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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8R7L

Cryo-EM structure of the human TREX complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000346cellular_componenttranscription export complex
A0000347cellular_componentTHO complex
A0000445cellular_componentTHO complex part of transcription export complex
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0006351biological_processDNA-templated transcription
A0006397biological_processmRNA processing
A0006406biological_processmRNA export from nucleus
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0008380biological_processRNA splicing
A0016363cellular_componentnuclear matrix
A0016607cellular_componentnuclear speck
A0042802molecular_functionidentical protein binding
A0051028biological_processmRNA transport
B0000346cellular_componenttranscription export complex
B0000347cellular_componentTHO complex
B0000445cellular_componentTHO complex part of transcription export complex
B0000781cellular_componentchromosome, telomeric region
B0003723molecular_functionRNA binding
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0006397biological_processmRNA processing
B0006406biological_processmRNA export from nucleus
B0008380biological_processRNA splicing
B0010977biological_processnegative regulation of neuron projection development
B0016607cellular_componentnuclear speck
B0016973biological_processpoly(A)+ mRNA export from nucleus
B0048666biological_processneuron development
B0048699biological_processgeneration of neurons
B0051028biological_processmRNA transport
C0000346cellular_componenttranscription export complex
C0000445cellular_componentTHO complex part of transcription export complex
C0000781cellular_componentchromosome, telomeric region
C0003723molecular_functionRNA binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0006397biological_processmRNA processing
C0006406biological_processmRNA export from nucleus
C0008380biological_processRNA splicing
C0016607cellular_componentnuclear speck
C0051028biological_processmRNA transport
D0003676molecular_functionnucleic acid binding
D0003723molecular_functionRNA binding
H0000166molecular_functionnucleotide binding
H0000245biological_processspliceosomal complex assembly
H0000346cellular_componenttranscription export complex
H0000398biological_processmRNA splicing, via spliceosome
H0003676molecular_functionnucleic acid binding
H0003723molecular_functionRNA binding
H0003724molecular_functionRNA helicase activity
H0003729molecular_functionmRNA binding
H0004386molecular_functionhelicase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005681cellular_componentspliceosomal complex
H0005687cellular_componentU4 snRNP
H0005688cellular_componentU6 snRNP
H0005737cellular_componentcytoplasm
H0006397biological_processmRNA processing
H0006405biological_processRNA export from nucleus
H0006406biological_processmRNA export from nucleus
H0008186molecular_functionATP-dependent activity, acting on RNA
H0008380biological_processRNA splicing
H0016607cellular_componentnuclear speck
H0016787molecular_functionhydrolase activity
H0016887molecular_functionATP hydrolysis activity
H0017070molecular_functionU6 snRNA binding
H0030621molecular_functionU4 snRNA binding
H0042802molecular_functionidentical protein binding
H0043008molecular_functionATP-dependent protein binding
H0051028biological_processmRNA transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues161
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsMotif: {"description":"DECD box"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues34
DetailsRegion: {"description":"Dock domain; interaction with THOC2","evidences":[{"source":"PubMed","id":"33191911","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues41
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues39
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues41
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues39
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues39
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PDB","id":"7APK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsRegion: {"description":"N-terminal UAP56-binding motif","evidences":[{"source":"PubMed","id":"37020021","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2004","submissionDatabase":"UniProtKB","authors":["Quadroni M."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-01-21

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