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8ST0

The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0001666biological_processresponse to hypoxia
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005892cellular_componentacetylcholine-gated channel complex
A0006281biological_processDNA repair
A0006338biological_processchromatin remodeling
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006979biological_processresponse to oxidative stress
A0007165biological_processsignal transduction
A0007268biological_processchemical synaptic transmission
A0007271biological_processsynaptic transmission, cholinergic
A0007274biological_processneuromuscular synaptic transmission
A0009897cellular_componentexternal side of plasma membrane
A0014059biological_processregulation of dopamine secretion
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015464molecular_functionacetylcholine receptor activity
A0016020cellular_componentmembrane
A0019233biological_processsensory perception of pain
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0030425cellular_componentdendrite
A0034220biological_processmonoatomic ion transmembrane transport
A0034703cellular_componentcation channel complex
A0035094biological_processresponse to nicotine
A0035095biological_processbehavioral response to nicotine
A0042113biological_processB cell activation
A0042166molecular_functionacetylcholine binding
A0042391biological_processregulation of membrane potential
A0042734cellular_componentpresynaptic membrane
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0050877biological_processnervous system process
A0050890biological_processcognition
A0051899biological_processmembrane depolarization
A0060079biological_processexcitatory postsynaptic potential
A0060080biological_processinhibitory postsynaptic potential
A0095500biological_processacetylcholine receptor signaling pathway
A0097060cellular_componentsynaptic membrane
A0098878cellular_componentneurotransmitter receptor complex
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0140658molecular_functionATP-dependent chromatin remodeler activity
B0001666biological_processresponse to hypoxia
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005892cellular_componentacetylcholine-gated channel complex
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006939biological_processsmooth muscle contraction
B0007165biological_processsignal transduction
B0007268biological_processchemical synaptic transmission
B0007271biological_processsynaptic transmission, cholinergic
B0007601biological_processvisual perception
B0007605biological_processsensory perception of sound
B0007612biological_processlearning
B0007613biological_processmemory
B0007626biological_processlocomotory behavior
B0008306biological_processassociative learning
B0008542biological_processvisual learning
B0009897cellular_componentexternal side of plasma membrane
B0014059biological_processregulation of dopamine secretion
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0015464molecular_functionacetylcholine receptor activity
B0016020cellular_componentmembrane
B0019233biological_processsensory perception of pain
B0021562biological_processvestibulocochlear nerve development
B0021631biological_processoptic nerve morphogenesis
B0021771biological_processlateral geniculate nucleus development
B0021952biological_processcentral nervous system projection neuron axonogenesis
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0030890biological_processpositive regulation of B cell proliferation
B0032225biological_processregulation of synaptic transmission, dopaminergic
B0033603biological_processpositive regulation of dopamine secretion
B0034220biological_processmonoatomic ion transmembrane transport
B0034703cellular_componentcation channel complex
B0035094biological_processresponse to nicotine
B0035095biological_processbehavioral response to nicotine
B0035176biological_processsocial behavior
B0042053biological_processregulation of dopamine metabolic process
B0042113biological_processB cell activation
B0042166molecular_functionacetylcholine binding
B0042220biological_processresponse to cocaine
B0042320biological_processregulation of circadian sleep/wake cycle, REM sleep
B0043005cellular_componentneuron projection
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045471biological_processresponse to ethanol
B0045759biological_processnegative regulation of action potential
B0048814biological_processregulation of dendrite morphogenesis
B0050877biological_processnervous system process
B0050890biological_processcognition
B0051899biological_processmembrane depolarization
B0051963biological_processregulation of synapse assembly
B0060078biological_processregulation of postsynaptic membrane potential
B0060079biological_processexcitatory postsynaptic potential
B0060084biological_processsynaptic transmission involved in micturition
B0095500biological_processacetylcholine receptor signaling pathway
B0097060cellular_componentsynaptic membrane
B0098878cellular_componentneurotransmitter receptor complex
B1905144biological_processresponse to acetylcholine
C0001666biological_processresponse to hypoxia
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0005892cellular_componentacetylcholine-gated channel complex
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006939biological_processsmooth muscle contraction
C0007165biological_processsignal transduction
C0007268biological_processchemical synaptic transmission
C0007271biological_processsynaptic transmission, cholinergic
C0007601biological_processvisual perception
C0007605biological_processsensory perception of sound
C0007612biological_processlearning
C0007613biological_processmemory
C0007626biological_processlocomotory behavior
C0008306biological_processassociative learning
C0008542biological_processvisual learning
C0009897cellular_componentexternal side of plasma membrane
C0014059biological_processregulation of dopamine secretion
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015464molecular_functionacetylcholine receptor activity
C0016020cellular_componentmembrane
C0019233biological_processsensory perception of pain
C0021562biological_processvestibulocochlear nerve development
C0021631biological_processoptic nerve morphogenesis
C0021771biological_processlateral geniculate nucleus development
C0021952biological_processcentral nervous system projection neuron axonogenesis
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0030890biological_processpositive regulation of B cell proliferation
C0032225biological_processregulation of synaptic transmission, dopaminergic
C0033603biological_processpositive regulation of dopamine secretion
C0034220biological_processmonoatomic ion transmembrane transport
