8RHN

Structure of the 55LCC ATPase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0042254	biological_process	ribosome biogenesis
A	0042273	biological_process	ribosomal large subunit biogenesis
A	0090069	biological_process	regulation of ribosome biogenesis
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0042254	biological_process	ribosome biogenesis
B	0042273	biological_process	ribosomal large subunit biogenesis
B	0090069	biological_process	regulation of ribosome biogenesis
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0042254	biological_process	ribosome biogenesis
C	0042273	biological_process	ribosomal large subunit biogenesis
C	0051301	biological_process	cell division
C	0090069	biological_process	regulation of ribosome biogenesis
C	1990275	molecular_function	preribosome binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0042254	biological_process	ribosome biogenesis
D	0042273	biological_process	ribosomal large subunit biogenesis
D	0051301	biological_process	cell division
D	0090069	biological_process	regulation of ribosome biogenesis
D	1990275	molecular_function	preribosome binding
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0007283	biological_process	spermatogenesis
E	0007420	biological_process	brain development
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030154	biological_process	cell differentiation
E	0042254	biological_process	ribosome biogenesis
E	0042273	biological_process	ribosomal large subunit biogenesis
E	0044877	molecular_function	protein-containing complex binding
E	0090069	biological_process	regulation of ribosome biogenesis
E	1990275	molecular_function	preribosome binding
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0007283	biological_process	spermatogenesis
F	0007420	biological_process	brain development
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0030154	biological_process	cell differentiation
F	0042254	biological_process	ribosome biogenesis
F	0042273	biological_process	ribosomal large subunit biogenesis
F	0044877	molecular_function	protein-containing complex binding
F	0090069	biological_process	regulation of ribosome biogenesis
F	1990275	molecular_function	preribosome binding
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0007283	biological_process	spermatogenesis
G	0007420	biological_process	brain development
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0030154	biological_process	cell differentiation
G	0042254	biological_process	ribosome biogenesis
G	0042273	biological_process	ribosomal large subunit biogenesis
G	0044877	molecular_function	protein-containing complex binding
G	0090069	biological_process	regulation of ribosome biogenesis
G	1990275	molecular_function	preribosome binding
H	0000166	molecular_function	nucleotide binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0006260	biological_process	DNA replication
H	0007283	biological_process	spermatogenesis
H	0007420	biological_process	brain development
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0030154	biological_process	cell differentiation
H	0042254	biological_process	ribosome biogenesis
H	0042273	biological_process	ribosomal large subunit biogenesis
H	0044877	molecular_function	protein-containing complex binding
H	0090069	biological_process	regulation of ribosome biogenesis
H	1990275	molecular_function	preribosome binding
I	0000166	molecular_function	nucleotide binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005819	cellular_component	spindle
I	0005829	cellular_component	cytosol
I	0006260	biological_process	DNA replication
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0030970	biological_process	retrograde protein transport, ER to cytosol
I	0031593	molecular_function	polyubiquitin modification-dependent protein binding
I	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
I	0042254	biological_process	ribosome biogenesis
I	0042273	biological_process	ribosomal large subunit biogenesis
I	0042802	molecular_function	identical protein binding
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0044877	molecular_function	protein-containing complex binding
I	0051228	biological_process	mitotic spindle disassembly
I	0090069	biological_process	regulation of ribosome biogenesis
I	0097352	biological_process	autophagosome maturation
I	1990275	molecular_function	preribosome binding
J	0000166	molecular_function	nucleotide binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005819	cellular_component	spindle
J	0005829	cellular_component	cytosol
J	0006260	biological_process	DNA replication
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0030970	biological_process	retrograde protein transport, ER to cytosol
J	0031593	molecular_function	polyubiquitin modification-dependent protein binding
J	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
J	0042254	biological_process	ribosome biogenesis
J	0042273	biological_process	ribosomal large subunit biogenesis
J	0042802	molecular_function	identical protein binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0044877	molecular_function	protein-containing complex binding
J	0051228	biological_process	mitotic spindle disassembly
J	0090069	biological_process	regulation of ribosome biogenesis
