8R1A

Model of the membrane-bound GBP1 oligomer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0001530	molecular_function	lipopolysaccharide binding
A	0002376	biological_process	immune system process
A	0003779	molecular_function	actin binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0004382	molecular_function	GDP phosphatase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0012506	cellular_component	vesicle membrane
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019899	molecular_function	enzyme binding
A	0019955	molecular_function	cytokine binding
A	0030507	molecular_function	spectrin binding
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0032703	biological_process	negative regulation of interleukin-2 production
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0050860	biological_process	negative regulation of T cell receptor signaling pathway
A	0051607	biological_process	defense response to virus
A	0051715	biological_process	cytolysis in another organism
A	0051879	molecular_function	Hsp90 protein binding
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	0071346	biological_process	cellular response to type II interferon
A	0071347	biological_process	cellular response to interleukin-1
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0072665	biological_process	protein localization to vacuole
A	0106139	cellular_component	symbiont cell surface
A	0140639	biological_process	positive regulation of pyroptotic inflammatory response
A	0160075	biological_process	non-canonical inflammasome complex assembly
A	1900025	biological_process	negative regulation of substrate adhesion-dependent cell spreading
A	1903076	biological_process	regulation of protein localization to plasma membrane
A	1903077	biological_process	negative regulation of protein localization to plasma membrane
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0001530	molecular_function	lipopolysaccharide binding
B	0002376	biological_process	immune system process
B	0003779	molecular_function	actin binding
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0004382	molecular_function	GDP phosphatase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0012506	cellular_component	vesicle membrane
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0019003	molecular_function	GDP binding
B	0019899	molecular_function	enzyme binding
B	0019955	molecular_function	cytokine binding
B	0030507	molecular_function	spectrin binding
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0032703	biological_process	negative regulation of interleukin-2 production
B	0042742	biological_process	defense response to bacterium
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042832	biological_process	defense response to protozoan
B	0045087	biological_process	innate immune response
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0050860	biological_process	negative regulation of T cell receptor signaling pathway
B	0051607	biological_process	defense response to virus
B	0051715	biological_process	cytolysis in another organism
B	0051879	molecular_function	Hsp90 protein binding
B	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
B	0071346	biological_process	cellular response to type II interferon
B	0071347	biological_process	cellular response to interleukin-1
B	0071356	biological_process	cellular response to tumor necrosis factor
B	0072665	biological_process	protein localization to vacuole
B	0106139	cellular_component	symbiont cell surface
B	0140639	biological_process	positive regulation of pyroptotic inflammatory response
B	0160075	biological_process	non-canonical inflammasome complex assembly
B	1900025	biological_process	negative regulation of substrate adhesion-dependent cell spreading
B	1903076	biological_process	regulation of protein localization to plasma membrane
B	1903077	biological_process	negative regulation of protein localization to plasma membrane
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0001530	molecular_function	lipopolysaccharide binding
C	0002376	biological_process	immune system process
C	0003779	molecular_function	actin binding
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0004382	molecular_function	GDP phosphatase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0012506	cellular_component	vesicle membrane
C	0015629	cellular_component	actin cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0019003	molecular_function	GDP binding
C	0019899	molecular_function	enzyme binding
C	0019955	molecular_function	cytokine binding
C	0030507	molecular_function	spectrin binding
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0032703	biological_process	negative regulation of interleukin-2 production
C	0042742	biological_process	defense response to bacterium
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042832	biological_process	defense response to protozoan
C	0045087	biological_process	innate immune response
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0050860	biological_process	negative regulation of T cell receptor signaling pathway
C	0051607	biological_process	defense response to virus
C	0051715	biological_process	cytolysis in another organism
C	0051879	molecular_function	Hsp90 protein binding
C	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
C	0071346	biological_process	cellular response to type II interferon
C	0071347	biological_process	cellular response to interleukin-1
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0072665	biological_process	protein localization to vacuole
C	0106139	cellular_component	symbiont cell surface
C	0140639	biological_process	positive regulation of pyroptotic inflammatory response
C	0160075	biological_process	non-canonical inflammasome complex assembly
C	1900025	biological_process	negative regulation of substrate adhesion-dependent cell spreading
C	1903076	biological_process	regulation of protein localization to plasma membrane
C	1903077	biological_process	negative regulation of protein localization to plasma membrane
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0001530	molecular_function	lipopolysaccharide binding
D	0002376	biological_process	immune system process
D	0003779	molecular_function	actin binding
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0004382	molecular_function	GDP phosphatase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0012506	cellular_component	vesicle membrane
D	0015629	cellular_component	actin cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0019003	molecular_function	GDP binding
