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8SOR

Structure of human PI3KC3-C1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005776cellular_componentautophagosome
A0005829cellular_componentcytosol
A0005930cellular_componentaxoneme
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006622biological_processprotein targeting to lysosome
A0006623biological_processprotein targeting to vacuole
A0010506biological_processregulation of autophagy
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016310biological_processphosphorylation
A0030670cellular_componentphagocytic vesicle membrane
A0032465biological_processregulation of cytokinesis
A0032801biological_processreceptor catabolic process
A0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
A0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
A0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0042149biological_processcellular response to glucose starvation
A0043231cellular_componentintracellular membrane-bounded organelle
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0044024molecular_functionhistone H2AS1 kinase activity
A0045022biological_processearly endosome to late endosome transport
A0045324biological_processlate endosome to vacuole transport
A0071561cellular_componentnucleus-vacuole junction
A0097352biological_processautophagosome maturation
A0106310molecular_functionprotein serine kinase activity
B0000045biological_processautophagosome assembly
B0000407cellular_componentphagophore assembly site
B0004672molecular_functionprotein kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005770cellular_componentlate endosome
B0005776cellular_componentautophagosome
B0005777cellular_componentperoxisome
B0005829cellular_componentcytosol
B0005930cellular_componentaxoneme
B0006497biological_processprotein lipidation
B0006622biological_processprotein targeting to lysosome
B0006629biological_processlipid metabolic process
B0006897biological_processendocytosis
B0006914biological_processautophagy
B0009267biological_processcellular response to starvation
B0010506biological_processregulation of autophagy
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0016301molecular_functionkinase activity
B0016303molecular_function1-phosphatidylinositol-3-kinase activity
B0016310biological_processphosphorylation
B0030496cellular_componentmidbody
B0030670cellular_componentphagocytic vesicle membrane
B0032465biological_processregulation of cytokinesis
B0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
B0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
B0034497biological_processprotein localization to phagophore assembly site
B0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
B0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
B0042149biological_processcellular response to glucose starvation
B0044754cellular_componentautolysosome
B0044829biological_processpositive regulation by host of viral genome replication
B0045022biological_processearly endosome to late endosome transport
B0045335cellular_componentphagocytic vesicle
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0048015biological_processphosphatidylinositol-mediated signaling
B0048488biological_processsynaptic vesicle endocytosis
B0051301biological_processcell division
B0052742molecular_functionphosphatidylinositol kinase activity
B0097352biological_processautophagosome maturation
B0098794cellular_componentpostsynapse
B0098830cellular_componentpresynaptic endosome
B0098845cellular_componentpostsynaptic endosome
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
C0000045biological_processautophagosome assembly
C0000407cellular_componentphagophore assembly site
C0000421cellular_componentautophagosome membrane
C0000423biological_processmitophagy
C0001932biological_processregulation of protein phosphorylation
C0001933biological_processnegative regulation of protein phosphorylation
C0001934biological_processpositive regulation of protein phosphorylation
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005776cellular_componentautophagosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005930cellular_componentaxoneme
C0006622biological_processprotein targeting to lysosome
C0006914biological_processautophagy
C0008333biological_processendosome to lysosome transport
C0009267biological_processcellular response to starvation
C0010608biological_processpost-transcriptional regulation of gene expression
C0016020cellular_componentmembrane
C0016236biological_processmacroautophagy
C0016240biological_processautophagosome membrane docking
C0016241biological_processregulation of macroautophagy
C0031410cellular_componentcytoplasmic vesicle
C0032991cellular_componentprotein-containing complex
C0034045cellular_componentphagophore assembly site membrane
C0035014molecular_functionphosphatidylinositol 3-kinase regulator activity
C0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
C0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
C0042149biological_processcellular response to glucose starvation
C0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
C0043495molecular_functionprotein-membrane adaptor activity
C0044233cellular_componentmitochondria-associated endoplasmic reticulum membrane contact site
C0045022biological_processearly endosome to late endosome transport
C0045087biological_processinnate immune response
C0045335cellular_componentphagocytic vesicle
C0051020molecular_functionGTPase binding
C0051607biological_processdefense response to virus
C0061635biological_processregulation of protein complex stability
C0090207biological_processregulation of triglyceride metabolic process
C0097352biological_processautophagosome maturation
C0097629cellular_componentextrinsic component of omegasome membrane
C0097632cellular_componentextrinsic component of phagophore assembly site membrane
C0098780biological_processresponse to mitochondrial depolarisation
