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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8RWV

Human OCCM DNA licensing intermediate

Functional Information from GO Data
ChainGOidnamespacecontents
20000166molecular_functionnucleotide binding
20000228cellular_componentnuclear chromosome
20000727biological_processdouble-strand break repair via break-induced replication
20000781cellular_componentchromosome, telomeric region
20000785cellular_componentchromatin
20003677molecular_functionDNA binding
20003678molecular_functionDNA helicase activity
20003688molecular_functionDNA replication origin binding
20003697molecular_functionsingle-stranded DNA binding
20004386molecular_functionhelicase activity
20005515molecular_functionprotein binding
20005524molecular_functionATP binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005664cellular_componentnuclear origin of replication recognition complex
20005694cellular_componentchromosome
20005730cellular_componentnucleolus
20005737cellular_componentcytoplasm
20006260biological_processDNA replication
20006270biological_processDNA replication initiation
20006915biological_processapoptotic process
20008270molecular_functionzinc ion binding
20016787molecular_functionhydrolase activity
20016887molecular_functionATP hydrolysis activity
20017116molecular_functionsingle-stranded DNA helicase activity
20019899molecular_functionenzyme binding
20030174biological_processregulation of DNA-templated DNA replication initiation
20042393molecular_functionhistone binding
20042555cellular_componentMCM complex
20043138molecular_function3'-5' DNA helicase activity
20046872molecular_functionmetal ion binding
20071162cellular_componentCMG complex
20090102biological_processcochlea development
21902975biological_processmitotic DNA replication initiation
30000166molecular_functionnucleotide binding
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003678molecular_functionDNA helicase activity
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005515molecular_functionprotein binding
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005658cellular_componentalpha DNA polymerase:primase complex
30005694cellular_componentchromosome
30005730cellular_componentnucleolus
30005737cellular_componentcytoplasm
30006260biological_processDNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30016020cellular_componentmembrane
30016787molecular_functionhydrolase activity
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030174biological_processregulation of DNA-templated DNA replication initiation
30042555cellular_componentMCM complex
30048471cellular_componentperinuclear region of cytoplasm
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
40000166molecular_functionnucleotide binding
40000727biological_processdouble-strand break repair via break-induced replication
40000781cellular_componentchromosome, telomeric region
40003677molecular_functionDNA binding
40003678molecular_functionDNA helicase activity
40003697molecular_functionsingle-stranded DNA binding
40004386molecular_functionhelicase activity
40005515molecular_functionprotein binding
40005524molecular_functionATP binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005694cellular_componentchromosome
40006260biological_processDNA replication
40006270biological_processDNA replication initiation
40006271biological_processDNA strand elongation involved in DNA replication
40016020cellular_componentmembrane
40016787molecular_functionhydrolase activity
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40030174biological_processregulation of DNA-templated DNA replication initiation
40042555cellular_componentMCM complex
40071162cellular_componentCMG complex
41902975biological_processmitotic DNA replication initiation
60000166molecular_functionnucleotide binding
60000727biological_processdouble-strand break repair via break-induced replication
60000781cellular_componentchromosome, telomeric region
60003677molecular_functionDNA binding
60003678molecular_functionDNA helicase activity
60003697molecular_functionsingle-stranded DNA binding
60004386molecular_functionhelicase activity
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005694cellular_componentchromosome
60006260biological_processDNA replication
60006270biological_processDNA replication initiation
60016787molecular_functionhydrolase activity
60016887molecular_functionATP hydrolysis activity
60030174biological_processregulation of DNA-templated DNA replication initiation
60042555cellular_componentMCM complex
60042802molecular_functionidentical protein binding
60071162cellular_componentCMG complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000166molecular_functionnucleotide binding
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70000785cellular_componentchromatin
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005694cellular_componentchromosome
70005730cellular_componentnucleolus
70006260biological_processDNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006974biological_processDNA damage response
70009410biological_processresponse to xenobiotic stimulus
70016020cellular_componentmembrane
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030174biological_processregulation of DNA-templated DNA replication initiation
70042325biological_processregulation of phosphorylation
70042555cellular_componentMCM complex
70071162cellular_componentCMG complex
70071364biological_processcellular response to epidermal growth factor stimulus
A0000166molecular_functionnucleotide binding
A0000781cellular_componentchromosome, telomeric region
A0000808cellular_componentorigin recognition complex
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003688molecular_functionDNA replication origin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005664cellular_componentnuclear origin of replication recognition complex
