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8SOB

Phosphoinositide phosphate 3 kinase gamma bound with ADP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002376biological_processimmune system process
A0004674molecular_functionprotein serine/threonine kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005943cellular_componentphosphatidylinositol 3-kinase complex, class IA
A0005944cellular_componentphosphatidylinositol 3-kinase complex, class IB
A0006338biological_processchromatin remodeling
A0006629biological_processlipid metabolic process
A0006897biological_processendocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0016310biological_processphosphorylation
A0035005molecular_function1-phosphatidylinositol-4-phosphate 3-kinase activity
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0044024molecular_functionhistone H2AS1 kinase activity
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0046934molecular_function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
A0048015biological_processphosphatidylinositol-mediated signaling
A0106310molecular_functionprotein serine kinase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005942cellular_componentphosphatidylinositol 3-kinase complex
B0005944cellular_componentphosphatidylinositol 3-kinase complex, class IB
B0007186biological_processG protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0043406biological_processpositive regulation of MAP kinase activity
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0046935molecular_function1-phosphatidylinositol-3-kinase regulator activity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ
ChainResidueDetails
APHE832-GLN846

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN
ChainResidueDetails
ASER931-ASN951

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:9094719
ChainResidueDetails
BMET1
ALEU864
APHE961

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8WYR1
ChainResidueDetails
BSER456
BSER505

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P48736
ChainResidueDetails
ASER1101

226707

PDB entries from 2024-10-30

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