8SO3
CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR196-HIS202 | |
| H | TYR198-HIS204 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 854 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| D | LEU23-LEU450 | |
| X | LEU23-LEU450 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| D | LEU451-PHE471 | |
| X | LEU451-PHE471 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 106 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| D | HIS472-LEU525 | |
| X | HIS472-LEU525 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN188 | |
| D | ASN250 | |
| D | ASN256 | |
| D | ASN343 | |
| X | ASN188 | |
| X | ASN250 | |
| X | ASN256 | |
| X | ASN343 |
