8SJY
Structure of lens aquaporin-0 array in sphingomyelin/cholesterol bilayer (1SM:2Chol)
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 66 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | MET1-SER8 | |
| A | SER79-LEU84 | |
| A | THR148-SER159 | |
| A | ASP220-LEU263 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 121 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | PHE9-LEU32 | |
| A | LEU39-HIS61 | |
| A | ARG85-VAL107 | |
| A | VAL127-ALA147 | |
| A | VAL160-MET176 | |
| A | HIS201-TYR219 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| A | ARG33-PRO38 | |
| A | THR108-SER126 | |
| A | THR195-ASN200 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | ILE62-VAL67 | |
| A | TYR177-MET183 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | INTRAMEM: Helical |
| Chain | Residue | Details |
| A | ASN68-GLY78 | |
| A | ASN184-LEU194 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Important for water channel gating => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR149 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Interaction with BFSP1 => ECO:0000250|UniProtKB:P06624 |
| Chain | Residue | Details |
| A | ASN246 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: interaction with BFSP1 => ECO:0000250|UniProtKB:P06624 |
| Chain | Residue | Details |
| A | GLU250 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06624 |
| Chain | Residue | Details |
| A | SER235 | |
| A | SER243 | |
| A | SER245 |
