8RD4

Telomeric RAP1:DNA-PK complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000460	biological_process	maturation of 5.8S rRNA
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005730	cellular_component	nucleolus
A	0005829	cellular_component	cytosol
A	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0016020	cellular_component	membrane
A	0016233	biological_process	telomere capping
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0032040	cellular_component	small-subunit processome
A	0032869	biological_process	cellular response to insulin stimulus
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0033152	biological_process	immunoglobulin V(D)J recombination
A	0034462	biological_process	small-subunit processome assembly
A	0034511	molecular_function	U3 snoRNA binding
A	0035979	molecular_function	histone H2AXS139 kinase activity
A	0036211	biological_process	protein modification process
A	0042254	biological_process	ribosome biogenesis
A	0042752	biological_process	regulation of circadian rhythm
A	0043066	biological_process	negative regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045727	biological_process	positive regulation of translation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048511	biological_process	rhythmic process
A	0048660	biological_process	regulation of smooth muscle cell proliferation
A	0050678	biological_process	regulation of epithelial cell proliferation
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070419	cellular_component	nonhomologous end joining complex
A	0080135	biological_process	regulation of cellular response to stress
A	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
A	0106310	molecular_function	protein serine kinase activity
A	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
A	1902036	biological_process	regulation of hematopoietic stem cell differentiation
A	1905221	biological_process	positive regulation of platelet formation
A	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
D	0000228	cellular_component	nuclear chromosome
D	0000723	biological_process	telomere maintenance
D	0000781	cellular_component	chromosome, telomeric region
D	0000783	cellular_component	nuclear telomere cap complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0006351	biological_process	DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription
D	0007004	biological_process	telomere maintenance via telomerase
D	0010569	biological_process	regulation of double-strand break repair via homologous recombination
D	0010833	biological_process	telomere maintenance via telomere lengthening
D	0016233	biological_process	telomere capping
D	0019902	molecular_function	phosphatase binding
D	0031848	biological_process	protection from non-homologous end joining at telomere
D	0032204	biological_process	regulation of telomere maintenance
D	0032205	biological_process	negative regulation of telomere maintenance
D	0032206	biological_process	positive regulation of telomere maintenance
D	0035556	biological_process	intracellular signal transduction
D	0042162	molecular_function	telomeric DNA binding
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0048239	biological_process	negative regulation of DNA recombination at telomere
D	0070187	cellular_component	shelterin complex
D	0070198	biological_process	protein localization to chromosome, telomeric region
D	0098505	molecular_function	G-rich strand telomeric DNA binding
E	0000166	molecular_function	nucleotide binding
E	0000723	biological_process	telomere maintenance
E	0000725	biological_process	recombinational repair
E	0000781	cellular_component	chromosome, telomeric region
E	0000783	cellular_component	nuclear telomere cap complex
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0002218	biological_process	activation of innate immune response
E	0002376	biological_process	immune system process
E	0002684	biological_process	positive regulation of immune system process
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0003684	molecular_function	damaged DNA binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003691	molecular_function	double-stranded telomeric DNA binding
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005667	cellular_component	transcription regulator complex
E	0005694	cellular_component	chromosome
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
E	0006281	biological_process	DNA repair
E	0006303	biological_process	double-strand break repair via nonhomologous end joining
E	0006310	biological_process	DNA recombination
E	0006351	biological_process	DNA-templated transcription
E	0006974	biological_process	DNA damage response
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0010212	biological_process	response to ionizing radiation
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016829	molecular_function	lyase activity
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030332	molecular_function	cyclin binding
E	0032991	cellular_component	protein-containing complex
E	0032993	cellular_component	protein-DNA complex
E	0034774	cellular_component	secretory granule lumen
E	0042162	molecular_function	telomeric DNA binding
E	0043138	molecular_function	3'-5' DNA helicase activity
E	0043564	cellular_component	Ku70:Ku80 complex
E	0044877	molecular_function	protein-containing complex binding
E	0045027	molecular_function	DNA end binding
E	0045087	biological_process	innate immune response
E	0045621	biological_process	positive regulation of lymphocyte differentiation
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0048660	biological_process	regulation of smooth muscle cell proliferation
E	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
E	0070419	cellular_component	nonhomologous end joining complex
E	0071475	biological_process	cellular hyperosmotic salinity response
E	0071480	biological_process	cellular response to gamma radiation
E	0071481	biological_process	cellular response to X-ray
E	0097110	molecular_function	scaffold protein binding
E	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
E	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000166	molecular_function	nucleotide binding
F	0000723	biological_process	telomere maintenance
F	0000725	biological_process	recombinational repair
F	0000781	cellular_component	chromosome, telomeric region
F	0000783	cellular_component	nuclear telomere cap complex
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0002218	biological_process	activation of innate immune response
F	0002376	biological_process	immune system process
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0003684	molecular_function	damaged DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003691	molecular_function	double-stranded telomeric DNA binding
F	0003723	molecular_function	RNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
F	0006281	biological_process	DNA repair
F	0006302	biological_process	double-strand break repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0006351	biological_process	DNA-templated transcription
F	0006974	biological_process	DNA damage response
F	0007004	biological_process	telomere maintenance via telomerase
F	0008047	molecular_function	enzyme activator activity
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0016829	molecular_function	lyase activity
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032040	cellular_component	small-subunit processome
F	0032204	biological_process	regulation of telomere maintenance
F	0032991	cellular_component	protein-containing complex
F	0032993	cellular_component	protein-DNA complex
F	0034462	biological_process	small-subunit processome assembly
F	0034511	molecular_function	U3 snoRNA binding
F	0034774	cellular_component	secretory granule lumen
F	0042162	molecular_function	telomeric DNA binding
F	0042254	biological_process	ribosome biogenesis
F	0043138	molecular_function	3'-5' DNA helicase activity
F	0043564	cellular_component	Ku70:Ku80 complex
F	0044877	molecular_function	protein-containing complex binding
F	0045027	molecular_function	DNA end binding
F	0045087	biological_process	innate immune response
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0048660	biological_process	regulation of smooth muscle cell proliferation
F	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
F	0070198	biological_process	protein localization to chromosome, telomeric region
F	0070419	cellular_component	nonhomologous end joining complex
F	0071480	biological_process	cellular response to gamma radiation
F	0090734	cellular_component	site of DNA damage
F	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F	1904430	biological_process	negative regulation of t-circle formation
F	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ

Chain	Residue	Details
A	VAL3752-GLN3766

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN

Chain	Residue	Details
A	SER3907-ASN3927

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	33
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	33
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	331
Details	Domain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	32
Details	Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	62
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	25
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	15
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	23
Details	Domain: {"description":"BRCT"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	207
Details	Domain: {"description":"Ku"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	34
Details	Domain: {"description":"SAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00186","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	64
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	109
Details	Region: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	5
Details	Region: {"description":"Interaction with BAX","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Active site: {"description":"Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"35545041","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	222
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	199
Details	Domain: {"description":"Ku","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---