8S24
Structure of the E3 ubiquitin ligase RNF213, determined by cryoEM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0002040 | biological_process | sprouting angiogenesis |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005829 | cellular_component | cytosol |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0019216 | biological_process | regulation of lipid metabolic process |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051865 | biological_process | protein autoubiquitination |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| A | 0070534 | biological_process | protein K63-linked ubiquitination |
| A | 0098792 | biological_process | xenophagy |
| A | 0120323 | biological_process | lipid ubiquitination |
| A | 0140042 | biological_process | lipid droplet formation |
| A | 2000051 | biological_process | negative regulation of non-canonical Wnt signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39375464","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40205224","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8S24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9G08","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9G09","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39375464","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40205224","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8S24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9G09","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40205224","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9G09","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40164614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9JTA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40164614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40205224","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9G09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9JTA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01325","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"39375464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8S24","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01325","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01325","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"40205224","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9G09","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
