8SEK
Type IIIa beta-amyloid 40 Filaments from Down syndrome
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| B | 0016020 | cellular_component | membrane |
| C | 0016020 | cellular_component | membrane |
| D | 0016020 | cellular_component | membrane |
| E | 0016020 | cellular_component | membrane |
| F | 0016020 | cellular_component | membrane |
| G | 0016020 | cellular_component | membrane |
| H | 0016020 | cellular_component | membrane |
| I | 0016020 | cellular_component | membrane |
| J | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | HIS6 | |
| E | HIS14 | |
| F | HIS6 | |
| F | HIS14 | |
| G | HIS6 | |
| G | HIS14 | |
| H | HIS6 | |
| H | HIS14 | |
| I | HIS6 | |
| I | HIS14 | |
| J | HIS6 | |
| A | HIS14 | |
| J | HIS14 | |
| B | HIS6 | |
| B | HIS14 | |
| C | HIS6 | |
| C | HIS14 | |
| D | HIS6 | |
| D | HIS14 | |
| E | HIS6 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| A | TYR10 | |
| J | TYR10 | |
| B | TYR10 | |
| C | TYR10 | |
| D | TYR10 | |
| E | TYR10 | |
| F | TYR10 | |
| G | TYR10 | |
| H | TYR10 | |
| I | TYR10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | HIS13 | |
| J | HIS13 | |
| B | HIS13 | |
| C | HIS13 | |
| D | HIS13 | |
| E | HIS13 | |
| F | HIS13 | |
| G | HIS13 | |
| H | HIS13 | |
| I | HIS13 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| A | ASP1 | |
| J | ASP1 | |
| B | ASP1 | |
| C | ASP1 | |
| D | ASP1 | |
| E | ASP1 | |
| F | ASP1 | |
| G | ASP1 | |
| H | ASP1 | |
| I | ASP1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| A | ASP7 | |
| J | ASP7 | |
| B | ASP7 | |
| C | ASP7 | |
| D | ASP7 | |
| E | ASP7 | |
| F | ASP7 | |
| G | ASP7 | |
| H | ASP7 | |
| I | ASP7 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| A | LYS16 | |
| J | LYS16 | |
| B | LYS16 | |
| C | LYS16 | |
| D | LYS16 | |
| E | LYS16 | |
| F | LYS16 | |
| G | LYS16 | |
| H | LYS16 | |
| I | LYS16 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
| Chain | Residue | Details |
| A | PHE19 | |
| J | PHE19 | |
| B | PHE19 | |
| C | PHE19 | |
| D | PHE19 | |
| E | PHE19 | |
| F | PHE19 | |
| G | PHE19 | |
| H | PHE19 | |
| I | PHE19 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | SITE: Implicated in free radical propagation => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY33 | |
| J | GLY33 | |
| B | GLY33 | |
| C | GLY33 | |
| D | GLY33 | |
| E | GLY33 | |
| F | GLY33 | |
| G | GLY33 | |
| H | GLY33 | |
| I | GLY33 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332 |
| Chain | Residue | Details |
| A | MET35 | |
| J | MET35 | |
| B | MET35 | |
| C | MET35 | |
| D | MET35 | |
| E | MET35 | |
| F | MET35 | |
| G | MET35 | |
| H | MET35 | |
| I | MET35 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| A | VAL40 | |
| J | VAL40 | |
| B | VAL40 | |
| C | VAL40 | |
| D | VAL40 | |
| E | VAL40 | |
| F | VAL40 | |
| G | VAL40 | |
| H | VAL40 | |
| I | VAL40 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| A | TYR10 | |
| J | TYR10 | |
| B | TYR10 | |
| C | TYR10 | |
| D | TYR10 | |
| E | TYR10 | |
| F | TYR10 | |
| G | TYR10 | |
| H | TYR10 | |
| I | TYR10 |
