8S91

Structure of Walker B mutated MCM8/9 heterohexamer complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006259	biological_process	DNA metabolic process
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0007292	biological_process	female gamete generation
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017116	molecular_function	single-stranded DNA helicase activity
A	0019899	molecular_function	enzyme binding
A	0032406	molecular_function	MutLbeta complex binding
A	0032407	molecular_function	MutSalpha complex binding
A	0032408	molecular_function	MutSbeta complex binding
A	0032508	biological_process	DNA duplex unwinding
A	0036298	biological_process	recombinational interstrand cross-link repair
A	0042555	cellular_component	MCM complex
A	0048232	biological_process	male gamete generation
A	0050821	biological_process	protein stabilization
A	0070716	biological_process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
A	0071168	biological_process	protein localization to chromatin
A	0097362	cellular_component	MCM8-MCM9 complex
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003697	molecular_function	single-stranded DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006259	biological_process	DNA metabolic process
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0007292	biological_process	female gamete generation
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017116	molecular_function	single-stranded DNA helicase activity
B	0019899	molecular_function	enzyme binding
B	0032406	molecular_function	MutLbeta complex binding
B	0032407	molecular_function	MutSalpha complex binding
B	0032408	molecular_function	MutSbeta complex binding
B	0032508	biological_process	DNA duplex unwinding
B	0036298	biological_process	recombinational interstrand cross-link repair
B	0042555	cellular_component	MCM complex
B	0048232	biological_process	male gamete generation
B	0050821	biological_process	protein stabilization
B	0070716	biological_process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
B	0071168	biological_process	protein localization to chromatin
B	0097362	cellular_component	MCM8-MCM9 complex
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003697	molecular_function	single-stranded DNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006259	biological_process	DNA metabolic process
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0007292	biological_process	female gamete generation
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0017116	molecular_function	single-stranded DNA helicase activity
C	0019899	molecular_function	enzyme binding
C	0032406	molecular_function	MutLbeta complex binding
C	0032407	molecular_function	MutSalpha complex binding
C	0032408	molecular_function	MutSbeta complex binding
C	0032508	biological_process	DNA duplex unwinding
C	0036298	biological_process	recombinational interstrand cross-link repair
C	0042555	cellular_component	MCM complex
C	0048232	biological_process	male gamete generation
C	0050821	biological_process	protein stabilization
C	0070716	biological_process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
C	0071168	biological_process	protein localization to chromatin
C	0097362	cellular_component	MCM8-MCM9 complex
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0003682	molecular_function	chromatin binding
D	0003697	molecular_function	single-stranded DNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006259	biological_process	DNA metabolic process
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0007276	biological_process	gamete generation
D	0007292	biological_process	female gamete generation
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017116	molecular_function	single-stranded DNA helicase activity
D	0019899	molecular_function	enzyme binding
D	0032406	molecular_function	MutLbeta complex binding
D	0032407	molecular_function	MutSalpha complex binding
D	0032408	molecular_function	MutSbeta complex binding
D	0032508	biological_process	DNA duplex unwinding
D	0036298	biological_process	recombinational interstrand cross-link repair
D	0042555	cellular_component	MCM complex
D	0044877	molecular_function	protein-containing complex binding
D	0070716	biological_process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
D	0071168	biological_process	protein localization to chromatin
D	0097362	cellular_component	MCM8-MCM9 complex
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0003682	molecular_function	chromatin binding
E	0003697	molecular_function	single-stranded DNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006259	biological_process	DNA metabolic process
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006974	biological_process	DNA damage response
E	0007276	biological_process	gamete generation
E	0007292	biological_process	female gamete generation
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0017116	molecular_function	single-stranded DNA helicase activity
E	0019899	molecular_function	enzyme binding
E	0032406	molecular_function	MutLbeta complex binding
E	0032407	molecular_function	MutSalpha complex binding
E	0032408	molecular_function	MutSbeta complex binding
E	0032508	biological_process	DNA duplex unwinding
E	0036298	biological_process	recombinational interstrand cross-link repair
E	0042555	cellular_component	MCM complex
E	0044877	molecular_function	protein-containing complex binding
E	0070716	biological_process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
E	0071168	biological_process	protein localization to chromatin
E	0097362	cellular_component	MCM8-MCM9 complex
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0003682	molecular_function	chromatin binding
F	0003697	molecular_function	single-stranded DNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006259	biological_process	DNA metabolic process
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006974	biological_process	DNA damage response
F	0007276	biological_process	gamete generation
F	0007292	biological_process	female gamete generation
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017116	molecular_function	single-stranded DNA helicase activity
F	0019899	molecular_function	enzyme binding
F	0032406	molecular_function	MutLbeta complex binding
F	0032407	molecular_function	MutSalpha complex binding
F	0032408	molecular_function	MutSbeta complex binding
F	0032508	biological_process	DNA duplex unwinding
F	0036298	biological_process	recombinational interstrand cross-link repair
F	0042555	cellular_component	MCM complex
F	0044877	molecular_function	protein-containing complex binding
F	0070716	biological_process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
F	0071168	biological_process	protein localization to chromatin
F	0097362	cellular_component	MCM8-MCM9 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
D	GLY352
E	GLY352
F	GLY352

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site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER762
E	SER762
F	SER762

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site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER802
D	SER1109
E	SER802
E	SER1109
F	SER802
F	SER1109

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