8R8R
Cryo-EM structure of the human mPSF with PAPOA C-terminus peptide (PAPOAc)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| A | 0006397 | biological_process | mRNA processing |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0035925 | molecular_function | mRNA 3'-UTR AU-rich region binding |
| A | 0180012 | biological_process | co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway |
| B | 0031124 | biological_process | mRNA 3'-end processing |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| C | 0006397 | biological_process | mRNA processing |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0046872 | molecular_function | metal ion binding |
| C | 1990837 | molecular_function | sequence-specific double-stranded DNA binding |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 13 |
| Details | LIPOCALIN Lipocalin signature. EVKl.NLNGNWLLT |
| Chain | Residue | Details |
| B | GLU293-THR305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P25500 |
| Chain | Residue | Details |
| D | LYS736 | |
| D | LYS740 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| D | SER738 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate => ECO:0000250 |
| Chain | Residue | Details |
| D | LYS736 | |
| D | LYS740 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | ZN_FING: C3H1-type 4 => ECO:0000255|PROSITE-ProRule:PRU00723 |
| Chain | Residue | Details |
| C | GLU118-HIS142 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | ZN_FING: C3H1-type 5 => ECO:0000255|PROSITE-ProRule:PRU00723 |
| Chain | Residue | Details |
| C | THR143-PHE169 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | MET200 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| C | SER202 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | PRO212 |
