8SO3
CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR196-HIS202 | |
| H | TYR198-HIS204 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 168 |
| Details | Domain: {"description":"Ig-like C2-type 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35761082","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37619561","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TZG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SO3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35761082","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37619561","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39671469","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TZG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SO3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BF9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35761082","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