C0034703cellular_componentcation channel complex
C0035094biological_processresponse to nicotine
C0035095biological_processbehavioral response to nicotine
C0035176biological_processsocial behavior
C0042053biological_processregulation of dopamine metabolic process
C0042113biological_processB cell activation
C0042166molecular_functionacetylcholine binding
C0042220biological_processresponse to cocaine
C0042320biological_processregulation of circadian sleep/wake cycle, REM sleep
C0043005cellular_componentneuron projection
C0044853cellular_componentplasma membrane raft
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045471biological_processresponse to ethanol
C0045759biological_processnegative regulation of action potential
C0048814biological_processregulation of dendrite morphogenesis
C0050877biological_processnervous system process
C0050890biological_processcognition
C0051899biological_processmembrane depolarization
C0051963biological_processregulation of synapse assembly
C0060078biological_processregulation of postsynaptic membrane potential
C0060079biological_processexcitatory postsynaptic potential
C0060084biological_processsynaptic transmission involved in micturition
C0095500biological_processacetylcholine receptor signaling pathway
C0097060cellular_componentsynaptic membrane
C0098878cellular_componentneurotransmitter receptor complex
C1905144biological_processresponse to acetylcholine
D0001508biological_processaction potential
D0001666biological_processresponse to hypoxia
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005892cellular_componentacetylcholine-gated channel complex
D0006281biological_processDNA repair
D0006338biological_processchromatin remodeling
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006979biological_processresponse to oxidative stress
D0007165biological_processsignal transduction
D0007268biological_processchemical synaptic transmission
D0007271biological_processsynaptic transmission, cholinergic
D0007274biological_processneuromuscular synaptic transmission
D0009897cellular_componentexternal side of plasma membrane
D0014059biological_processregulation of dopamine secretion
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015464molecular_functionacetylcholine receptor activity
D0016020cellular_componentmembrane
D0019233biological_processsensory perception of pain
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0030425cellular_componentdendrite
D0034220biological_processmonoatomic ion transmembrane transport
D0034703cellular_componentcation channel complex
D0035094biological_processresponse to nicotine
D0035095biological_processbehavioral response to nicotine
D0042113biological_processB cell activation
D0042166molecular_functionacetylcholine binding
D0042391biological_processregulation of membrane potential
D0042734cellular_componentpresynaptic membrane
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0050877biological_processnervous system process
D0050890biological_processcognition
D0051899biological_processmembrane depolarization
D0060079biological_processexcitatory postsynaptic potential
D0060080biological_processinhibitory postsynaptic potential
D0095500biological_processacetylcholine receptor signaling pathway
D0097060cellular_componentsynaptic membrane
D0098878cellular_componentneurotransmitter receptor complex
D0099171biological_processpresynaptic modulation of chemical synaptic transmission
D0140658molecular_functionATP-dependent chromatin remodeler activity
E0001666biological_processresponse to hypoxia
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0005892cellular_componentacetylcholine-gated channel complex
E0006811biological_processmonoatomic ion transport
E0006816biological_processcalcium ion transport
E0006939biological_processsmooth muscle contraction
E0007165biological_processsignal transduction
E0007268biological_processchemical synaptic transmission
E0007271biological_processsynaptic transmission, cholinergic
E0007601biological_processvisual perception
E0007605biological_processsensory perception of sound
E0007612biological_processlearning
E0007613biological_processmemory
E0007626biological_processlocomotory behavior
E0008306biological_processassociative learning
E0008542biological_processvisual learning
E0009897cellular_componentexternal side of plasma membrane
E0014059biological_processregulation of dopamine secretion
E0015276molecular_functionligand-gated monoatomic ion channel activity
E0015464molecular_functionacetylcholine receptor activity
E0016020cellular_componentmembrane
E0019233biological_processsensory perception of pain
E0021562biological_processvestibulocochlear nerve development
E0021631biological_processoptic nerve morphogenesis
E0021771biological_processlateral geniculate nucleus development
E0021952biological_processcentral nervous system projection neuron axonogenesis
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0030890biological_processpositive regulation of B cell proliferation
E0032225biological_processregulation of synaptic transmission, dopaminergic
E0033603biological_processpositive regulation of dopamine secretion
E0034220biological_processmonoatomic ion transmembrane transport
E0034703cellular_componentcation channel complex
E0035094biological_processresponse to nicotine
E0035095biological_processbehavioral response to nicotine
E0035176biological_processsocial behavior
E0042053biological_processregulation of dopamine metabolic process
E0042113biological_processB cell activation
E0042166molecular_functionacetylcholine binding
E0042220biological_processresponse to cocaine
E0042320biological_processregulation of circadian sleep/wake cycle, REM sleep
E0043005cellular_componentneuron projection
E0044853cellular_componentplasma membrane raft
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0045471biological_processresponse to ethanol
E0045759biological_processnegative regulation of action potential
E0048814biological_processregulation of dendrite morphogenesis
E0050877biological_processnervous system process
E0050890biological_processcognition
E0051899biological_processmembrane depolarization
E0051963biological_processregulation of synapse assembly
E0060078biological_processregulation of postsynaptic membrane potential
E0060079biological_processexcitatory postsynaptic potential
E0060084biological_processsynaptic transmission involved in micturition
E0095500biological_processacetylcholine receptor signaling pathway
E0097060cellular_componentsynaptic membrane
E0098878cellular_componentneurotransmitter receptor complex
E1905144biological_processresponse to acetylcholine
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CkIeVkhFPfDqqnC
ChainResidueDetails
BCYS130-CYS144
ACYS135-CYS149

