8QYZ

Crystal structure of hiNES2 in complex with Xpo1 and RanGTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006913	biological_process	nucleocytoplasmic transport
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0006913	biological_process	nucleocytoplasmic transport
C	0000055	biological_process	ribosomal large subunit export from nucleus
C	0000056	biological_process	ribosomal small subunit export from nucleus
C	0000776	cellular_component	kinetochore
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005816	cellular_component	spindle pole body
C	0006406	biological_process	mRNA export from nucleus
C	0006409	biological_process	tRNA export from nucleus
C	0006611	biological_process	protein export from nucleus
C	0006886	biological_process	intracellular protein transport
C	0015031	biological_process	protein transport
C	0017070	molecular_function	U6 snRNA binding
C	0030619	molecular_function	U1 snRNA binding
C	0030620	molecular_function	U2 snRNA binding
C	0030621	molecular_function	U4 snRNA binding
C	0030623	molecular_function	U5 snRNA binding
C	0031267	molecular_function	small GTPase binding
C	0034501	biological_process	protein localization to kinetochore
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051168	biological_process	nuclear export
C	0051170	biological_process	import into nucleus
C	0061608	molecular_function	nuclear import signal receptor activity
C	0071528	biological_process	tRNA re-export from nucleus
D	0000055	biological_process	ribosomal large subunit export from nucleus
D	0000056	biological_process	ribosomal small subunit export from nucleus
D	0000776	cellular_component	kinetochore
D	0005049	molecular_function	nuclear export signal receptor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005816	cellular_component	spindle pole body
D	0006406	biological_process	mRNA export from nucleus
D	0006409	biological_process	tRNA export from nucleus
D	0006611	biological_process	protein export from nucleus
D	0006886	biological_process	intracellular protein transport
D	0015031	biological_process	protein transport
D	0017070	molecular_function	U6 snRNA binding
D	0030619	molecular_function	U1 snRNA binding
D	0030620	molecular_function	U2 snRNA binding
D	0030621	molecular_function	U4 snRNA binding
D	0030623	molecular_function	U5 snRNA binding
D	0031267	molecular_function	small GTPase binding
D	0034501	biological_process	protein localization to kinetochore
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051168	biological_process	nuclear export
D	0051170	biological_process	import into nucleus
D	0061608	molecular_function	nuclear import signal receptor activity
D	0071528	biological_process	tRNA re-export from nucleus
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
E	0006913	biological_process	nucleocytoplasmic transport
F	0000055	biological_process	ribosomal large subunit export from nucleus
F	0000056	biological_process	ribosomal small subunit export from nucleus
F	0000776	cellular_component	kinetochore
F	0005049	molecular_function	nuclear export signal receptor activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005816	cellular_component	spindle pole body
F	0006406	biological_process	mRNA export from nucleus
F	0006409	biological_process	tRNA export from nucleus
F	0006611	biological_process	protein export from nucleus
F	0006886	biological_process	intracellular protein transport
F	0015031	biological_process	protein transport
F	0017070	molecular_function	U6 snRNA binding
F	0030619	molecular_function	U1 snRNA binding
F	0030620	molecular_function	U2 snRNA binding
F	0030621	molecular_function	U4 snRNA binding
F	0030623	molecular_function	U5 snRNA binding
F	0031267	molecular_function	small GTPase binding
F	0034501	biological_process	protein localization to kinetochore
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051168	biological_process	nuclear export
F	0051170	biological_process	import into nucleus
F	0061608	molecular_function	nuclear import signal receptor activity
F	0071528	biological_process	tRNA re-export from nucleus
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
G	0006913	biological_process	nucleocytoplasmic transport
H	0000055	biological_process	ribosomal large subunit export from nucleus
H	0000056	biological_process	ribosomal small subunit export from nucleus
H	0000776	cellular_component	kinetochore
H	0005049	molecular_function	nuclear export signal receptor activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005816	cellular_component	spindle pole body
H	0006406	biological_process	mRNA export from nucleus
H	0006409	biological_process	tRNA export from nucleus
H	0006611	biological_process	protein export from nucleus
H	0006886	biological_process	intracellular protein transport
H	0015031	biological_process	protein transport
H	0017070	molecular_function	U6 snRNA binding
H	0030619	molecular_function	U1 snRNA binding
H	0030620	molecular_function	U2 snRNA binding
H	0030621	molecular_function	U4 snRNA binding
H	0030623	molecular_function	U5 snRNA binding
H	0031267	molecular_function	small GTPase binding
H	0034501	biological_process	protein localization to kinetochore
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0051168	biological_process	nuclear export
H	0051170	biological_process	import into nucleus
H	0061608	molecular_function	nuclear import signal receptor activity
H	0071528	biological_process	tRNA re-export from nucleus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62825","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	264
Details	Domain: {"description":"Importin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00115","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---