D	0019899	molecular_function	enzyme binding
D	0019955	molecular_function	cytokine binding
D	0030507	molecular_function	spectrin binding
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0032703	biological_process	negative regulation of interleukin-2 production
D	0042742	biological_process	defense response to bacterium
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042832	biological_process	defense response to protozoan
D	0045087	biological_process	innate immune response
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0050860	biological_process	negative regulation of T cell receptor signaling pathway
D	0051607	biological_process	defense response to virus
D	0051715	biological_process	cytolysis in another organism
D	0051879	molecular_function	Hsp90 protein binding
D	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
D	0071346	biological_process	cellular response to type II interferon
D	0071347	biological_process	cellular response to interleukin-1
D	0071356	biological_process	cellular response to tumor necrosis factor
D	0072665	biological_process	protein localization to vacuole
D	0106139	cellular_component	symbiont cell surface
D	0140639	biological_process	positive regulation of pyroptotic inflammatory response
D	0160075	biological_process	non-canonical inflammasome complex assembly
D	1900025	biological_process	negative regulation of substrate adhesion-dependent cell spreading
D	1903076	biological_process	regulation of protein localization to plasma membrane
D	1903077	biological_process	negative regulation of protein localization to plasma membrane
E	0000139	cellular_component	Golgi membrane
E	0000166	molecular_function	nucleotide binding
E	0001530	molecular_function	lipopolysaccharide binding
E	0002376	biological_process	immune system process
E	0003779	molecular_function	actin binding
E	0003924	molecular_function	GTPase activity
E	0003925	molecular_function	G protein activity
E	0004382	molecular_function	GDP phosphatase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0012506	cellular_component	vesicle membrane
E	0015629	cellular_component	actin cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0019003	molecular_function	GDP binding
E	0019899	molecular_function	enzyme binding
E	0019955	molecular_function	cytokine binding
E	0030507	molecular_function	spectrin binding
E	0030659	cellular_component	cytoplasmic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0032703	biological_process	negative regulation of interleukin-2 production
E	0042742	biological_process	defense response to bacterium
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042832	biological_process	defense response to protozoan
E	0045087	biological_process	innate immune response
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0050860	biological_process	negative regulation of T cell receptor signaling pathway
E	0051607	biological_process	defense response to virus
E	0051715	biological_process	cytolysis in another organism
E	0051879	molecular_function	Hsp90 protein binding
E	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
E	0071346	biological_process	cellular response to type II interferon
E	0071347	biological_process	cellular response to interleukin-1
E	0071356	biological_process	cellular response to tumor necrosis factor
E	0072665	biological_process	protein localization to vacuole
E	0106139	cellular_component	symbiont cell surface
E	0140639	biological_process	positive regulation of pyroptotic inflammatory response
E	0160075	biological_process	non-canonical inflammasome complex assembly
E	1900025	biological_process	negative regulation of substrate adhesion-dependent cell spreading
E	1903076	biological_process	regulation of protein localization to plasma membrane
E	1903077	biological_process	negative regulation of protein localization to plasma membrane
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0001530	molecular_function	lipopolysaccharide binding
F	0002376	biological_process	immune system process
F	0003779	molecular_function	actin binding
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0004382	molecular_function	GDP phosphatase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0012506	cellular_component	vesicle membrane
F	0015629	cellular_component	actin cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0019003	molecular_function	GDP binding
F	0019899	molecular_function	enzyme binding
F	0019955	molecular_function	cytokine binding
F	0030507	molecular_function	spectrin binding
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0032703	biological_process	negative regulation of interleukin-2 production
F	0042742	biological_process	defense response to bacterium
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042832	biological_process	defense response to protozoan
F	0045087	biological_process	innate immune response
F	0050848	biological_process	regulation of calcium-mediated signaling
F	0050860	biological_process	negative regulation of T cell receptor signaling pathway
F	0051607	biological_process	defense response to virus
F	0051715	biological_process	cytolysis in another organism
F	0051879	molecular_function	Hsp90 protein binding
F	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
F	0071346	biological_process	cellular response to type II interferon
F	0071347	biological_process	cellular response to interleukin-1
F	0071356	biological_process	cellular response to tumor necrosis factor
F	0072665	biological_process	protein localization to vacuole
F	0106139	cellular_component	symbiont cell surface
F	0140639	biological_process	positive regulation of pyroptotic inflammatory response
F	0160075	biological_process	non-canonical inflammasome complex assembly
F	1900025	biological_process	negative regulation of substrate adhesion-dependent cell spreading
F	1903076	biological_process	regulation of protein localization to plasma membrane
F	1903077	biological_process	negative regulation of protein localization to plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16511497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39394410","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CQB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"PubMed","id":"8830800","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Lipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31268602","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32510692","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8830800","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	54
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---