8R65

1918 H1N1 Viral polymerase heterotrimer in complex with 4 repeat serine-5 phosphorylated PolII peptide with ordered PB2 C-terminal domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004519	molecular_function	endonuclease activity
A	0006351	biological_process	DNA-templated transcription
A	0030430	cellular_component	host cell cytoplasm
A	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
A	0042025	cellular_component	host cell nucleus
A	0046872	molecular_function	metal ion binding
A	0075526	biological_process	cap snatching
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0006351	biological_process	DNA-templated transcription
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
B	0039694	biological_process	viral RNA genome replication
B	0042025	cellular_component	host cell nucleus
C	0001172	biological_process	RNA-templated transcription
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0006370	biological_process	7-methylguanosine mRNA capping
C	0019049	biological_process	virus-mediated perturbation of host defense response
C	0019083	biological_process	viral transcription
C	0033650	cellular_component	host cell mitochondrion
C	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
C	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
C	0042025	cellular_component	host cell nucleus
C	0044423	cellular_component	virion component
C	0075526	biological_process	cap snatching

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
X	TYR1-SER7
X	TYR8-SER14
X	TYR15-SER21
X	TYR22-SER28

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Mammalian adaptation => ECO:0000255|HAMAP-Rule:MF_04062

Chain	Residue	Details
C	LYS627
A	GLU80
A	ALA108
A	GLU119
A	ILE120

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