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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8RS0

Structure of RyR1 in detergent in primed state in complex with nanobody and FKBP

This is a non-PDB format compatible entry.

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	PHE4559-PHE4579
E	PHE4559-PHE4579
G	PHE4559-PHE4579
J	PHE4559-PHE4579

site_id	SWS_FT_FI2
Number of Residues	408
Details	TOPO_DOM: Lumenal => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	TYR4580-GLU4640
G	HIS4803
G	ASN4857-MET4879
G	GLU4900-THR4919
J	TYR4580-GLU4640
J	HIS4803
J	ASN4857-MET4879
J	GLU4900-THR4919
B	HIS4803
B	ASN4857-MET4879
B	GLU4900-THR4919
E	TYR4580-GLU4640
E	HIS4803
E	ASN4857-MET4879
E	GLU4900-THR4919
G	TYR4580-GLU4640

site_id	SWS_FT_FI3
Number of Residues	80
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	PRO4641-TYR4661
E	PRO4641-TYR4661
G	PRO4641-TYR4661
J	PRO4641-TYR4661

site_id	SWS_FT_FI4
Number of Residues	908
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	ASN4662-LYS4779
J	ASN4662-LYS4779
J	LYS4821-LYS4835
J	GLY4941-SER5037
B	LYS4821-LYS4835
B	GLY4941-SER5037
E	ASN4662-LYS4779
E	LYS4821-LYS4835
E	GLY4941-SER5037
G	ASN4662-LYS4779
G	LYS4821-LYS4835
G	GLY4941-SER5037

site_id	SWS_FT_FI5
Number of Residues	88
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	PHE4780-GLY4802
E	PHE4780-GLY4802
G	PHE4780-GLY4802
J	PHE4780-GLY4802

site_id	SWS_FT_FI6
Number of Residues	64
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	TYR4804-VAL4820
E	TYR4804-VAL4820
G	TYR4804-VAL4820
J	TYR4804-VAL4820

site_id	SWS_FT_FI7
Number of Residues	80
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	GLN4836-PHE4856
E	GLN4836-PHE4856
G	GLN4836-PHE4856
J	GLN4836-PHE4856

site_id	SWS_FT_FI8
Number of Residues	76
Details	INTRAMEM: Pore-forming => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	MET4880-ASP4899
E	MET4880-ASP4899
G	MET4880-ASP4899
J	MET4880-ASP4899

site_id	SWS_FT_FI9
Number of Residues	80
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
B	PHE4920-PHE4940
E	PHE4920-PHE4940
G	PHE4920-PHE4940
J	PHE4920-PHE4940

site_id	SWS_FT_FI10
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:27662087, ECO:0007744\|PDB:5TA3, ECO:0007744\|PDB:5TAL, ECO:0007744\|PDB:5TAM, ECO:0007744\|PDB:5TAN

Chain	Residue	Details
B	GLU3893
J	GLU3893
J	GLU3967
J	THR5001
B	GLU3967
B	THR5001
E	GLU3893
E	GLU3967
E	THR5001
G	GLU3893
G	GLU3967
G	THR5001

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:27662087, ECO:0007744\|PDB:5T9V, ECO:0007744\|PDB:5TA3, ECO:0007744\|PDB:5TAL, ECO:0007744\|PDB:5TAM, ECO:0007744\|PDB:5TAN, ECO:0007744\|PDB:5TAS, ECO:0007744\|PDB:5TAT, ECO:0007744\|PDB:5TAU

Chain	Residue	Details
B	LYS4211
J	LYS4211
J	MET4954
J	THR4979
B	MET4954
B	THR4979
E	LYS4211
E	MET4954
E	THR4979
G	LYS4211
G	MET4954
G	THR4979

site_id	SWS_FT_FI12
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:27662087, ECO:0007744\|PDB:5TAN

Chain	Residue	Details
B	TRP4716
E	TRP4716
G	TRP4716
J	TRP4716

site_id	SWS_FT_FI13
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:F1LMY4

Chain	Residue	Details
B	SER1338
J	SER1338
J	SER2345
J	SER4470
B	SER2345
B	SER4470
E	SER1338
E	SER2345
E	SER4470
G	SER1338
G	SER2345
G	SER4470

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA and PKG => ECO:0000269\|PubMed:8380342

Chain	Residue	Details
B	SER2843
E	SER2843
G	SER2843
J	SER2843

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000269\|PubMed:10601232, ECO:0000269\|PubMed:11562475, ECO:0000269\|PubMed:22036948

Chain	Residue	Details
B	CYS3635
E	CYS3635
G	CYS3635
J	CYS3635

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:F1LMY4

Chain	Residue	Details
B	THR4466
E	THR4466
G	THR4466
J	THR4466

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P21817

Chain	Residue	Details
B	TYR4863
E	TYR4863
G	TYR4863
J	TYR4863

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P21817

Chain	Residue	Details
B	SER4866
E	SER4866
G	SER4866
J	SER4866

227344

PDB entries from 2024-11-13

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