8RDZ
Crystal Structure of Human ADP-ribose Pyrophosphatase NUDT5 In complex with Ibrutinib
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GliddgEtpeaAAlRELeEEtG |
| Chain | Residue | Details |
| A | GLY97-GLY118 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755, ECO:0000269|PubMed:21768126 |
| Chain | Residue | Details |
| A | TRP28 | |
| A | ARG84 | |
| B | TRP28 | |
| B | ARG84 | |
| C | TRP28 | |
| C | ARG84 | |
| D | TRP28 | |
| D | ARG84 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:18462755, ECO:0000269|PubMed:21768126 |
| Chain | Residue | Details |
| A | TRP46 | |
| A | ARG51 | |
| A | ALA96 | |
| A | GLU112 | |
| A | GLU116 | |
| A | GLU166 | |
| B | TRP46 | |
| B | ARG51 | |
| B | ALA96 | |
| B | GLU112 | |
| B | GLU116 | |
| B | GLU166 | |
| C | TRP46 | |
| C | ARG51 | |
| C | ALA96 | |
| C | GLU112 | |
| C | GLU116 | |
| C | GLU166 | |
| D | TRP46 | |
| D | ARG51 | |
| D | ALA96 | |
| D | GLU112 | |
| D | GLU116 | |
| D | GLU166 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:17052728 |
| Chain | Residue | Details |
| A | LEU98 | |
| A | ASP133 | |
| B | LEU98 | |
| B | ASP133 | |
| C | LEU98 | |
| C | ASP133 | |
| D | LEU98 | |
| D | ASP133 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 | |
| C | MET1 | |
| D | MET1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER3 | |
| B | SER3 | |
| C | SER3 | |
| D | SER3 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER10 | |
| B | SER10 | |
| C | SER10 | |
| D | SER10 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:27257257 |
| Chain | Residue | Details |
| A | THR45 | |
| B | THR45 | |
| C | THR45 | |
| D | THR45 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR74 | |
| B | TYR74 | |
| C | TYR74 | |
| D | TYR74 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS210 | |
| A | LYS218 | |
| B | LYS210 | |
| B | LYS218 | |
| C | LYS210 | |
| C | LYS218 | |
| D | LYS210 | |
| D | LYS218 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS42 | |
| B | LYS42 | |
| C | LYS42 | |
| D | LYS42 |
