8R64

Cryo-EM structure of the FIGNL1 AAA hexamer bound to RAD51

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
D	0005524	molecular_function	ATP binding
D	0016887	molecular_function	ATP hydrolysis activity
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
F	0005524	molecular_function	ATP binding
F	0016887	molecular_function	ATP hydrolysis activity
G	0000150	molecular_function	DNA strand exchange activity
G	0000166	molecular_function	nucleotide binding
G	0000228	cellular_component	nuclear chromosome
G	0000722	biological_process	telomere maintenance via recombination
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0000730	biological_process	DNA recombinase assembly
G	0000781	cellular_component	chromosome, telomeric region
G	0000785	cellular_component	chromatin
G	0000793	cellular_component	condensed chromosome
G	0000794	cellular_component	condensed nuclear chromosome
G	0000800	cellular_component	lateral element
G	0003677	molecular_function	DNA binding
G	0003682	molecular_function	chromatin binding
G	0003690	molecular_function	double-stranded DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006259	biological_process	DNA metabolic process
G	0006281	biological_process	DNA repair
G	0006310	biological_process	DNA recombination
G	0006312	biological_process	mitotic recombination
G	0006974	biological_process	DNA damage response
G	0007127	biological_process	meiosis I
G	0007131	biological_process	reciprocal meiotic recombination
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0009410	biological_process	response to xenobiotic stimulus
G	0009636	biological_process	response to toxic substance
G	0010165	biological_process	response to X-ray
G	0010569	biological_process	regulation of double-strand break repair via homologous recombination
G	0010833	biological_process	telomere maintenance via telomere lengthening
G	0016605	cellular_component	PML body
G	0016787	molecular_function	hydrolase activity
G	0017116	molecular_function	single-stranded DNA helicase activity
G	0019899	molecular_function	enzyme binding
G	0031297	biological_process	replication fork processing
G	0032991	cellular_component	protein-containing complex
G	0032993	cellular_component	protein-DNA complex
G	0035861	cellular_component	site of double-strand break
G	0036297	biological_process	interstrand cross-link repair
G	0042148	biological_process	DNA strand invasion
G	0042802	molecular_function	identical protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0051321	biological_process	meiotic cell cycle
G	0070182	molecular_function	DNA polymerase binding
G	0070192	biological_process	chromosome organization involved in meiotic cell cycle
G	0071479	biological_process	cellular response to ionizing radiation
G	0071480	biological_process	cellular response to gamma radiation
G	0072719	biological_process	cellular response to cisplatin
G	0072757	biological_process	cellular response to camptothecin
G	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
G	0140664	molecular_function	ATP-dependent DNA damage sensor activity
G	1904631	biological_process	response to glucoside
G	1990426	biological_process	mitotic recombination-dependent replication fork processing
G	1990918	biological_process	double-strand break repair involved in meiotic recombination
G	2000001	biological_process	regulation of DNA damage checkpoint

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	20
Details	AAA AAA-protein family signature. IlVVgATNrpqeIDeAArrR

Chain	Residue	Details
B	ILE539-ARG558

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Human fidgetin-like protein 1.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CK2","evidences":[{"source":"PubMed","id":"22325354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26811421","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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