8RRS
Structure of mouse RyR2 solubilised in detergent in open state in complex with Ca2+, ATP, caffeine and Nb9657.
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17304 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ARG4231 | |
| A | GLY4870-ASN4966 | |
| C | MET1-ARG4231 | |
| C | GLY4870-ASN4966 | |
| E | MET1-ARG4231 | |
| E | GLY4870-ASN4966 | |
| F | MET1-ARG4231 | |
| F | GLY4870-ASN4966 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 560 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | MET4232-LEU4252 | |
| C | MET4502-THR4522 | |
| C | THR4579-PHE4599 | |
| C | VAL4729-PHE4749 | |
| C | LEU4768-PHE4788 | |
| C | PHE4849-PHE4869 | |
| E | MET4232-LEU4252 | |
| E | MET4278-ALA4298 | |
| E | MET4502-THR4522 | |
| E | THR4579-PHE4599 | |
| E | VAL4729-PHE4749 | |
| A | MET4278-ALA4298 | |
| E | LEU4768-PHE4788 | |
| E | PHE4849-PHE4869 | |
| F | MET4232-LEU4252 | |
| F | MET4278-ALA4298 | |
| F | MET4502-THR4522 | |
| F | THR4579-PHE4599 | |
| F | VAL4729-PHE4749 | |
| F | LEU4768-PHE4788 | |
| F | PHE4849-PHE4869 | |
| A | MET4502-THR4522 | |
| A | THR4579-PHE4599 | |
| A | VAL4729-PHE4749 | |
| A | LEU4768-PHE4788 | |
| A | PHE4849-PHE4869 | |
| C | MET4232-LEU4252 | |
| C | MET4278-ALA4298 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | INTRAMEM: Pore-forming => ECO:0000305 |
| Chain | Residue | Details |
| A | GLY4819-ASP4828 | |
| C | GLY4819-ASP4828 | |
| E | GLY4819-ASP4828 | |
| F | GLY4819-ASP4828 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER1341 | |
| C | SER2946 | |
| E | SER1341 | |
| E | SER2368 | |
| E | SER2796 | |
| E | SER2810 | |
| E | SER2946 | |
| F | SER1341 | |
| F | SER2368 | |
| F | SER2796 | |
| F | SER2810 | |
| A | SER2368 | |
| F | SER2946 | |
| A | SER2796 | |
| A | SER2810 | |
| A | SER2946 | |
| C | SER1341 | |
| C | SER2368 | |
| C | SER2796 | |
| C | SER2810 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:B0LPN4 |
| Chain | Residue | Details |
| A | SER1870 | |
| A | SER2696 | |
| C | SER1870 | |
| C | SER2696 | |
| E | SER1870 | |
| E | SER2696 | |
| F | SER1870 | |
| F | SER2696 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:17693412 |
| Chain | Residue | Details |
| A | SER2030 | |
| C | SER2030 | |
| E | SER2030 | |
| F | SER2030 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CaMK2D and PKA => ECO:0000269|PubMed:20431056, ECO:0000269|PubMed:21098440, ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER2807 | |
| C | SER2807 | |
| E | SER2807 | |
| F | SER2807 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CaMK2D => ECO:0000269|PubMed:21098440, ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER2813 | |
| C | SER2813 | |
| E | SER2813 | |
| F | SER2813 |