C0141039molecular_functionphosphatidylinositol 3-kinase inhibitor activity
D0000045biological_processautophagosome assembly
D0000407cellular_componentphagophore assembly site
D0000423biological_processmitophagy
D0001666biological_processresponse to hypoxia
D0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005768cellular_componentendosome
D0005776cellular_componentautophagosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005802cellular_componenttrans-Golgi network
D0005829cellular_componentcytosol
D0006622biological_processprotein targeting to lysosome
D0006897biological_processendocytosis
D0006914biological_processautophagy
D0006915biological_processapoptotic process
D0006968biological_processcellular defense response
D0006995biological_processcellular response to nitrogen starvation
D0007040biological_processlysosome organization
D0007080biological_processmitotic metaphase chromosome alignment
D0007254biological_processJNK cascade
D0008285biological_processnegative regulation of cell population proliferation
D0009410biological_processresponse to xenobiotic stimulus
D0010008cellular_componentendosome membrane
D0010040biological_processresponse to iron(II) ion
D0010288biological_processresponse to lead ion
D0010506biological_processregulation of autophagy
D0010507biological_processnegative regulation of autophagy
D0010508biological_processpositive regulation of autophagy
D0010613biological_processpositive regulation of cardiac muscle hypertrophy
D0016020cellular_componentmembrane
D0016236biological_processmacroautophagy
D0016241biological_processregulation of macroautophagy
D0016604cellular_componentnuclear body
D0019901molecular_functionprotein kinase binding
D0030425cellular_componentdendrite
D0030674molecular_functionprotein-macromolecule adaptor activity
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0031667biological_processresponse to nutrient levels
D0031966cellular_componentmitochondrial membrane
D0032465biological_processregulation of cytokinesis
D0032473cellular_componentcytoplasmic side of mitochondrial outer membrane
D0032801biological_processreceptor catabolic process
D0032991cellular_componentprotein-containing complex
D0033197biological_processresponse to vitamin E
D0034198biological_processcellular response to amino acid starvation
D0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
D0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
D0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
D0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
D0038066biological_processp38MAPK cascade
D0039521biological_processsuppression by virus of host autophagy
D0042149biological_processcellular response to glucose starvation
D0042802molecular_functionidentical protein binding
D0043066biological_processnegative regulation of apoptotic process
D0043069biological_processnegative regulation of programmed cell death
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0043652biological_processengulfment of apoptotic cell
D0045022biological_processearly endosome to late endosome transport
D0045324biological_processlate endosome to vacuole transport
D0045335cellular_componentphagocytic vesicle
D0048666biological_processneuron development
D0050435biological_processamyloid-beta metabolic process
D0051020molecular_functionGTPase binding
D0051301biological_processcell division
D0051607biological_processdefense response to virus
D0051707biological_processresponse to other organism
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0060090molecular_functionmolecular adaptor activity
D0060395biological_processSMAD protein signal transduction
D0062029biological_processpositive regulation of stress granule assembly
D0065003biological_processprotein-containing complex assembly
D0070301biological_processcellular response to hydrogen peroxide
D0071275biological_processcellular response to aluminum ion
D0071280biological_processcellular response to copper ion
D0071364biological_processcellular response to epidermal growth factor stimulus
D0090650biological_processcellular response to oxygen-glucose deprivation
D0097352biological_processautophagosome maturation
D0098780biological_processresponse to mitochondrial depolarisation
D1902425biological_processpositive regulation of attachment of mitotic spindle microtubules to kinetochore
D1902902biological_processnegative regulation of autophagosome assembly
D1905672biological_processnegative regulation of lysosome organization
D2000378biological_processnegative regulation of reactive oxygen species metabolic process
D2000786biological_processpositive regulation of autophagosome assembly
D2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VrHgDIKteNVMV
ChainResidueDetails
AVAL144-VAL156

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. IAAVqgNnEVSMWDM
ChainResidueDetails
AILE1201-MET1215
ALEU1256-LEU1270

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDqlilQ
ChainResidueDetails
BPHE635-GLN649

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYILgVgDRHldN
ChainResidueDetails
BSER728-ASN748

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP148

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU32
ALYS53

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER808
ASER853
ASER865

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER813

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ATHR1316

site_idSWS_FT_FI6
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:8999962
ChainResidueDetails
AGLY2

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by DAPK1 => ECO:0000269|PubMed:19180116
ChainResidueDetails
DTHR119

site_idSWS_FT_FI8
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:28445460
ChainResidueDetails
DLYS402

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23974797
ChainResidueDetails
DLYS437

224004

PDB entries from 2024-08-21

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