J	0097352	biological_process	autophagosome maturation
J	1990275	molecular_function	preribosome binding
K	0000166	molecular_function	nucleotide binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0006260	biological_process	DNA replication
K	0007283	biological_process	spermatogenesis
K	0007420	biological_process	brain development
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0030154	biological_process	cell differentiation
K	0042254	biological_process	ribosome biogenesis
K	0042273	biological_process	ribosomal large subunit biogenesis
K	0044877	molecular_function	protein-containing complex binding
K	0090069	biological_process	regulation of ribosome biogenesis
K	1990275	molecular_function	preribosome binding
L	0000166	molecular_function	nucleotide binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005819	cellular_component	spindle
L	0005829	cellular_component	cytosol
L	0006260	biological_process	DNA replication
L	0007283	biological_process	spermatogenesis
L	0007420	biological_process	brain development
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0030154	biological_process	cell differentiation
L	0042254	biological_process	ribosome biogenesis
L	0042273	biological_process	ribosomal large subunit biogenesis
L	0044877	molecular_function	protein-containing complex binding
L	0090069	biological_process	regulation of ribosome biogenesis
L	1990275	molecular_function	preribosome binding
M	0000166	molecular_function	nucleotide binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005819	cellular_component	spindle
M	0005829	cellular_component	cytosol
M	0006260	biological_process	DNA replication
M	0007283	biological_process	spermatogenesis
M	0007420	biological_process	brain development
M	0016787	molecular_function	hydrolase activity
M	0016887	molecular_function	ATP hydrolysis activity
M	0030154	biological_process	cell differentiation
M	0042254	biological_process	ribosome biogenesis
M	0042273	biological_process	ribosomal large subunit biogenesis
M	0044877	molecular_function	protein-containing complex binding
M	0090069	biological_process	regulation of ribosome biogenesis
M	1990275	molecular_function	preribosome binding
N	0000166	molecular_function	nucleotide binding
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005819	cellular_component	spindle
N	0005829	cellular_component	cytosol
N	0006260	biological_process	DNA replication
N	0007283	biological_process	spermatogenesis
N	0007420	biological_process	brain development
N	0016787	molecular_function	hydrolase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0030154	biological_process	cell differentiation
N	0042254	biological_process	ribosome biogenesis
N	0042273	biological_process	ribosomal large subunit biogenesis
N	0044877	molecular_function	protein-containing complex binding
N	0090069	biological_process	regulation of ribosome biogenesis
N	1990275	molecular_function	preribosome binding
O	0000166	molecular_function	nucleotide binding
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0006260	biological_process	DNA replication
O	0016787	molecular_function	hydrolase activity
O	0016887	molecular_function	ATP hydrolysis activity
O	0030970	biological_process	retrograde protein transport, ER to cytosol
O	0031593	molecular_function	polyubiquitin modification-dependent protein binding
O	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
O	0042254	biological_process	ribosome biogenesis
O	0042273	biological_process	ribosomal large subunit biogenesis
O	0042802	molecular_function	identical protein binding
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0044877	molecular_function	protein-containing complex binding
O	0051228	biological_process	mitotic spindle disassembly
O	0090069	biological_process	regulation of ribosome biogenesis
O	0097352	biological_process	autophagosome maturation
O	1990275	molecular_function	preribosome binding
P	0000166	molecular_function	nucleotide binding
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005819	cellular_component	spindle
P	0005829	cellular_component	cytosol
P	0006260	biological_process	DNA replication
P	0016787	molecular_function	hydrolase activity
P	0016887	molecular_function	ATP hydrolysis activity
P	0030970	biological_process	retrograde protein transport, ER to cytosol
P	0031593	molecular_function	polyubiquitin modification-dependent protein binding
P	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
P	0042254	biological_process	ribosome biogenesis
P	0042273	biological_process	ribosomal large subunit biogenesis
P	0042802	molecular_function	identical protein binding
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0044877	molecular_function	protein-containing complex binding
P	0051228	biological_process	mitotic spindle disassembly
P	0090069	biological_process	regulation of ribosome biogenesis
P	0097352	biological_process	autophagosome maturation
P	1990275	molecular_function	preribosome binding

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VlVLgATNrphaLDaALr.R

Chain	Residue	Details
K	VAL493-ARG511
K	VAL766-ARG784
O	VAL338-ARG356
O	VAL622-ARG640

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P32794","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38554706","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---