8RRS

Structure of mouse RyR2 solubilised in detergent in open state in complex with Ca2+, ATP, caffeine and Nb9657.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0002027	biological_process	regulation of heart rate
A	0003143	biological_process	embryonic heart tube morphogenesis
A	0003220	biological_process	left ventricular cardiac muscle tissue morphogenesis
A	0003300	biological_process	cardiac muscle hypertrophy
A	0005216	molecular_function	monoatomic ion channel activity
A	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005513	biological_process	detection of calcium ion
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005635	cellular_component	nuclear envelope
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0006941	biological_process	striated muscle contraction
A	0010460	biological_process	positive regulation of heart rate
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
A	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0014850	biological_process	response to muscle activity
A	0015278	molecular_function	intracellularly gated calcium channel activity
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019722	biological_process	calcium-mediated signaling
A	0019899	molecular_function	enzyme binding
A	0019901	molecular_function	protein kinase binding
A	0030017	cellular_component	sarcomere
A	0030018	cellular_component	Z disc
A	0031000	biological_process	response to caffeine
A	0031234	cellular_component	extrinsic component of cytoplasmic side of plasma membrane
A	0031672	cellular_component	A band
A	0032026	biological_process	response to magnesium ion
A	0032991	cellular_component	protein-containing complex
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034236	molecular_function	protein kinase A catalytic subunit binding
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0034704	cellular_component	calcium channel complex
A	0035994	biological_process	response to muscle stretch
A	0042383	cellular_component	sarcolemma
A	0042802	molecular_function	identical protein binding
A	0043924	molecular_function	suramin binding
A	0048763	molecular_function	calcium-induced calcium release activity
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051284	biological_process	positive regulation of sequestering of calcium ion
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0051481	biological_process	negative regulation of cytosolic calcium ion concentration
A	0051592	biological_process	response to calcium ion
A	0051775	biological_process	response to redox state
A	0055085	biological_process	transmembrane transport
A	0055117	biological_process	regulation of cardiac muscle contraction
A	0060048	biological_process	cardiac muscle contraction
A	0060402	biological_process	calcium ion transport into cytosol
A	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071313	biological_process	cellular response to caffeine
A	0071421	biological_process	manganese ion transmembrane transport
A	0071872	biological_process	cellular response to epinephrine stimulus
A	0072599	biological_process	establishment of protein localization to endoplasmic reticulum
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	0086029	biological_process	Purkinje myocyte to ventricular cardiac muscle cell signaling
A	0097050	biological_process	type B pancreatic cell apoptotic process
A	0097110	molecular_function	scaffold protein binding
A	0097553	biological_process	calcium ion transmembrane import into cytosol
A	0098735	biological_process	positive regulation of the force of heart contraction
A	0098904	biological_process	regulation of AV node cell action potential
A	0098907	biological_process	regulation of SA node cell action potential
A	0098910	biological_process	regulation of atrial cardiac muscle cell action potential
A	0098911	biological_process	regulation of ventricular cardiac muscle cell action potential
C	0001666	biological_process	response to hypoxia
C	0002027	biological_process	regulation of heart rate
C	0003143	biological_process	embryonic heart tube morphogenesis
C	0003220	biological_process	left ventricular cardiac muscle tissue morphogenesis
C	0003300	biological_process	cardiac muscle hypertrophy
C	0005216	molecular_function	monoatomic ion channel activity
C	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
C	0005262	molecular_function	calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005635	cellular_component	nuclear envelope
C	0005790	cellular_component	smooth endoplasmic reticulum
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0006941	biological_process	striated muscle contraction
C	0010460	biological_process	positive regulation of heart rate
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
C	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0014850	biological_process	response to muscle activity
C	0015278	molecular_function	intracellularly gated calcium channel activity
C	0016020	cellular_component	membrane
C	0016529	cellular_component	sarcoplasmic reticulum
C	0019722	biological_process	calcium-mediated signaling
C	0019899	molecular_function	enzyme binding
C	0019901	molecular_function	protein kinase binding
C	0030017	cellular_component	sarcomere
C	0030018	cellular_component	Z disc
C	0031000	biological_process	response to caffeine
C	0031234	cellular_component	extrinsic component of cytoplasmic side of plasma membrane
C	0031672	cellular_component	A band
C	0032026	biological_process	response to magnesium ion
C	0032991	cellular_component	protein-containing complex
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034236	molecular_function	protein kinase A catalytic subunit binding
