8SRP

FoxP3 forms Ladder-like multimer to bridge TTTG repeats

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0043565	molecular_function	sequence-specific DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0043565	molecular_function	sequence-specific DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0043565	molecular_function	sequence-specific DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0043565	molecular_function	sequence-specific DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0043565	molecular_function	sequence-specific DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0043565	molecular_function	sequence-specific DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0043565	molecular_function	sequence-specific DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0006355	biological_process	regulation of DNA-templated transcription
I	0043565	molecular_function	sequence-specific DNA binding
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0006355	biological_process	regulation of DNA-templated transcription
J	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	24
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CkwpgCekvFeepeeflkHcqad.H

Chain	Residue	Details
A	CYS198-HIS221

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site_id	PS00658
Number of Residues	7
Details	FORK_HEAD_2 Fork head domain signature 2. WKNAIRH

Chain	Residue	Details
A	TRP381-HIS387

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	250
Details	ZN_FING: C2H2-type

Chain	Residue	Details
A	GLY196-HIS221
I	GLY196-HIS221
J	GLY196-HIS221
H	GLY196-HIS221
G	GLY196-HIS221
F	GLY196-HIS221
E	GLY196-HIS221
D	GLY196-HIS221
C	GLY196-HIS221
B	GLY196-HIS221

---

site_id	SWS_FT_FI2
Number of Residues	860
Details	DNA_BIND: Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089

Chain	Residue	Details
A	ARG337-LYS423
I	ARG337-LYS423
J	ARG337-LYS423
H	ARG337-LYS423
G	ARG337-LYS423
F	ARG337-LYS423
E	ARG337-LYS423
D	ARG337-LYS423
C	ARG337-LYS423
B	ARG337-LYS423

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	SITE: Cleavage; by PCSK1 or PCSK2 => ECO:0000269|PubMed:19117830

Chain	Residue	Details
A	ARG417
I	ARG417
J	ARG417
H	ARG417
G	ARG417
F	ARG417
E	ARG417
D	ARG417
C	ARG417
B	ARG417

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site_id	SWS_FT_FI4
Number of Residues	20
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:22312127

Chain	Residue	Details
A	LYS262
A	LYS267
I	LYS262
I	LYS267
J	LYS262
J	LYS267
H	LYS262
H	LYS267
G	LYS262
G	LYS267
F	LYS262
F	LYS267
E	LYS262
E	LYS267
D	LYS262
D	LYS267
C	LYS262
C	LYS267
B	LYS262
B	LYS267

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9BZS1

Chain	Residue	Details
A	SER418
I	SER418
J	SER418
H	SER418
G	SER418
F	SER418
E	SER418
D	SER418
C	SER418
B	SER418

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23973222

Chain	Residue	Details
A	LYS249
A	LYS251
A	LYS393
I	LYS249
I	LYS251
I	LYS393
J	LYS249
J	LYS251
J	LYS393
H	LYS249
H	LYS251
H	LYS393
G	LYS249
G	LYS251
G	LYS393
F	LYS249
F	LYS251
F	LYS393
E	LYS249
E	LYS251
E	LYS393
D	LYS249
D	LYS251
D	LYS393
C	LYS249
C	LYS251
C	LYS393
B	LYS249
B	LYS251
B	LYS393

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site_id	SWS_FT_FI7
Number of Residues	20
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:23973222

Chain	Residue	Details
A	LYS262
A	LYS267
I	LYS262
I	LYS267
J	LYS262
J	LYS267
H	LYS262
H	LYS267
G	LYS262
G	LYS267
F	LYS262
F	LYS267
E	LYS262
E	LYS267
D	LYS262
D	LYS267
C	LYS262
C	LYS267
B	LYS262
B	LYS267

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