A0005829cellular_componentcytosol
A0006260biological_processDNA replication
A0006270biological_processDNA replication initiation
A0016887molecular_functionATP hydrolysis activity
A0033314biological_processmitotic DNA replication checkpoint signaling
A0046872molecular_functionmetal ion binding
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0000792cellular_componentheterochromatin
B0000808cellular_componentorigin recognition complex
B0000939cellular_componentinner kinetochore
B0003688molecular_functionDNA replication origin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005664cellular_componentnuclear origin of replication recognition complex
B0005813cellular_componentcentrosome
B0006260biological_processDNA replication
B0006270biological_processDNA replication initiation
B0016020cellular_componentmembrane
C0003677molecular_functionDNA binding
C0005664cellular_componentnuclear origin of replication recognition complex
C0006260biological_processDNA replication
D0000166molecular_functionnucleotide binding
D0000781cellular_componentchromosome, telomeric region
D0000808cellular_componentorigin recognition complex
D0003677molecular_functionDNA binding
D0003688molecular_functionDNA replication origin binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005664cellular_componentnuclear origin of replication recognition complex
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0006260biological_processDNA replication
D0006270biological_processDNA replication initiation
D0040038biological_processpolar body extrusion after meiotic divisions
D0051258biological_processprotein polymerization
E0000166molecular_functionnucleotide binding
E0000781cellular_componentchromosome, telomeric region
E0000785cellular_componentchromatin
E0000808cellular_componentorigin recognition complex
E0003688molecular_functionDNA replication origin binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005664cellular_componentnuclear origin of replication recognition complex
E0005694cellular_componentchromosome
E0006260biological_processDNA replication
E0006270biological_processDNA replication initiation
E0006275biological_processregulation of DNA replication
F0000076biological_processDNA replication checkpoint signaling
F0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
F0000166molecular_functionnucleotide binding
F0000922cellular_componentspindle pole
F0003682molecular_functionchromatin binding
F0003688molecular_functionDNA replication origin binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0006260biological_processDNA replication
F0006270biological_processDNA replication initiation
F0007089biological_processtraversing start control point of mitotic cell cycle
F0008156biological_processnegative regulation of DNA replication
F0008285biological_processnegative regulation of cell population proliferation
F0030071biological_processregulation of mitotic metaphase/anaphase transition
F0032467biological_processpositive regulation of cytokinesis
F0033314biological_processmitotic DNA replication checkpoint signaling
F0048146biological_processpositive regulation of fibroblast proliferation
F0051233cellular_componentspindle midzone
F0051301biological_processcell division
F0051984biological_processpositive regulation of chromosome segregation
F0120283molecular_functionprotein serine/threonine kinase binding
F1904117biological_processcellular response to vasopressin
F1904385biological_processcellular response to angiotensin
G0003677molecular_functionDNA binding
G0030174biological_processregulation of DNA-templated DNA replication initiation
G0071163biological_processDNA replication preinitiation complex assembly
Functional Information from PROSITE/UniProt
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GVVCIDEFD
ChainResidueDetails
3GLY404-ASP412
6GLY455-ASP463
4GLY569-ASP577
7GLY440-ASP448
2GLY582-ASP590
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsZinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues19
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues15
DetailsMotif: {"description":"Arginine finger"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues5
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues829
DetailsDomain: {"description":"MCM"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues31
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Glen H.","Brunton V.G.","Frame M.C."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P25206","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by ATM","evidences":[{"source":"PubMed","id":"15210935","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97311","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues43
DetailsRegion: {"description":"Interaction with RAD17","evidences":[{"source":"PubMed","id":"15538388","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues142
DetailsRegion: {"description":"Interaction with ATRIP"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.","Kolch W."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues360
DetailsRegion: {"description":"Necessary and sufficient for ORC complex assembly"}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28112645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UJ7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28112645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UJM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues21
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues95
DetailsRegion: {"description":"Interaction with LRWD1","evidences":[{"source":"PubMed","id":"22645314","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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