inflammatory response
F0051260biological_processprotein homooligomerization
F0071474biological_processcellular hyperosmotic response
F0097060cellular_componentsynaptic membrane
F0097300biological_processprogrammed necrotic cell death
F0097707biological_processferroptosis
F0098631molecular_functioncell adhesion mediator activity
F0140912molecular_functionmembrane destabilizing activity
F0141201biological_processpyroptotic cell death
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues144
DetailsTRANSMEM: Helical; Name=Helix alpha3 => ECO:0000269|PubMed:37198476, ECO:0007744|PDB:8CQR
ChainResidueDetails
APRO79-LYS103
BPRO79-LYS103
CPRO79-LYS103
DPRO79-LYS103
EPRO79-LYS103
FPRO79-LYS103

site_idSWS_FT_FI2
Number of Residues54
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:37198476, ECO:0007744|PDB:8CQR
ChainResidueDetails
ATYR104-ALA113
BTYR104-ALA113
CTYR104-ALA113
DTYR104-ALA113
ETYR104-ALA113
FTYR104-ALA113

site_idSWS_FT_FI3
Number of Residues144
DetailsTRANSMEM: Helical;Name=Helix alpha4 => ECO:0000269|PubMed:37198476, ECO:0007744|PDB:8CQR
ChainResidueDetails
ALYS114-ALA138
BLYS114-ALA138
CLYS114-ALA138
DLYS114-ALA138
ELYS114-ALA138
FLYS114-ALA138

site_idSWS_FT_FI4
Number of Residues78
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:37198476, ECO:0007744|PDB:8CQR
ChainResidueDetails
APHE139-GLN152
BPHE139-GLN152
CPHE139-GLN152
DPHE139-GLN152
EPHE139-GLN152
FPHE139-GLN152

site_idSWS_FT_FI5
Number of Residues6
DetailsSITE: Cleavage; by MMP9 => ECO:0000250|UniProtKB:O70131
ChainResidueDetails
ALEU56
BLEU56
CLEU56
DLEU56
ELEU56
FLEU56

site_idSWS_FT_FI6
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70617
ChainResidueDetails
ASER21
ESER25
FSER21
FSER25
ASER25
BSER21
BSER25
CSER21
CSER25
DSER21
DSER25
ESER21

site_idSWS_FT_FI7
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AASN60
BASN60
CASN60
DASN60
EASN60
FASN60

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PDB entries from 2024-07-17

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