8S24

Structure of the E3 ubiquitin ligase RNF213, determined by cryoEM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001525	biological_process	angiogenesis
A	0002040	biological_process	sprouting angiogenesis
A	0002376	biological_process	immune system process
A	0003824	molecular_function	catalytic activity
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005524	molecular_function	ATP binding
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006629	biological_process	lipid metabolic process
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019216	biological_process	regulation of lipid metabolic process
A	0042742	biological_process	defense response to bacterium
A	0046872	molecular_function	metal ion binding
A	0051865	biological_process	protein autoubiquitination
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070534	biological_process	protein K63-linked ubiquitination
A	0098792	biological_process	xenophagy
A	0120323	biological_process	lipid ubiquitination
A	0140042	biological_process	lipid droplet formation
A	2000051	biological_process	negative regulation of non-canonical Wnt signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"E9Q555","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01325","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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