C	0034237	molecular_function	protein kinase A regulatory subunit binding
C	0034704	cellular_component	calcium channel complex
C	0035994	biological_process	response to muscle stretch
C	0042383	cellular_component	sarcolemma
C	0042802	molecular_function	identical protein binding
C	0043924	molecular_function	suramin binding
C	0048763	molecular_function	calcium-induced calcium release activity
C	0051209	biological_process	release of sequestered calcium ion into cytosol
C	0051284	biological_process	positive regulation of sequestering of calcium ion
C	0051480	biological_process	regulation of cytosolic calcium ion concentration
C	0051481	biological_process	negative regulation of cytosolic calcium ion concentration
C	0051592	biological_process	response to calcium ion
C	0051775	biological_process	response to redox state
C	0055085	biological_process	transmembrane transport
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060048	biological_process	cardiac muscle contraction
C	0060402	biological_process	calcium ion transport into cytosol
C	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0071313	biological_process	cellular response to caffeine
C	0071421	biological_process	manganese ion transmembrane transport
C	0071872	biological_process	cellular response to epinephrine stimulus
C	0072599	biological_process	establishment of protein localization to endoplasmic reticulum
C	0086005	biological_process	ventricular cardiac muscle cell action potential
C	0086029	biological_process	Purkinje myocyte to ventricular cardiac muscle cell signaling
C	0097050	biological_process	type B pancreatic cell apoptotic process
C	0097110	molecular_function	scaffold protein binding
C	0097553	biological_process	calcium ion transmembrane import into cytosol
C	0098735	biological_process	positive regulation of the force of heart contraction
C	0098904	biological_process	regulation of AV node cell action potential
C	0098907	biological_process	regulation of SA node cell action potential
C	0098910	biological_process	regulation of atrial cardiac muscle cell action potential
C	0098911	biological_process	regulation of ventricular cardiac muscle cell action potential
E	0001666	biological_process	response to hypoxia
E	0002027	biological_process	regulation of heart rate
E	0003143	biological_process	embryonic heart tube morphogenesis
E	0003220	biological_process	left ventricular cardiac muscle tissue morphogenesis
E	0003300	biological_process	cardiac muscle hypertrophy
E	0005216	molecular_function	monoatomic ion channel activity
E	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
E	0005262	molecular_function	calcium channel activity
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005516	molecular_function	calmodulin binding
E	0005635	cellular_component	nuclear envelope
E	0005790	cellular_component	smooth endoplasmic reticulum
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0006941	biological_process	striated muscle contraction
E	0010460	biological_process	positive regulation of heart rate
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
E	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0014850	biological_process	response to muscle activity
E	0015278	molecular_function	intracellularly gated calcium channel activity
E	0016020	cellular_component	membrane
E	0016529	cellular_component	sarcoplasmic reticulum
E	0019722	biological_process	calcium-mediated signaling
E	0019899	molecular_function	enzyme binding
E	0019901	molecular_function	protein kinase binding
E	0030017	cellular_component	sarcomere
E	0030018	cellular_component	Z disc
E	0031000	biological_process	response to caffeine
E	0031234	cellular_component	extrinsic component of cytoplasmic side of plasma membrane
E	0031672	cellular_component	A band
E	0032026	biological_process	response to magnesium ion
E	0032991	cellular_component	protein-containing complex
E	0033017	cellular_component	sarcoplasmic reticulum membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034236	molecular_function	protein kinase A catalytic subunit binding
E	0034237	molecular_function	protein kinase A regulatory subunit binding
E	0034704	cellular_component	calcium channel complex
E	0035994	biological_process	response to muscle stretch
E	0042383	cellular_component	sarcolemma
E	0042802	molecular_function	identical protein binding
E	0043924	molecular_function	suramin binding
E	0048763	molecular_function	calcium-induced calcium release activity
E	0051209	biological_process	release of sequestered calcium ion into cytosol
E	0051284	biological_process	positive regulation of sequestering of calcium ion
E	0051480	biological_process	regulation of cytosolic calcium ion concentration
E	0051481	biological_process	negative regulation of cytosolic calcium ion concentration
E	0051592	biological_process	response to calcium ion
E	0051775	biological_process	response to redox state
E	0055085	biological_process	transmembrane transport
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060048	biological_process	cardiac muscle contraction
E	0060402	biological_process	calcium ion transport into cytosol
E	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
E	0070588	biological_process	calcium ion transmembrane transport
E	0071313	biological_process	cellular response to caffeine
E	0071421	biological_process	manganese ion transmembrane transport
E	0071872	biological_process	cellular response to epinephrine stimulus
E	0072599	biological_process	establishment of protein localization to endoplasmic reticulum
