8RY4

CryoEM structure of M. smegmatis GMP reductase in complex with GMP and GTP at pH 6.6, extended conformation II.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003920	molecular_function	GMP reductase activity
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0032264	biological_process	IMP salvage
B	0003824	molecular_function	catalytic activity
B	0003920	molecular_function	GMP reductase activity
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0032264	biological_process	IMP salvage
C	0003824	molecular_function	catalytic activity
C	0003920	molecular_function	GMP reductase activity
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0032264	biological_process	IMP salvage
D	0003824	molecular_function	catalytic activity
D	0003920	molecular_function	GMP reductase activity
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0032264	biological_process	IMP salvage
E	0003824	molecular_function	catalytic activity
E	0003920	molecular_function	GMP reductase activity
E	0005829	cellular_component	cytosol
E	0006166	biological_process	purine ribonucleoside salvage
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0032264	biological_process	IMP salvage
F	0003824	molecular_function	catalytic activity
F	0003920	molecular_function	GMP reductase activity
F	0005829	cellular_component	cytosol
F	0006166	biological_process	purine ribonucleoside salvage
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0032264	biological_process	IMP salvage
G	0003824	molecular_function	catalytic activity
G	0003920	molecular_function	GMP reductase activity
G	0005829	cellular_component	cytosol
G	0006166	biological_process	purine ribonucleoside salvage
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0032264	biological_process	IMP salvage
H	0003824	molecular_function	catalytic activity
H	0003920	molecular_function	GMP reductase activity
H	0005829	cellular_component	cytosol
H	0006166	biological_process	purine ribonucleoside salvage
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0032264	biological_process	IMP salvage

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	456
Details	Domain: {"description":"CBS 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00703","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	464
Details	Domain: {"description":"CBS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00703","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Active site: {"description":"Thioimidate intermediate","evidences":[{"source":"UniProtKB","id":"P50097","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P50097","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---