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
FTYR197-HIS203

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues675
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:29720657, ECO:0007744|PDB:6CNJ
ChainResidueDetails
BTHR1-THR213
BILE258-LEU271
CTHR1-THR213
CILE258-LEU271
ETHR1-THR213
EILE258-LEU271

site_idSWS_FT_FI2
Number of Residues183
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:29720657, ECO:0007744|PDB:6CNJ
ChainResidueDetails
BILE214-SER235
BMET241-LEU257
BVAL272-VAL296
CILE214-SER235
CMET241-LEU257
CVAL272-VAL296
EILE214-SER235
EMET241-LEU257
EVAL272-VAL296

site_idSWS_FT_FI3
Number of Residues420
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29720657, ECO:0007744|PDB:6CNJ
ChainResidueDetails
BASP236-LYS240
BHIS297-ILE433
CASP236-LYS240
CHIS297-ILE433
EASP236-LYS240
EHIS297-ILE433

site_idSWS_FT_FI4
Number of Residues57
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BASP434-PHE453
CASP434-PHE453
EASP434-PHE453

site_idSWS_FT_FI5
Number of Residues3
DetailsSITE: Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site => ECO:0000250|UniProtKB:P12390
ChainResidueDetails
BTHR59
CTHR59
ETHR59

site_idSWS_FT_FI6
Number of Residues6
DetailsSITE: Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA => ECO:0000250|UniProtKB:P12390
ChainResidueDetails
BVAL111
BPHE119
CVAL111
CPHE119
EVAL111
EPHE119

site_idSWS_FT_FI7
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27698419, ECO:0007744|PDB:5KXI
ChainResidueDetails
BASN26
CASN26
EASN26

site_idSWS_FT_FI8
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN143
BASN460
CASN143
CASN460
EASN143
EASN460

site_idSWS_FT_FI9
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P04757
ChainResidueDetails
ACYS245
DCYS245

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN31
AASN81
DASN31
DASN81

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27698419, ECO:0007744|PDB:5KXI
ChainResidueDetails
AASN148
DASN148

237992

PDB entries from 2025-06-25

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