E	0086005	biological_process	ventricular cardiac muscle cell action potential
E	0086029	biological_process	Purkinje myocyte to ventricular cardiac muscle cell signaling
E	0097050	biological_process	type B pancreatic cell apoptotic process
E	0097110	molecular_function	scaffold protein binding
E	0097553	biological_process	calcium ion transmembrane import into cytosol
E	0098735	biological_process	positive regulation of the force of heart contraction
E	0098904	biological_process	regulation of AV node cell action potential
E	0098907	biological_process	regulation of SA node cell action potential
E	0098910	biological_process	regulation of atrial cardiac muscle cell action potential
E	0098911	biological_process	regulation of ventricular cardiac muscle cell action potential
F	0001666	biological_process	response to hypoxia
F	0002027	biological_process	regulation of heart rate
F	0003143	biological_process	embryonic heart tube morphogenesis
F	0003220	biological_process	left ventricular cardiac muscle tissue morphogenesis
F	0003300	biological_process	cardiac muscle hypertrophy
F	0005216	molecular_function	monoatomic ion channel activity
F	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
F	0005262	molecular_function	calcium channel activity
F	0005509	molecular_function	calcium ion binding
F	0005513	biological_process	detection of calcium ion
F	0005515	molecular_function	protein binding
F	0005516	molecular_function	calmodulin binding
F	0005635	cellular_component	nuclear envelope
F	0005790	cellular_component	smooth endoplasmic reticulum
F	0006811	biological_process	monoatomic ion transport
F	0006816	biological_process	calcium ion transport
F	0006874	biological_process	intracellular calcium ion homeostasis
F	0006941	biological_process	striated muscle contraction
F	0010460	biological_process	positive regulation of heart rate
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
F	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0014850	biological_process	response to muscle activity
F	0015278	molecular_function	intracellularly gated calcium channel activity
F	0016020	cellular_component	membrane
F	0016529	cellular_component	sarcoplasmic reticulum
F	0019722	biological_process	calcium-mediated signaling
F	0019899	molecular_function	enzyme binding
F	0019901	molecular_function	protein kinase binding
F	0030017	cellular_component	sarcomere
F	0030018	cellular_component	Z disc
F	0031000	biological_process	response to caffeine
F	0031234	cellular_component	extrinsic component of cytoplasmic side of plasma membrane
F	0031672	cellular_component	A band
F	0032026	biological_process	response to magnesium ion
F	0032991	cellular_component	protein-containing complex
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034236	molecular_function	protein kinase A catalytic subunit binding
F	0034237	molecular_function	protein kinase A regulatory subunit binding
F	0034704	cellular_component	calcium channel complex
F	0035994	biological_process	response to muscle stretch
F	0042383	cellular_component	sarcolemma
F	0042802	molecular_function	identical protein binding
F	0043924	molecular_function	suramin binding
F	0048763	molecular_function	calcium-induced calcium release activity
F	0051209	biological_process	release of sequestered calcium ion into cytosol
F	0051284	biological_process	positive regulation of sequestering of calcium ion
F	0051480	biological_process	regulation of cytosolic calcium ion concentration
F	0051481	biological_process	negative regulation of cytosolic calcium ion concentration
F	0051592	biological_process	response to calcium ion
F	0051775	biological_process	response to redox state
F	0055085	biological_process	transmembrane transport
F	0055117	biological_process	regulation of cardiac muscle contraction
F	0060048	biological_process	cardiac muscle contraction
F	0060402	biological_process	calcium ion transport into cytosol
F	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
F	0070588	biological_process	calcium ion transmembrane transport
F	0071313	biological_process	cellular response to caffeine
F	0071421	biological_process	manganese ion transmembrane transport
F	0071872	biological_process	cellular response to epinephrine stimulus
F	0072599	biological_process	establishment of protein localization to endoplasmic reticulum
F	0086005	biological_process	ventricular cardiac muscle cell action potential
F	0086029	biological_process	Purkinje myocyte to ventricular cardiac muscle cell signaling
F	0097050	biological_process	type B pancreatic cell apoptotic process
F	0097110	molecular_function	scaffold protein binding
F	0097553	biological_process	calcium ion transmembrane import into cytosol
F	0098735	biological_process	positive regulation of the force of heart contraction
F	0098904	biological_process	regulation of AV node cell action potential
F	0098907	biological_process	regulation of SA node cell action potential
F	0098910	biological_process	regulation of atrial cardiac muscle cell action potential
F	0098911	biological_process	regulation of ventricular cardiac muscle cell action potential

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	220
Details	Domain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	180
Details	Domain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	220
Details	Domain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	228
Details	Domain: {"description":"MIR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	840
Details	Domain: {"description":"B30.2/SPRY 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00548","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---