8R2G

Crystal structure of a BRCA2-DMC1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000150	molecular_function	DNA strand exchange activity
A	0003677	molecular_function	DNA binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0006259	biological_process	DNA metabolic process
A	0006281	biological_process	DNA repair
A	0007131	biological_process	reciprocal meiotic recombination
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0016887	molecular_function	ATP hydrolysis activity
A	0140664	molecular_function	ATP-dependent DNA damage sensor activity
B	0000150	molecular_function	DNA strand exchange activity
B	0003677	molecular_function	DNA binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0006259	biological_process	DNA metabolic process
B	0006281	biological_process	DNA repair
B	0007131	biological_process	reciprocal meiotic recombination
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0016887	molecular_function	ATP hydrolysis activity
B	0140664	molecular_function	ATP-dependent DNA damage sensor activity
C	0000150	molecular_function	DNA strand exchange activity
C	0003677	molecular_function	DNA binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0006259	biological_process	DNA metabolic process
C	0006281	biological_process	DNA repair
C	0007131	biological_process	reciprocal meiotic recombination
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0016887	molecular_function	ATP hydrolysis activity
C	0140664	molecular_function	ATP-dependent DNA damage sensor activity
D	0000150	molecular_function	DNA strand exchange activity
D	0003677	molecular_function	DNA binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0006259	biological_process	DNA metabolic process
D	0006281	biological_process	DNA repair
D	0007131	biological_process	reciprocal meiotic recombination
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0016887	molecular_function	ATP hydrolysis activity
D	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	0000150	molecular_function	DNA strand exchange activity
E	0003677	molecular_function	DNA binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0006259	biological_process	DNA metabolic process
E	0006281	biological_process	DNA repair
E	0007131	biological_process	reciprocal meiotic recombination
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0016887	molecular_function	ATP hydrolysis activity
E	0140664	molecular_function	ATP-dependent DNA damage sensor activity
F	0000150	molecular_function	DNA strand exchange activity
F	0003677	molecular_function	DNA binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0006259	biological_process	DNA metabolic process
F	0006281	biological_process	DNA repair
F	0007131	biological_process	reciprocal meiotic recombination
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0016887	molecular_function	ATP hydrolysis activity
F	0140664	molecular_function	ATP-dependent DNA damage sensor activity
G	0000150	molecular_function	DNA strand exchange activity
G	0003677	molecular_function	DNA binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0006259	biological_process	DNA metabolic process
G	0006281	biological_process	DNA repair
G	0007131	biological_process	reciprocal meiotic recombination
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0016887	molecular_function	ATP hydrolysis activity
G	0140664	molecular_function	ATP-dependent DNA damage sensor activity
H	0000150	molecular_function	DNA strand exchange activity
H	0003677	molecular_function	DNA binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0006259	biological_process	DNA metabolic process
H	0006281	biological_process	DNA repair
H	0007131	biological_process	reciprocal meiotic recombination
H	0008094	molecular_function	ATP-dependent activity, acting on DNA
H	0016887	molecular_function	ATP hydrolysis activity
H	0140664	molecular_function	ATP-dependent DNA damage sensor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	GLY126
B	GLY126
C	GLY126
D	GLY126
E	GLY126
F	GLY126
G	GLY126
H	GLY126

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site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269|PubMed:15125839

Chain	Residue	Details
A	ARG230
B	ARG311
C	ARG230
C	PHE233
C	ARG236
C	ARG242
C	ARG311
D	ARG230
D	PHE233
D	ARG236
D	ARG242
A	PHE233
D	ARG311
E	ARG230
E	PHE233
E	ARG236
E	ARG242
E	ARG311
F	ARG230
F	PHE233
F	ARG236
F	ARG242
A	ARG236
F	ARG311
G	ARG230
G	PHE233
G	ARG236
G	ARG242
G	ARG311
H	ARG230
H	PHE233
H	ARG236
H	ARG242
A	ARG242
H	ARG311
A	ARG311
B	ARG230
B	PHE233
B	ARG236
B	ARG242

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