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8RWZ

Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL

Functional Information from GO Data
ChainGOidnamespacecontents
C0006368biological_processtranscription elongation by RNA polymerase II
C0030891cellular_componentVCB complex
C0070449cellular_componentelongin complex
D0006511biological_processubiquitin-dependent protein catabolic process
E0000082biological_processG1/S transition of mitotic cell cycle
E0004842molecular_functionubiquitin-protein transferase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005829cellular_componentcytosol
E0006511biological_processubiquitin-dependent protein catabolic process
E0016567biological_processprotein ubiquitination
E0019005cellular_componentSCF ubiquitin ligase complex
E0030163biological_processprotein catabolic process
E0030674molecular_functionprotein-macromolecule adaptor activity
E0030891cellular_componentVCB complex
E0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E0031461cellular_componentcullin-RING ubiquitin ligase complex
E0031462cellular_componentCul2-RING ubiquitin ligase complex
E0031625molecular_functionubiquitin protein ligase binding
E0044877molecular_functionprotein-containing complex binding
E0097193biological_processintrinsic apoptotic signaling pathway
E0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E0160072molecular_functionubiquitin ligase complex scaffold activity
R0000165biological_processMAPK cascade
R0000209biological_processprotein polyubiquitination
R0004842molecular_functionubiquitin-protein transferase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0006281biological_processDNA repair
R0006511biological_processubiquitin-dependent protein catabolic process
R0006513biological_processprotein monoubiquitination
R0006974biological_processDNA damage response
R0007283biological_processspermatogenesis
R0008270molecular_functionzinc ion binding
R0016567biological_processprotein ubiquitination
R0016740molecular_functiontransferase activity
R0019005cellular_componentSCF ubiquitin ligase complex
R0019788molecular_functionNEDD8 transferase activity
R0030163biological_processprotein catabolic process
R0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R0031461cellular_componentcullin-RING ubiquitin ligase complex
R0031462cellular_componentCul2-RING ubiquitin ligase complex
R0031463cellular_componentCul3-RING ubiquitin ligase complex
R0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
R0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
R0031466cellular_componentCul5-RING ubiquitin ligase complex
R0031467cellular_componentCul7-RING ubiquitin ligase complex
R0031625molecular_functionubiquitin protein ligase binding
R0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
R0032480biological_processnegative regulation of type I interferon production
R0034450molecular_functionubiquitin-ubiquitin ligase activity
R0034644biological_processcellular response to UV
R0042110biological_processT cell activation
R0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0043687biological_processpost-translational protein modification
R0045116biological_processprotein neddylation
R0045732biological_processpositive regulation of protein catabolic process
R0046872molecular_functionmetal ion binding
R0060090molecular_functionmolecular adaptor activity
R0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
R0061630molecular_functionubiquitin protein ligase activity
R0061663molecular_functionNEDD8 ligase activity
R0062197biological_processcellular response to chemical stress
R0070936biological_processprotein K48-linked ubiquitination
R0071230biological_processcellular response to amino acid stimulus
R0090090biological_processnegative regulation of canonical Wnt signaling pathway
R0097602molecular_functioncullin family protein binding
R0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R1900076biological_processregulation of cellular response to insulin stimulus
R1902499biological_processpositive regulation of protein autoubiquitination
R1902883biological_processnegative regulation of response to oxidative stress
R1904263biological_processpositive regulation of TORC1 signaling
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkcIevLIDKqYIeRsqasadeYsYvA
ChainResidueDetails
EILE718-ALA745

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues45
DetailsZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
ChainResidueDetails
RCYS53-ASN98

site_idSWS_FT_FI2
Number of Residues11
DetailsBINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DPL, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O
ChainResidueDetails
RCYS42
RCYS94
RASP97
RCYS45
RCYS53
RCYS56
RCYS68
RCYS75
RHIS77
RHIS80
RHIS82

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O
ChainResidueDetails
RCYS83

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
RTHR9

222415

PDB entries from 2024-07-10

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