8SE3
Structure of Full-length Human Protein Kinase C Beta 1 (PKCBI) in the Active Conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0002376 | biological_process | immune system process |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004697 | molecular_function | diacylglycerol-dependent serine/threonine kinase activity |
| A | 0004698 | molecular_function | calcium,diacylglycerol-dependent serine/threonine kinase activity |
| A | 0005080 | molecular_function | protein kinase C binding |
| A | 0005246 | molecular_function | calcium channel regulator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0006874 | biological_process | intracellular calcium ion homeostasis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007077 | biological_process | mitotic nuclear membrane disassembly |
| A | 0007165 | biological_process | signal transduction |
| A | 0007207 | biological_process | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway |
| A | 0008091 | cellular_component | spectrin |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0010827 | biological_process | regulation of D-glucose transmembrane transport |
| A | 0010829 | biological_process | negative regulation of D-glucose transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030949 | biological_process | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| A | 0032024 | biological_process | positive regulation of insulin secretion |
| A | 0035403 | molecular_function | histone H3T6 kinase activity |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042113 | biological_process | B cell activation |
| A | 0042393 | molecular_function | histone binding |
| A | 0042953 | biological_process | lipoprotein transport |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0044305 | cellular_component | calyx of Held |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0046627 | biological_process | negative regulation of insulin receptor signaling pathway |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050681 | molecular_function | nuclear androgen receptor binding |
| A | 0050853 | biological_process | B cell receptor signaling pathway |
| A | 0051049 | biological_process | regulation of transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070528 | biological_process | protein kinase C signaling |
| A | 0071322 | biological_process | cellular response to carbohydrate stimulus |
| A | 0099171 | biological_process | presynaptic modulation of chemical synaptic transmission |
| A | 0099523 | cellular_component | presynaptic cytosol |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 2000300 | biological_process | regulation of synaptic vesicle exocytosis |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGSFGKVMlSerkgtdel..........YAVK |
| Chain | Residue | Details |
| A | LEU348-LYS371 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKldNVML |
| Chain | Residue | Details |
| A | ILE462-LEU474 |
| site_id | PS00479 |
| Number of Residues | 50 |
| Details | ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HkFtarffkqptf.CshCtdfIwgfgkqgfq.CqvCcfvvHkrChefvtfs..C |
| Chain | Residue | Details |
| A | HIS37-CYS86 | |
| A | HIS102-CYS151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 117 |
| Details | Domain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Zinc finger: {"description":"Phorbol-ester/DAG-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | Zinc finger: {"description":"Phorbol-ester/DAG-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P68403","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"17115692","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"P68403","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17115692","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"17115692","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
