8SSW
Crystal structure of DEAD-box RNA helicase DDX3X in complex with ADP at pre-unwound state
Functional Information from PROSITE/UniProt
| site_id | PS00039 |
| Number of Residues | 9 |
| Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL |
| Chain | Residue | Details |
| A | VAL345-LEU353 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | TYR200 | |
| A | ALA224 | |
| B | TYR200 | |
| B | ALA224 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine; by TBK1; in vitro => ECO:0000269|PubMed:18583960 |
| Chain | Residue | Details |
| A | SER181 | |
| B | SER442 | |
| B | SER456 | |
| B | SER520 | |
| A | SER240 | |
| A | SER269 | |
| A | SER442 | |
| A | SER456 | |
| A | SER520 | |
| B | SER181 | |
| B | SER240 | |
| B | SER269 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:18583960, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER183 | |
| B | SER183 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CSNK1E and TBK1; in vitro => ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | SER429 | |
| A | SER543 | |
| B | SER429 | |
| B | SER543 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by TBK1; in vitro => ECO:0000269|PubMed:18583960 |
| Chain | Residue | Details |
| A | THR438 | |
| A | THR542 | |
| B | THR438 | |
| B | THR542 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by CSNK1E; in vitro => ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | THR469 | |
| B | THR469 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CSNK1E; in vitro => ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | SER470 | |
| B | SER470 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | ARG592 | |
| B | ARG592 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER594 | |
| A | SER605 | |
| B | SER594 | |
| B | SER605 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS215 | |
| B | LYS215 |
