8SOJ

Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006974	biological_process	DNA damage response
A	0008643	biological_process	carbohydrate transport
A	0010833	biological_process	telomere maintenance via telomere lengthening
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0016233	biological_process	telomere capping
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0032211	biological_process	negative regulation of telomere maintenance via telomerase
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042162	molecular_function	telomeric DNA binding
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0045740	biological_process	positive regulation of DNA replication
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	0098505	molecular_function	G-rich strand telomeric DNA binding
A	1901982	molecular_function	maltose binding
A	1990879	cellular_component	CST complex
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0000783	cellular_component	nuclear telomere cap complex
B	0003677	molecular_function	DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005697	cellular_component	telomerase holoenzyme complex
B	0006091	biological_process	generation of precursor metabolites and energy
B	0007004	biological_process	telomere maintenance via telomerase
B	0008218	biological_process	bioluminescence
B	0010833	biological_process	telomere maintenance via telomere lengthening
B	0016233	biological_process	telomere capping
B	0032211	biological_process	negative regulation of telomere maintenance via telomerase
B	0042162	molecular_function	telomeric DNA binding
B	0043047	molecular_function	single-stranded telomeric DNA binding
B	0045740	biological_process	positive regulation of DNA replication
B	0051052	biological_process	regulation of DNA metabolic process
B	0070187	cellular_component	shelterin complex
B	1990879	cellular_component	CST complex
C	0000781	cellular_component	chromosome, telomeric region
C	0003677	molecular_function	DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0010521	molecular_function	telomerase inhibitor activity
C	0016233	biological_process	telomere capping
C	0032211	biological_process	negative regulation of telomere maintenance via telomerase
C	0042162	molecular_function	telomeric DNA binding
C	1990879	cellular_component	CST complex
D	0000723	biological_process	telomere maintenance
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0043047	molecular_function	single-stranded telomeric DNA binding

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO-275-ASN-258

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	DNA binding: {"description":"OB"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	104
Details	Region: {"description":"Winged helix-turn-helix (wHTH) 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Region: {"description":"DNA-binding"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"DNA-binding"}

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Residue

Details

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